The Role of Acupuncture Improving Cognitive Deficits due to Alzheimer’s Disease or Vascular Diseases through Regulating Neuroplasticity

Ji, Shou‐Ping; Duan, Jia-Yu; Hou, Xiyong; Zhou, Li; Qin, Wei-Lan; Niu, Huanmin; Luo, Shuyun; Zhang, Yunling; Chan, Piu; Jin, Xin

doi:10.1155/2021/8868447

Cited by 13 publications

(8 citation statements)

References 124 publications

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“…Acupuncture may also improve LTP deficiencies and boost cerebral blood flow to lessen dementia symptoms, according to animal studies ( 57 ). A previous systematic review found that MA improved MoCA and MMSE scores in elderly patients with MCI, indicating that MA may have some therapeutic benefits for senior patients with MCI ( 58 ). Additionally, a clinical investigation using MA to treat MCI demonstrated that manual acupuncture was beneficial in enhancing memory and cognitive function in MCI patients ( 59 ).…”

Section: Discussionmentioning

confidence: 99%

Comparative efficacy of acupuncture-related techniques for mild cognitive impairment: A Bayesian network analysis

Lai

et al. 2022

Front. Neurol.

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BackgroundA comparison and ranking of the clinical effects of various acupuncture and acupuncture-related therapies on patients with mild cognitive impairment.MethodsUsing network meta-analysis, we assessed the direct and indirect evidence from relevant research. Seven databases [PubMed, Web of Science, Cochrane Library, EMBASE, China National Knowledge Infrastructure (CNKI), VIP Database, and Wanfang database] were examined to find randomized controlled trials of acupuncture-related therapies for individuals with mild cognitive impairment. Two researchers independently reviewed the literature, retrieved the data, and evaluated the risk of bias in the included studies. The data were analyzed using Stata15.0 and R3.6.1 software.ResultsA total of 27 randomized controlled trials involving 2,210 patients were included. Bayesian NMA showed that manual acupuncture combined with conventional therapy, moxibustion combined with conventional therapy, manual acupuncture, and electroacupuncture were most effective in improving the MMSE score. The most effective interventions related to the MoCA score were moxibustion combined with conventional therapy, followed by manual acupuncture combined with conventional therapy, acupressure combined with conventional therapy, and manual acupuncture combined with moxibustion. Manual acupuncture combined with moxibustion was dominant in the cluster ranking. The results of the node splitting method revealed that direct and indirect evidence were consistent (P > 0.05). In addition, publication bias was detected.ConclusionThis research will add to the body of knowledge about the safety and efficacy of acupuncture-related therapies in the treatment of mild cognitive impairment. The results of this study will also assist in the choice of clinical guidelines that optimize acupuncture treatment for patients with mild cognitive impairment.

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Section: Discussionmentioning

confidence: 99%

Comparative efficacy of acupuncture-related techniques for mild cognitive impairment: A Bayesian network analysis

Lai

et al. 2022

Front. Neurol.

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“…Eine taiwanesische Studie konnte in einem größeren Kollektiv in einer Propensity-Score-matched-Kohortenstudie die Übertragung der vorhergehenden Überlegungen auf Real-World-Daten bewerkstelligen und wies ein erniedrigtes Demenzrisiko bei an einer depressiven Störung Erkrankten nach, die sich aufgrund der affektiven Erkrankung einer Akupunkturbehandlung unterzogen [20]. Neben diesem Einfluss konnten in Mausmodellen ein erhöhter zerebraler Blutfluss, eine Veränderung auf Transmitterebene und eine differente Rekrutierung verschiedener Gehirnnetzwerke gefunden werden [21][22][23].…”

Section: Tcmunclassified

Alter und Altern aus Sicht der Schul- und der Chinesischen Medizin

Agarwal¹,

Spyra²

2023

AkupunkturPraxis

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Die Traditionelle Chinesische Medizin (TCM) bietet uns Chancen, den Entwicklungsgang zu modulieren zu einem leichteren und erfüllten Altern. Dies darf aber nicht mit einem „Anti-Aging-Programm“ verwechselt werden. Es geht um „healthy aging“ im Sinne des Erhalts einer guten Lebensqualität mit Kontrolle über die Aktivitäten des täglichen Lebens als „best agers“ – alt an Jahren, aber gesund in Körper, Geist und Seele. Der Ansatz geht dabei davon aus, dass ein gutes energetisches Gleichgewicht bei der Geburt eines Menschen vorhanden ist, das zeitlebens aufrechterhalten werden sollte. Blockaden des Energieflusses führen zu Erkrankungen, da dann das Abwehr-Qi (Wei-Qi) durch pathogene Einflüsse geschwächt wird und die Versorgung aller Organe behindert. Dies gilt es zu vermeiden.

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“…However, a limited number of targeted drugs effectively improved cognitive function in CSVDCI patients (Pantoni, 2010), with minimal efficacy for dementia (Bath and Wardlaw, 2015). Interestingly, acupuncture has been widely used in China as a complementary alternative treatment for dementia, and also been accepted for VCI treatment in Western medicine (Ji et al, 2021). The main advantage of acupuncture is the lower incidence of adverse effects that characterize pharmaceutical approaches (NIH Consensus Conference, 1998;Kim et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

Increased low frequency fluctuation in the brain after acupuncture treatment in CSVDCI patients: A randomized control trial study

et al. 2023

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BackgroundCerebral small vessel disease (CSVD) is one of two cognition-impairing diseases. Acupuncture (Acu) is a flexible treatment with few adverse effects and is thus widely used to treat neurological problems.MethodsWe recruited a total of 60 patients and assigned them to two groups (n = 30 each group). During the study, some participants were excluded by quality control, and a total of 44 subjects (25 Acu and 19 controls) were completed to investigate the therapeutic efficacy of acupuncture on CSVD cognitive impairment (CSVDCI). The following demographic and clinical variables were compared between the two groups: gender, age, education, smoking, alcohol, Montreal cognitive assessment (MoCA), symbol digit modalities test (SDMT), verbal fluency test (VFT), digit span task (DST), Boston naming test (BNT) scores, and amplitude of low-frequency fluctuation (ALFF) under the typical band (0.01–0.08 Hz). Mixed effect analysis was utilized to test for differences between the two groups before and after the treatment.ResultsFollowing acupuncture treatment, the Acu group scored higher on MoCA, SDMT, VFT, DST, and BNT compared to controls (P < 0.05). The brain regions showing substantially greater ALFF values in the Acu group were the right inferior temporal gyrus, left middle occipital gyrus, left superior occipital gyrus, left insula, bilateral postcentral gyrus, right superior parietal gyrus, right cerebellum, right precuneus, and right precentral gyrus (P < 0.005, no correction). The ALFF values in the right inferior temporal gyrus (P = 0.027), left middle occipital gyrus (P = 0.005), left superior occipital gyrus (P = 0.011), and right superior parietal gyrus (P = 0.043) were positively associated with MoCA.ConclusionWe found that acupuncture modulates the functional activity of temporal, occipital, and parietal regions of the brain in CSVDCI patients.

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The Role of Acupuncture Improving Cognitive Deficits due to Alzheimer’s Disease or Vascular Diseases through Regulating Neuroplasticity

Cited by 13 publications

References 124 publications

Comparative efficacy of acupuncture-related techniques for mild cognitive impairment: A Bayesian network analysis

Comparative efficacy of acupuncture-related techniques for mild cognitive impairment: A Bayesian network analysis

Alter und Altern aus Sicht der Schul- und der Chinesischen Medizin

Increased low frequency fluctuation in the brain after acupuncture treatment in CSVDCI patients: A randomized control trial study

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