The role of adolescent sleep quality in the development of anxiety disorders: A neurobiologically-informed model

General additive models address statistical issues in diffusion MRI: An example with clinically anxious adolescents

“…If greater uncinate FA values in High relative to Low anxiety groups are indeed the result of “increased structural integrity”, rather than a reflection of decreased local intermixing, then one possible interpretation would be that clinical anxiety in this population is associated with greater availability of emotionally valenced information resulting from more efficient amygdaloid-frontal connectivity via uncinate projections ( Heide et al, 2013 , Eden et al, 2015 , Baur et al, 2012 ). To find convergence with the extant literature, then, it is possible that myelination could subsequently be affected in later pubertal development, resulting in the typically observed negative correlation of uncinate FA values and anxiety, possibly due to the adverse effects of hypercortisolaemia on myelination ( Piasecka et al, 2020 , Chen et al, 2020 , Wong et al, 2013 , Garg and Mittal, 2020 , Jamieson et al, 2021 ), but this is conjecture.…”

“…Previous work has consistently detected a negative relationship between the left uncinate FA values and measures of anxiety, and often interpret such a relationship as suggestive of insufficient executive down-regulation of limbic systems (e.g. Tromp et al, 2012 , Liao et al, 2014 , Hanson et al, 2015 , Ho et al, 2017 , Hein et al, 2018 , Jamieson et al, 2021 ). A number of differences set our work apart from previous studies, however, and while a full methodological investigation of the impact of differing processing pipelines, software, and statistical models on the uncinate-anxiety outcomes is beyond the scope of this paper, we postulate that the unique characteristics of this study and dataset explain our discrepant findings: (A) Rather than recruit convenience samples of an adolescent population and subsequently administer anxiety assessments, we recruited clinically anxious periadolescent individuals from pediatric anxiety clinics in addition to the no-psychiatric-diagnosis control participants.…”

“…By default pyAFQ generates a set of 18 tracts and, given the aims of the parent R01 ( McMakin et al, 2021 ), three pathways were selected for modeling and testing: the left uncinate fasciculus, the right uncinate fasciculus, and the anterior forceps. The left and right uncinate were selected for their connection with sleep, anxiety, development, and potential link with memory ( Jamieson et al, 2021 , Granger et al, 2021 ), while the anterior forceps were selected as a control region due to its similarity in curvature with the uncinate fasciculi ( Fig. 1 ).…”

“…Clinically, mental health, injury, and/or disease often are associated with white matter disruption (e.g. traumatic brain injury, multiple sclerosis, anxiety), and classification of these differences may serve as strong etiological biomarkers ( Harrison et al, 2011 , De Santis et al, 2019 , Mesaros et al, 2012 , Shenton et al, 2012 , Hutchinson et al, 2018 , Raizman et al, 2020 , Delouche et al, 2016 , Adluru et al, 2017 , Jamieson et al, 2021 ). Additionally, developmental research will benefit from careful modeling given the role of myelination in both development and DWI metrics ( Dumontheil, 2016 , Østby et al, 2009 ).…”

Comparison of Pain in Male Drug Rehabilitees with and without Human Immunodeficiency Virus in Yunnan Province, China

“…The difference may be because the participants in our investigation used a variety of drugs, rather than just morphine. Additionally, other factors, such as illicit drug use or psychological distress, may explain the reduced sleep quality for these patients, as these factors have been reported to affect sleep [ 28 , 29 ]. These reports indicate that pain is significantly related to sleep quality, suggesting that analgesic treatment for drug addicts in drug rehabilitation centers may be effective.…”