The role of adipokines in the pathogenesis and course of selected respiratory diseases

Chwalba, Artur; Machura, Edyta; Ziora, Katarzyna; Ziora, Dariusz

doi:10.5603/ep.a2019.0051

Cited by 15 publications

(8 citation statements)

References 39 publications

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“…Elevated body mass index was predictive of the need for hospitalization (169) and related to admission to the intensive care unit (134). The mechanistic link is probably the induction of inflammation by the immune system in the adipose tissue, increasing the vulnerability to develop infections (115) (30), which secrete, among others, adipokines, cytokines, and chemokines with a substantial influence on surrounding tissues, allowing a potential cross-talk with the respiratory system (40). Not only may the adipose tissue serve as a pathogen reservoir for SARS-CoV-2 given its high ACE2 expression (146), but its obesity-associated inflammation likely plays a role in cardiometabolic pathogenesis and, of course, in the aggravation of viral outcomes.…”

Section: Polyphenols and Cardiometabolic Disordersmentioning

confidence: 99%

Can phytotherapy with polyphenols serve as a powerful approach for the prevention and therapy tool of novel coronavirus disease 2019 (COVID-19)?

Lévy

Delvin

Marcil

et al. 2020

American Journal of Physiology-Endocrinology and Metabolism

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Much more serious than the previous severe acute respiratory syndrome (SARS) coronavirus (CoV) outbreaks, the novel SARS-CoV-2 infection has spread speedily, affecting 213 countries and causing ~17,300,000 million cases and ~672,000 (~+1500/day) deaths globally (as of July 31th, 2020). The potentially fatal COVID-19, caused by air droplets and airborne as the main transmission modes, clearly induces a spectrum of respiratory clinical manifestations, but it also affects the immune, gastrointestinal, hematological, nervous and renal systems. The dramatic scale of disorders and complications arise from the inadequacy of current treatments, absence of a vaccine and specific anti-COVID-19 drugs to suppress viral replication, inflammation and additional pathogenic conditions. This highlights the importance of understanding the SARS-CoV-2 mechanisms of actions, and the urgent need of prospecting for new or alternative treatment options. The main objective of the present review is to discuss the challenging issue relative to the clinical utility of plants-derived polyphenols in fighting viral infections. Not only is the strong capacity of polyphenols highlighted in magnifying health benefits, but also the underlying mechanisms are stressed. Finally, emphasis is placed on the potential ability of polyphenols to combat SARS-CoV-2 infection via the regulation of its molecular targets of human cellular binding and replication, as well as through the resulting host inflammation, oxidative stress and signalling pathways.

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Section: Polyphenols and Cardiometabolic Disordersmentioning

confidence: 99%

Can phytotherapy with polyphenols serve as a powerful approach for the prevention and therapy tool of novel coronavirus disease 2019 (COVID-19)?

Lévy

Delvin

Marcil

et al. 2020

American Journal of Physiology-Endocrinology and Metabolism

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show abstract

“…Visfatin and leptin are listed as possible markers for COPD; leptin and resistin are named as proinflammatory factors in tumor cachexia; the apelin-adiponectin axis is researched in pulmonary hypertension, and many adipocytokines are examined in the context of asthma. Despite these promising findings, the data are controversial and limited [27].…”

Section: Can the Lung Interact With Adipose Tissue?mentioning

confidence: 99%

Obesity and the Lung: What We Know Today

et al. 2020

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Obesity is becoming more and more prevalent especially in Western industrial nations. The understanding of adipose tissue as an endocrine organ as well as the detection of adipocytokines – hormones that are secreted from the adipose tissue – gave reason to examine the interactions between adipose tissue and target organs. These efforts have been intensified especially in the context of bariatric surgery as promising weight loss therapy. Interactions between the lung and adipose tissue have rarely been investigated and are not well understood. There are obvious mechanical effects of obesity on lung function explaining the associations between obesity and lung diseases, in particular obesity hypoventilation syndrome, obstructive sleep apnea syndrome, asthma, and chronic obstructive pulmonary disease. The rise in the prevalence of obesity affects the epidemiology of pulmonary diseases as well. The aim of this review is to summarize the current knowledge on interactions, associations, and consequences of obesity and weight loss on lung function and lung diseases. Based on these data, areas for future research are identified.

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“…The adipose tissue is a well-established source of multiple circulating peptides that are responsible for various metabolic effects ( 1 ). Visfatin/NAMPT (nicotinamide phosphoribosyltransferase) has been recently recognized as an important adipocytokine with regulatory, immunomodulating and proinflammatory properties and has been broadly studied in metabolic disorders, neoplasms, and inflammatory conditions ( 2 , 3 , 4 , 5 ). Thyroid hormones also profoundly affect thermogenesis, metabolic rate, food intake and energy expenditure ( 6 ).…”

Section: Introductionmentioning

confidence: 99%

Effect of restoration of euthyroidism on visfatin concentrations and body composition in women

Sawicka‐Gutaj

Zybek-Kocik

Kloska

et al. 2021

Endocrine Connections

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Dysregulation of thyroid function has known impact on body metabolism, however, data regarding metabolic outcome after restoration of thyroid function is limited. Therefore, the aim of the study was to investigate the effect of restoration of euthyroidism on serum visfatin, and its associations with insulin resistance and body composition. This is an observational study with consecutive enrollment. Forty nine hyperthyroid (median age of 34 years) and 44 hypothyroid women (median age of 46 years) completed the study. Laboratory parameters and body composition analysis were assessed before and after the therapy. In the hyperthyroid group, visfatin concentrations increased (p<0.0001), while glucose concentrations decreased (p<0.0001). Total body mass and fat mass in the trunk and limbs significantly increased during the treatment. In the hypothyroid group, significant weight loss resulted from decrease of fat and muscle masses in trunk and limbs. Visfatin serum concentrations positively correlated with total fat mass (r=0.19, p=0.01) and insulin concentrations (r=0.17, p=0.018). In conclusion, restoration of thyroid function is not associated with beneficial changes in body composition, especially among hyperthyroid females.

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The role of adipokines in the pathogenesis and course of selected respiratory diseases

Cited by 15 publications

References 39 publications

Can phytotherapy with polyphenols serve as a powerful approach for the prevention and therapy tool of novel coronavirus disease 2019 (COVID-19)?

Can phytotherapy with polyphenols serve as a powerful approach for the prevention and therapy tool of novel coronavirus disease 2019 (COVID-19)?

Obesity and the Lung: What We Know Today

Effect of restoration of euthyroidism on visfatin concentrations and body composition in women

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