The role of adipokines in gestational diabetes mellitus

Al‐Badri, Marwa; Zantout, Mira S.; Azar, Sami T.

doi:10.1177/2042018815577039

Cited by 60 publications

(38 citation statements)

References 23 publications

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“…Like other forms of hyperglycemia, GDM is characterized by pancreatic β-cell function that is insufficient to meet the body's insulin needs (Al-Badri et al, 2015).…”

Section: Gestational Diabetes Mellitusmentioning

confidence: 99%

The role of visfatin (PBEF/Nampt) in pregnancy complications

Pavlová

Novák

Bienertová-Vašků

2015

Journal of Reproductive Immunology

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“…Like other forms of hyperglycemia, GDM is characterized by pancreatic β-cell function that is insufficient to meet the body's insulin needs (Al-Badri et al, 2015).…”

Section: Gestational Diabetes Mellitusmentioning

confidence: 99%

The role of visfatin (PBEF/Nampt) in pregnancy complications

Pavlová

Novák

Bienertová-Vašků

2015

Journal of Reproductive Immunology

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“…[1011] β-cell reserve is insufficient to compensate for the increased IR that occurs during pregnancy. Changes in β-cell mass adapt to physiological needs and increased functional demands.…”

Section: Discussionmentioning

confidence: 99%

Serum adiponectin levels in gestational diabetes mellitus

Bhograj

Suryanarayana

Nayak

et al. 2016

Indian J Endocr Metab

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Introduction:Gestational diabetes mellitus (GDM) is defined as any degree of glucose intolerance with onset or first recognition during pregnancy.[1] Pregnancy is a unique situation in which there is a physiological temporary increase in insulin resistance (IR). The mechanisms responsible for the gestational-induced IR are not completely understood. The current study was undertaken to compare adiponectin levels during 24–28 weeks period of gestation in drug-naive newly diagnosed GDM women with a cohort of normoglycemic pregnant women.Subjects and Methods:A total of 47 pregnant women in the age group of 18–40 years were included in this cross-sectional study, of which 13 were GDM cases and 34 were normoglycemic controls. Serum adiponectin level was analyzed by enzyme-linked immunosorbent assay.Results:The mean adiponectin level was 16.92 ng/ml (standard deviation [SD] = 2.78) and 19.38 ng/ml (SD = 2.71) in case and control groups, respectively, and the difference was found to be statistically significant (P = 0.008).Conclusion:Our study demonstrated decreased serum adiponectin levels in women with GDM when compared with age- and body mass index-matched euglycemic pregnant women.

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“…Adiponectin is thought to play a role in the regulation of glucose and lipid metabolism, and exhibits insulin-sensitizing and anti-inflammatory properties. 18, 19 Hormones play a major role in the development of several common cancers, probably due to their effect on cell division, with circulating estrogens linked to higher risk of endometrial, and breast cancers among other cancers. 20 Also, higher circulating levels of C-peptide, a marker of insulin secretion, have been positively associated with higher risk of several cancers.…”

Section: Introductionmentioning

confidence: 99%

Associations between adherence to the World Cancer Research Fund/American Institute for Cancer Research cancer prevention recommendations and biomarkers of inflammation, hormonal, and insulin response

Tabung

Fung

Chavarro

et al. 2016

Intl Journal of Cancer

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Adherence to the 2007 WCRF/AICR cancer prevention recommendations has been associated with lower cancer risk but the underlying biological mechanisms have not been elucidated. We utilized dietary and lifestyle data from 11,342 women in the Nurses’ Health Study and 8,136 men in the Health Professionals Follow-up Study, to investigate associations between adherence scores and markers of inflammation, hormonal and insulin response. Two scores ranging from 0 to 3 were constructed to assess adherence to the energy balance-related recommendations (weight management, physical activity, energy density); and the plant, animal foods and alcohol intake recommendations; with higher scores indicating greater adherence. The following biomarkers were assessed in plasma samples donated by chronic disease-free women (1990) and men (1994): C-reactive protein (CRP), interleukin-6 (IL6), tumor necrosis factor alpha receptor 2 (TNFαR2) and adiponectin for inflammation; estrone and estradiol for hormonal response in women, C-peptide for hyperinsulinemia; and triglycerides/high density lipoprotein-cholesterol (TG/HDL) ratio for insulin resistance. In multivariable-adjusted linear regression analyses, we estimated relative concentrations of biomarkers across adherence categories. There was a significant trend of lower (higher for adiponectin) biomarker concentrations with higher adherence to the energy balance recommendations (all P-trend<0.0001). Comparing the highest (3) to the lowest recommendation category (0–1), the percent difference in relative concentrations of biomarkers was CRP, −69%; IL6, −41%; TNFαR2, −13%; adiponectin, +36; C-peptide, −43%; TG/HDL, −43%; estrone, −31%; and estradiol, −43%; in women; and CRP, −59%; IL6, −42%; TNFαR2, −10%; adiponectin, +22%; C-peptide, −44%; and TG/HDL, −40%; in men. In contrast, associations between adherence to the plant, animal foods and alcohol intake recommendations and biomarker concentrations were weaker, and mostly nonsignificant. The healthier biomarker profile associated with greater adherence to the WCRF/AICR cancer prevention recommendations is driven mainly by adherence to the energy balance-related recommendations.

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The role of adipokines in gestational diabetes mellitus

Cited by 60 publications

References 23 publications

The role of visfatin (PBEF/Nampt) in pregnancy complications

The role of visfatin (PBEF/Nampt) in pregnancy complications

Serum adiponectin levels in gestational diabetes mellitus

Associations between adherence to the World Cancer Research Fund/American Institute for Cancer Research cancer prevention recommendations and biomarkers of inflammation, hormonal, and insulin response

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