The Role of Adjuvants and Delivery Systems in Modulation of Immune Response to Vaccines

Gupta, Rajesh K.; Griffin, Paul; Chang, Alice B.; Rivera, Rachel; Anderson, Roger W.; Rost, Bradford; Cecchini, Douglas J.; Nicholson, Mary R.; Siber, George R.

doi:10.1007/978-1-4899-1382-1_15

Cited by 24 publications

(9 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…On the other hand, induction of a type-1 response can provide subsequent help in setting up CTL responses. Pathogens and, in a lesser extend, immunomodulators or adjuvants are known to selectively polarize the immune response by interfering with toll-like receptors on DC and by acting on interleukine secretion from APC (Okamoto and Sato 2003; Gupta et al 1996). For example, saponin adjuvants such as QS 21, monophosphoryl lipid A, and unmethylated bacterial CpG-DNA are associated with Th1 responses (Moore, McCarthy, and Mills 1999;Persing et al 2002;Jakob et al 1999) while aluminum salts are related to type-2 profile and fail to induce CTL responses.…”

Section: Isotypic Distributionmentioning

confidence: 98%

Amplification of Antibody Responses to Antigen Using Small Multilamellar Vesicles for Delivery System

Gaubert

Delord²,

Roux³

et al. 2005

Drug Delivery

View full text Add to dashboard Cite

New vaccines based on subunits, synthetic peptides, or DNA need innovative adjuvants or antigen delivery systems: Spherulites are multilamellar vesicles made of incompatible lipid bilayers without any aqueous core. In this study, we evaluated their ability to induce immune responses against human serum albumin (HSA). Mice were immunized by the intraperitoneal/intravenous route or subcutaneously with HSA without any adjuvant or in its encapsulated form. We showed that Spherulites strongly enhanced the seric antibody responses and led to a mixed isotypic distribution characterized by an IgG(2a) potentiation. This demonstrated that Spherulites can improve the presentation of weak antigens to the immune system.

show abstract

Section: Isotypic Distributionmentioning

confidence: 98%

Amplification of Antibody Responses to Antigen Using Small Multilamellar Vesicles for Delivery System

Gaubert

Delord²,

Roux³

et al. 2005

Drug Delivery

View full text Add to dashboard Cite

show abstract

“…Adjuvants are associated with the induction of cellular and humoral adaptive immune responses, and so can also be referred to as immuno-enhancers. They may increase the ability of antigens to activate signaling pathways to control the induction of innate and adaptive immunity, predominantly targeting APCs [6][7][8][9][10][11]. For over 70 years, aluminum salts (Alum) have been used as adjuvants in human vaccines [12,13].…”

Section: Q2mentioning

confidence: 99%

“…Mice (n = 5) were intramuscularly immunized twice at a 2-week interval with the indicated amount of antigen alone or together with adjuvant in 50 l PBS. Antibody titer: (a) IgG, (b) IgG1, (c) IgG2c were measured by ELISA [(1,4,7,10); antigen alone,(2,5,8,11); HBsAg Alum,(3,6,9,12); HBsAg Alum MPLA/HA].…”

mentioning

confidence: 99%

Evaluation of hyaluronic acid-based combination adjuvant containing monophosphoryl lipid A and aluminum salt for hepatitis B vaccine

Moon

Shin

Noh

et al. 2015

Vaccine

View full text Add to dashboard Cite

“…Due to the preferential Th2 bias of the neonate and increased susceptibility to infections, there has been continued interest in identifying safe adjuvants that stimulate Th1 immunity. Currently approved adjuvants such as alum are poor stimulators of Th1 immunity, which is believed to be a crucial component of host defense against viruses (47). There is interest in the use of DNA vaccination to induce protective immunity in neonatal animals.…”

Section: Figurementioning

confidence: 99%

Neonatal Administration of IL-12 Enhances the Protective Efficacy of Antiviral Vaccines

Arulanandam

Mittler

Lee

et al. 2000

The Journal of Immunology

View full text Add to dashboard Cite

Neonates are highly susceptible to infectious agents and are known to display polarized expression of Th2-like cytokines and Abs. This neonatal immune bias has important implications for the development of vaccine strategies, particularly against viral infections. We now report that coadministration of IL-12 and an influenza subunit vaccine at birth enhances the protective efficacy of antiviral vaccination. Immunization and treatment with IL-12 within 24 h of birth resulted in elevated expression of IFN-γ, IL-10, and IL-15 mRNA in the spleens of newborn mice compared with animals exposed to vaccine only. In addition, these animals showed dramatic increases in IFN-γ-, IL-2-, and IL-4-secreting cells, and in IgG2a Ab levels upon adult challenge compared with mice primed with vaccine alone. Most importantly, animals vaccinated and simultaneously treated with IL-12 at birth displayed enhanced survival after lethal challenge with infectious influenza virus as adults compared with infected animals that had been primed with vaccine alone. This augmented protection required B cells and could be transferred to naive mice by immune serum. Collectively, these results provide evidence that administration of IL-12 to neonates induces a Th1-like response in newborns and elicits protective antiviral immune memory.

show abstract

The Role of Adjuvants and Delivery Systems in Modulation of Immune Response to Vaccines

Cited by 24 publications

References 27 publications

Amplification of Antibody Responses to Antigen Using Small Multilamellar Vesicles for Delivery System

Amplification of Antibody Responses to Antigen Using Small Multilamellar Vesicles for Delivery System

Evaluation of hyaluronic acid-based combination adjuvant containing monophosphoryl lipid A and aluminum salt for hepatitis B vaccine

Neonatal Administration of IL-12 Enhances the Protective Efficacy of Antiviral Vaccines

Contact Info

Product

Resources

About