The Role of Adjuvant Chemotherapy in Non-Metastatic Goblet Cell Carcinoid of the Appendix: An 11-Year Experience from the National Cancer Database

AlMasri, Samer; Nassour, Ibrahim; Kowalsky, Stacy J.; Hrebinko, Katherine; Singhi, Aatur D.; Lee, Kenneth K; Choudry, Haroon A.; Bartlett, David L.; Zureikat, Amer H.; Paniccia, Alessandro

doi:10.1245/s10434-020-09389-3

Cited by 12 publications

(26 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The rate of rise is increasing in recent years, with another SEER database study finding that only 37.8% of GCA were diagnosed between 2004 and 2009, with the remaining 62.2% diagnosed between 2010 and 2016 ( 16 ). A similar trend was noted in the NCDB analysis, in which 96% of the cases of GCA were seen post-2010 ( 14 ). Other studies note a rising incidence of all NENs, which may be attributable to an increased awareness and coding of these tumours, an increased rate of detection, other factors, or a real rise ( 108 ).…”

Section: Resultssupporting

confidence: 80%

“…The incidence of GCA is increasing ( 3 , 14 , 16 , 17 , 58 , 89 ). In an analysis of the SEER registry between 1973 and 2014, 98.3% of cases were diagnosed between 1994 and 2014 ( 17 ).…”

Section: Resultsmentioning

confidence: 99%

“…Only one large registry study reported a median age out of this range at 43 years ( 23 ). GCA is more common in Caucasian patients, who account for 80-90% cases ( 3 , 11 , 12 , 14 – 20 , 25 , 26 ). There was no sex preponderance in most studies ( 3 , 11 , 12 , 14 , 16 , 18 , 20 , 23 , 25 , 26 ); however, this was variable in the smaller retrospective studies and case series.…”

Section: Resultsmentioning

confidence: 99%

“…GCA is more common in Caucasian patients, who account for 80-90% cases ( 3 , 11 , 12 , 14 – 20 , 25 , 26 ). There was no sex preponderance in most studies ( 3 , 11 , 12 , 14 , 16 , 18 , 20 , 23 , 25 , 26 ); however, this was variable in the smaller retrospective studies and case series. Infection with schistosomiasis was the only potential environmental risk factor identified, although it should be noted that only three cases of combined appendiceal schistosomiasis and GCA were included in this study ( 63 ).…”

Section: Resultsmentioning

confidence: 99%

See 3 more Smart Citations

Goblet Cell Adenocarcinoma of the Appendix: A Systematic Review and Incidence and Survival of 1,225 Cases From an English Cancer Registry

et al. 2022

View full text Add to dashboard Cite

BackgroundGoblet cell adenocarcinoma (GCA) of the appendix is a rare and aggressive tumour with varying nomenclature and classification systems. This has led to heterogeneity in published data, and there is a lack of consensus on incidence, survival, and management.MethodsWe provide an overview of GCA with a comprehensive systematic review using Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) methodology and a retrospective analysis of all cases recorded in the English National Cancer Registration and Analysis Service database between 1995 and 2018. The Kaplan–Meier estimator was used to calculate overall survival, and Cox proportional hazards regression was used to identify prognostic factors.ResultsThe systematic review demonstrated an incidence of 0.05–0.3 per 100,000 per year among North American registry studies. The 1-, 3-, and 5-year survival rate was 95.5%, 85.9%–87.6%, and 76.0%–80.6%, respectively. Age, stage, and grade were identified as prognostic factors for survival. Our analysis included 1,225 cases. Age-standardised incidence was 0.0335 per year in 1995 and gradually rose to 0.158 per year in 2018. The 1-, 3-, and 5-year survival rate was 90.0% [95% confidence interval (95% CI): 85.4–94.0], 76.0% (95% CI: 73.8–80.9), and 68.6% (95% CI: 65.9–72.2), respectively. On univariate Cox regression analyses, female sex, stage, and grade were associated with worse overall survival. On multivariate analysis, only stage remained a statistically significant prognostic factor.ConclusionsGCA of the appendix is rare, but incidence is increasing. We report a lower incidence and survival than North American registry studies. Higher stage was associated with decreased survival. Further prospective studies are required to establish optimal management.

