The role of adiponectin in the association between abdominal obesity and type 2 diabetes: a mediation analysis among 232,438 Chinese participants

Abstract

BackgroundAdiposity and adipokines are closely associated with obesity-related metabolic abnormalities, but little is known regarding whether abdominal obesity is linked to type 2 diabetes mellitus (T2DM) through circulating adiponectin levels. Thus, this large-population–based study was designed to investigate the mediating effect of adiponectin in the relationship between abdominal obesity and T2DM.MethodsA total of 232,438 adults who lived in Dongguan, Guangdong Province, China, were enrolled in the present study. The circulating adiponectin concentrations were measured using latex-enhanced immunoturbidimetric assay. The association between circulating adiponectin and other clinical parameters was detected by Spearman’s correlation analysis. Restricted cubic spline (RCS) regression was also used to address the non-linearity of the relationship between waist circumference and diabetes. Mediation analyses of circulating adiponectin were conducted using linear and logistic regression.ResultsSubjects with abdominal obesity had lower levels of circulating adiponectin (P < 0.001). The circulating adiponectin value was inversely related to BMI (r = −0.370, P < 0.001), waist circumference (r = −0.361, P < 0.001), and fasting plasma glucose (r = −0.221, P < 0.001). The RCS plot showed a non-linear relation linking waist circumference with T2DM (P for non-linearity < 0.001). Patients with abdominal obesity presented 2.062 times higher odds of T2DM in comparison with those with non-abdominal obesity (odds ratio, 2.062; 95% confidence interval, 1.969–2.161) after adjusting for confounders. In the mediation analyses, the circulating adiponectin mediated the association between abdominal obesity and T2DM, with a mediation effect of 41.02% after adjustments. The above results were consistent in both men and women.ConclusionThe relationship between abdominal obesity and T2DM is mediated through circulating adiponectin level in adults, suggesting that circulating adiponectin might be a potential predictor for controlling the adverse progression from adiposity to T2DM.

Effects of moderate-intensity combination exercise on increase adiponectin levels, muscle mass, and decrease fat mass in obese women

“…In addition, aerobic training is often associated with more significant energy expenditure, while resistance training is more associated with maintaining muscle mass, which shifts the fat mass composition (Strasser et al, 2012). This optimal fat-burning underlies the increase in circulating adiponectin levels (He, et al, 2024).…”

Association of Circulating Markers of Microbial Translocation and Hepatic Inflammation with Liver Injury in Patients with Type 2 Diabetes

“…Indeed, T2D has been shown to be a risk factor for the development of liver disease and to accelerate its progression to more severe forms of liver disease [ 3 , 4 , 6 , 11 ]. Increased adiposity in T2DM is associated with the dysregulated release of adipokines, adiponectin, resistin, and leptin by white adipose tissue (WAT) [ 47 , 48 ]. Importantly, WAT dysfunction and increased lipolysis due to insulin resistance leads to excess free fatty acid accumulation in the liver, which can cause mitochondrial dysfunction and endoplasmic reticulum stress in hepatocytes and liver injury [ 49 ].…”