The role of acetate in alcohol-induced alterations of uterine glucose metabolism in the mouse during pregnancy

Simm, Brett; Murdoch, R. N.

doi:10.1016/0024-3205(90)90478-a

Life Sciences

1990

DOI: 10.1016/0024-3205(90)90478-a

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The role of acetate in alcohol-induced alterations of uterine glucose metabolism in the mouse during pregnancy

Brett Simm

R. N. Murdoch

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1992

2006

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Cited by 5 publications

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“…The cortical atrophy or alcoholic cerebellar atrophy are often reported in chronic alcoholic patients [6]. The large consumption of ethanol in the pregnancy causes fetal alcohol syndrome (FAS), which is characterized by growth retardation, facial anomalies such as short palpebral fissures, flat mid face, maxillary hypoplasia, and mental retardation of the newborns [2,7,10,21].…”

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confidence: 99%

Detection of in vivo DNA Damage Induced by Ethanol in Multiple Organs of Pregnant Mice Using the Alkaline Single Cell Gel Electrophoresis (Comet) Assay

Kido

Sato

Tsuda

2006

The Journal of Veterinary Medical Science

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ABSTRACT. Ethanol is principal ingredient of alcohol beverage, but considered as human carcinogen, and has neurotoxicity. Alcohol consumption during pregnancy often causes fetal alcohol syndrome. The DNA damage is one of the important factors in carcinogenicity or teratogenicity. To detect the DNA damage induced by ethanol, we used an in vivo alkaline single cell gel electrophoresis (Comet) assay in pregnant mice organs and embryos. Pregnant ICR mice on Day 7 of gestation were treated with 2, 4 or 8 g/kg ethanol, and maternal organs/tissues and embryos were subjected to the Comet assay at 4, 8, 12 and 24 hr after ethanol treatment. Four and 8 g/kg ethanol induced DNA damage in brain, lung and embryos at 4 or 8 hr after the treatment. Two g/kg ethanol did not cause any DNA damage, and 8 g/kg ethanol only increased the duration of DNA damage without distinct increase in the degree of the damage. No significant DNA damage was observed in the liver. To detect the effect of acetaldehyde, disulfiram, acetaldehyde dehydrogenase inhibitor, was administered before 4 g/kg ethanol treatment. No significant increase of DNA damage was observed in the disulfiram pre-treated group. These data indicate that ethanol induces DNA damage, which might be related to ethanol toxicity. Since pre-treatment of disulfiram did not increase DNA damage, DNA damage observed in this study might not be the effect of acetaldehyde. KEY WORDS: Comet assay, DNA damage, ethanol, pregnant mouse.

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confidence: 99%

Detection of in vivo DNA Damage Induced by Ethanol in Multiple Organs of Pregnant Mice Using the Alkaline Single Cell Gel Electrophoresis (Comet) Assay

Kido

Sato

Tsuda

2006

The Journal of Veterinary Medical Science

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Teratogenic effects of ethanol in the Quackenbush Special mouse

Amini

Dunkley

Murdoch

1996

Drug and Alcohol Dependence

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Impaired glucose homeostasis during postimplantation pregnancy in the mouse following acute exposure to ethanol, with particular reference to the uterus and embryo

Murdoch

Simm

1992

Biochemical Medicine and Metabolic Biology

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The role of acetate in alcohol-induced alterations of uterine glucose metabolism in the mouse during pregnancy

Cited by 5 publications

References 22 publications

Detection of in vivo DNA Damage Induced by Ethanol in Multiple Organs of Pregnant Mice Using the Alkaline Single Cell Gel Electrophoresis (Comet) Assay

Detection of in vivo DNA Damage Induced by Ethanol in Multiple Organs of Pregnant Mice Using the Alkaline Single Cell Gel Electrophoresis (Comet) Assay

Teratogenic effects of ethanol in the Quackenbush Special mouse

Impaired glucose homeostasis during postimplantation pregnancy in the mouse following acute exposure to ethanol, with particular reference to the uterus and embryo

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