show abstract

Section: Resultssupporting

confidence: 80%

“…The incidence of GCA is increasing ( 3 , 14 , 16 , 17 , 58 , 89 ). In an analysis of the SEER registry between 1973 and 2014, 98.3% of cases were diagnosed between 1994 and 2014 ( 17 ).…”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

Goblet Cell Adenocarcinoma of the Appendix: A Systematic Review and Incidence and Survival of 1,225 Cases From an English Cancer Registry

et al. 2022

View full text Add to dashboard Cite

show abstract

“…59 However, a recent report of the National Cancer Database suggested improved survival for patients with node-positive disease who received adjuvant chemotherapy. 60…”

Section: Managementmentioning

confidence: 99%

Current Management of Appendiceal Neoplasms

Hoehn

Rieser

Choudry

et al. 2021

American Society of Clinical Oncology Educational Book

View full text Add to dashboard Cite

Appendiceal neoplasms include a heterogeneous group of epithelial and nonepithelial tumors that exhibit varying malignant potential. This review article summarizes current diagnostic criteria, classification systems, and optimal therapeutic strategies for the five main histopathologic subtypes of appendiceal neoplasms. In particular, the management of epithelial appendiceal neoplasms has evolved. Although their treatment has historically been extrapolated from colon cancer, improved understanding of their unique histopathologic and molecular characteristics and a growing body of published clinical data support a more nuanced approach to their management.

show abstract

Appendiceal goblet cell carcinoma has marginal advantages from perioperative chemotherapy: a population-based study with an entropy balancing analysis

Ricci

Campana

Ingaldi

et al. 2023

Langenbecks Arch Surg

View full text Add to dashboard Cite

Purpose The aim is to clarify the use of perioperative chemotherapy in resectable goblet cell carcinoma (GCC). Methods A retrospective study was carried out based on the Surveillance, Epidemiology, and End Results study. The population was divided: into patients who received only radical surgery (group A) and those who received radical surgery plus chemotherapy (group B). An entropy balancing was carried out to correct the imbalance between the two groups. Two models were generated. Model 1 contained only high-risk patients: group B and a “virtual” group A with similar characteristics. Model 2 included only low-risk patients: group A and “virtual” group B with identical attributes. The efficacy of entropy balancing was evaluated with the d value. The overall survival was compared and reported with Hazard Ratio (HR) within a confidence interval of 95% (95 CI). Results The groups A and B were imbalanced for tumor size (d = 0.392), T (d = 1.128), N (d = 1.340), M (d = 1.456), mean number of positive lymph nodes (d = 0.907), and LNR (d = 0.889). Before the balancing, the risk of death was higher in group B than in A (4.3; 2.5 to 7.4). After reweighting, all large differences were eliminated (d < 0.200). In high-risk patients, the risk of death was higher in patients who underwent surgery alone than those who received perioperative chemotherapy (HR 0.5; 0.2 to 1.3) without statistical significance (p = 0.187). In low-risk patients, the risk of death was similar (HR 1.1; 0.3 to 3.3). Conclusion Perioperative chemotherapy could provide some marginal advantages to high-risk patients.

show abstract

The Role of Adjuvant Chemotherapy in Non-Metastatic Goblet Cell Carcinoid of the Appendix: An 11-Year Experience from the National Cancer Database

Cited by 12 publications

References 25 publications

Goblet Cell Adenocarcinoma of the Appendix: A Systematic Review and Incidence and Survival of 1,225 Cases From an English Cancer Registry

Goblet Cell Adenocarcinoma of the Appendix: A Systematic Review and Incidence and Survival of 1,225 Cases From an English Cancer Registry

Current Management of Appendiceal Neoplasms

Appendiceal goblet cell carcinoma has marginal advantages from perioperative chemotherapy: a population-based study with an entropy balancing analysis

Contact Info

Product

Resources

About