The role of activins and follistatins in skin and hair follicle development and function

McDowall, M.; Edwards, Natalie; Jahoda, Colin A.B.; Hynd, P. I.

doi:10.1016/j.cytogfr.2008.08.005

Cited by 46 publications

(57 citation statements)

References 74 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…WFIKKN2 can bind bone morphogenetic protein 2 (BMP2) and bone morphogenetic protein 4 (BMP4) with relatively high affinity (Szlama et al, 2010), and the genes for these two proteins are expressed in hair shaft precursor cells (Kulessa et al, 2000), while ectopic expression of BMP2 or BMP4 suppresses the formation of feather buds in chick embryos (Jung et al, 1998;Noramly and Morgan, 1998). Additionally, because WFIKKN2 possesses a follistatin-domain, it may have an overlapping function with follistatin, which has been shown to be an important regulator of cell proliferation, differentiation and apoptosis in hair follicle initiation, hair cycling, normal skin homeostasis and wound healing (McDowall et al, 2008). This speculation would need to be investigated by looking for associations between WFIKKN2 variation and variation in wool traits.…”

Section: Discussionmentioning

confidence: 99%

Variation in the ovine WFIKKN2 gene

Wang

Zhou

Qian

et al. 2014

Gene

View full text Add to dashboard Cite

a b s t r a c t a r t i c l e i n f oWFIKKN2 may play a role in the regulation of muscle growth and development through its interaction with growth and differentiation factor 8 (GDF8) and growth and differentiation factor 11 (GDF11), but to date research into the function of the protein has been focused on mice, even though the WFIKKN2 gene (WFIKKN2) was first identified in humans in 2001. In this study two regions (intron 1 and the 3′ UTR) of ovine WFIKKN2 were investigated, using Polymerase Chain Reaction-Single Stranded Conformational Polymorphism (PCR-SSCP). Two different PCR-SSCP patterns, representing two unique DNA sequences (designated a and b) were detected in a 399-bp amplicon derived from the 3′ UTR, with sequence analysis revealing one single nucleotide polymorphism (SNP). In a 421-bp amplicon from intron 1, five different PCR-SSCP patterns (designated A-E) were observed and twelve SNPs were detected. Either one or two different sequences were detected in individual sheep and all the sequences identified shared homology with the WFIKKN2 sequences from cattle and other animal species, suggesting that these sequences represent variants of the ovine WFIKKN2 gene. In intron 1 of 487 sheep from eight breeds, variants B and C were the most common, followed by A, D and E. These results indicate that ovine WFIKKN2 is polymorphic and suggest that further analysis is required to see if variation in the gene is associated with variation in growth and muscle traits in sheep.

show abstract

Section: Discussionmentioning

confidence: 99%

Variation in the ovine WFIKKN2 gene

Wang

Zhou

Qian

et al. 2014

Gene

View full text Add to dashboard Cite

show abstract

“…In transgenic mice lacking various components of the activin signaling pathways, various ectodermal pathologies have been observed, including altered pelage hair follicle initiation [McDowall et al, 2008]. At the mRNA level, activin-βA has been detected in dermal papilla (DP) cells of the hair follicle mesenchyme.…”

Section: Activin B Promotes Initiation and Development Of Hair Follicmentioning

confidence: 99%

Activin B Promotes Initiation and Development of Hair Follicles in Mice

Jia

Zhang²,

Kong³

et al. 2013

Cells Tissues Organs

View full text Add to dashboard Cite

Activin B has been reported to promote the regeneration of hair follicles during wound healing. However, its role in the development and life cycle of hair follicles has not been elucidated.In our study, the effect of activin B on mouse hair follicles of cultured and neonatal mouse skin was investigated. In these models, PBS or activin B (5, 10 or 50 ng/ml) was applied, and hair follicle development was monitored. Hair follicle initiation and development was examined using hematoxylin and eosin staining, alkaline phosphatase activity staining, Oil Red O+ staining, and the detection of TdT-mediated dUTP-biotin nick end-labeling cell apoptosis. Activin B was found to efficiently induce the initiation of hair follicles in the skin of both cultured and neonatal mice and to promote the development of hair follicles in neonatal mouse skin. Moreover, activin-B-treated hair follicles were observed to enter the anagen stage from the telogen stage and to remain in the anagen stage. These results demonstrate that activin B promotes the initiation and development of hair follicles in mice.

show abstract

“…Activins are dimers, comprising two β-subunits linked by a single, covalent disulphide bond; five different β-subunits (A–E) have been identified. Activins A (βAβA) and B (βBβB) are the most common types expressed in various tissues (McDowall et al ., 2008). …”

Section: Introductionmentioning

confidence: 99%

Conditional Activin Receptor Type 1B (Acvr1b) Knockout Mice Reveal Hair Loss Abnormality

Qiu

Tang

et al. 2011

Journal of Investigative Dermatology

View full text Add to dashboard Cite

The in vivo functions of the activin A receptor type 1b (Acvr1b) have been difficult to study because Acvr1b−/− mice die during embryogenesis. To investigate the roles of Acvr1b in the epithelial tissues, we created mice with a conditional disruption of Acvr1b (Acvr1bflox/flox) and crossed them with K14-Cre mice. Acvr1bflox/flox; K14-Cre mice displayed various degrees of hairlessness at postnatal day 5, and the phenotype is exacerbated by age. Histological analyses showed that those hair follicles that developed during morphogenesis were later disrupted by delays in hair cycle reentry. Failure in cycling of the hair follicles and regrowth of the hair shaft and the inner root sheath resulted in subsequent severe hair loss. Apart from previous reports of other members of the transforming growth factor-β/activin/bone morphogenic protein pathways, we demonstrate a specialized role for Acvr1b in hair cycling in addition to hair follicle development. Acvr1bflox/flox; K14-Cre mice also had a thicker epidermis than did wild-type mice, which resulted from persistent proliferation of skin epithelial cells; however, no tumor formation was observed by 18 months of age. Our analysis of this Acvr1b knockout mouse line provides direct genetic evidence that Acvr1b signaling is required for both hair follicle development and cycling.

show abstract

The role of activins and follistatins in skin and hair follicle development and function

Cited by 46 publications

References 74 publications

Variation in the ovine WFIKKN2 gene

Variation in the ovine WFIKKN2 gene

Activin B Promotes Initiation and Development of Hair Follicles in Mice

Conditional Activin Receptor Type 1B (Acvr1b) Knockout Mice Reveal Hair Loss Abnormality

Contact Info

Product

Resources

About