The role of Actinomyces spp. and related organisms in cervicofacial infections: Pathomechanism, diagnosis and therapeutic aspects

Kövér, Zsanett; Johansen Nordskag, Vidar; Bán, Ágnes; Gajdács, Márió; Urbán, Edit

doi:10.1016/j.anaerobe.2023.102767

Cited by 5 publications

(1 citation statement)

References 114 publications

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“…Interestingly, our study revealed that the genus Actinomyces , as a representative genus of the family Actinomycetaceae , is a shared risk factor for left-sided colitis and ulcerative proctosigmoiditis. This facultative anaerobic bacterium, with pathogenic fimbriae, can elevate local mucosal levels of IL-6 and IL-8, promoting mucosal inflammation and neutrophil-mediated tissue damage ( Kövér et al., 2023 ). Multiple studies on patients with concurrent inflammatory bowel disease (IBD) and primary sclerosing cholangitis (PSC) have confirmed a significant increase in the genus Blautia ( Quraishi et al., 2017 )and a notable decrease in the genus Prevotella in the IBD-PSC population ( Quraishi et al., 2017 ; Quraishi et al., 2020 ).…”

Section: Discussionmentioning

confidence: 99%

Exploring the intestinal ecosystem: from gut microbiota to associations with subtypes of inflammatory bowel disease

Li,

Yu,

Zhao

et al. 2024

Front. Cell. Infect. Microbiol.

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ObjectiveSignificant differences have been discovered between subtypes of Crohn’s disease (CD) and ulcerative colitis (UC). The role of gut microbiota in promoting the onset of UC and CD is established, but conclusions regarding subtype-specific analyses remain limited.MethodsThis study aims to explore the influence of gut microbiota on subtypes of UC and CD, offering novel insights into the pathogenesis and treatment of UC and CD.Two-sample Mendelian randomization (MR) analysis was employed to examine the causal relationship between subtypes of UC and CD and gut microbiota composition. Gut microbiota data were sourced from the International Consortium MiBioGen, while UC and CD data were obtained from FINNGEN. Eligible single nucleotide polymorphisms (SNPs) were selected as instrumental variables. Multiple analytical approaches such as inverse variance-weighted (IVW), MR-Egger regression, weighted median, weighted mode, and MR-RAPS were utilized. Sensitivity analyses including MR-Egger intercept test, Cochran’s Q test, and leave-one-out analysis were conducted for quality control. Subsequently, we employed multivariable IVW, MR-Egger, weighted median, and LASSO regression methods to identify independently significant genera or families and conducted sensitivity analyses.ResultsWe have determined that Hungatella, Acidaminococcaceae, and 15 other microbial taxa act as protective factors for various CD and UC subtypes, while Terrisporobacter, Anaerostipes, and 23 other microbial taxa are associated with increased risk for different CD and UC subtypes. Furthermore, through multivariable MR analysis, we have identified significant genera or families with independent effects.ConclusionOur study confirms a causal relationship between dysbiosis of gut microbiota and the occurrence of CD and UC subtypes. Furthermore, it validates etiological distinctions among different subtypes of CD and UC. A novel approach to adjunctive therapy involving distinct UC or CD subtypes may involve the use of probiotics and represents a potential avenue for future treatments.

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Section: Discussionmentioning

confidence: 99%

Exploring the intestinal ecosystem: from gut microbiota to associations with subtypes of inflammatory bowel disease

Li,

Yu,

Zhao

et al. 2024

Front. Cell. Infect. Microbiol.

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Antimicrobial and Antiproliferative Effects of Zingiberaceae Oils: A Natural Solution for Oral Health

Amil,

Rahman,

Yap

et al. 2024

Chemistry & Biodiversity

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Essential oils have been recognised for their potential benefits in oral care. The aim of this study was to evaluate the antibacterial and antiproliferative activity of essential oils derived from four Zingiberaceae species. A combination of GC/MS and GC‐FID was employed to analyse these essential oils. The results showed that β‐myrcene (79.77%) followed by ethyl‐cinnamate (40.14%), β‐curcumene (34.90%), and alloaromadendrene (25.15%) as the primary constituents of Curcuma mangga, Curcuma xanthorrhiza, Kaempferia galanga and Curcuma aeruginosa, respectively. The Zingiberaceae oils were tested for their antibacterial activity against oral bacteria using the disc diffusion test. Curcuma xanthorrhiza oil showed the largest inhibition zones against Streptococcus mitis (19.50 ± 2.22 mm) and Streptococcus sanguinis (15.04 ± 3.05 mm). Similarly, Curcuma mangga oil exhibited significant antibacterial activity against Streptococcus mutans (12.55 ± 0.45 mm) and mixed oral bacteria (15.03 ± 3.82 mm). Furthermore, the MTT viability assay revealed moderate inhibitory activity of these essential oils against H103 and ORL‐204 oral cancer cells. The study findings demonstrate that Curcuma xanthorrhiza and Curcuma mangga essential oils have potent antibacterial properties, suggesting their potential use as natural alternatives to synthetic antibacterial agents in oral care products. However, further investigations are necessary to fully explore their therapeutic applications.

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Exploring Nocardia’s ecological spectrum and novel therapeutic frontiers through whole-genome sequencing: unraveling drug resistance and virulence factors

Nathar,

Rajmichael,

Jeyaraj Pandian

et al. 2024

Arch Microbiol

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The role of Actinomyces spp. and related organisms in cervicofacial infections: Pathomechanism, diagnosis and therapeutic aspects

Cited by 5 publications

References 114 publications

Exploring the intestinal ecosystem: from gut microbiota to associations with subtypes of inflammatory bowel disease

Exploring the intestinal ecosystem: from gut microbiota to associations with subtypes of inflammatory bowel disease

Antimicrobial and Antiproliferative Effects of Zingiberaceae Oils: A Natural Solution for Oral Health

Exploring Nocardia’s ecological spectrum and novel therapeutic frontiers through whole-genome sequencing: unraveling drug resistance and virulence factors

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