The role of ADRB2 gene polymorphisms in malignancies

et al. 2022

Sci Rep

The gene encoding beta2-adrenergic receptor (β2-AR), adrenoceptor beta 2 (ADRB2), has been reported to closely associated with various cancers. However, its role in lung adenocarcinoma (LUAD) remains controversial. This research shed light on the prognostic value of ADRB2 in LUAD and further explored its association with immune cell infiltration. ADRB2 was significantly decreased in LUAD. ADRB2 expression in LUAD was significantly correlated with gender, smoking status, T classification, and pathologic stage. Patients in the low ADRB2 expression group presented with significantly poorer overall survival (OS) and disease-specific survival (DSS). Kyoto Encyclopedia of Genes and Genomes (KEGG) and Gene Set Enrichment Analysis (GSEA) results showed that ADRB2 participates in immune response. The expression of ADRB2 was positively correlated with the infiltration level of most immune cells. Notably, ADRB2 is involved in LUAD progression partly by regulating the immune microenvironment, which may potentially serve as a significant prognostic biomarker as well as a potential drug target.

Section: Discussionmentioning

confidence: 99%

ADRB2 expression predicts the clinical outcomes and is associated with immune cells infiltration in lung adenocarcinoma

et al. 2022

Sci Rep

“…Cytotoxic T lymphocytes (TILs) are major players in antitumor immunity and can lead to apoptosis of cancer cells through a series of steps; therefore, high in ltration of TILs is a favorable prognostic marker for many cancers. DCs are the most effective antigen-presenting cells to induce primary tumor immune response (20), and in NSCLC patients, an increased DC count was signi cantly associated with an increase in DSS (21). The role of macrophages in cancer progression is still controversial.…”

Section: Discussionmentioning

confidence: 99%

“…Due to polymorphism, there is signi cant genetic variation in β2-AR structure in human populations. Dennis W. McGraw et al20 found that the C variant at rs1042711 is association with the down-regulation of β2-AR expression. Polymorphisms of ADRB2 in the 5′UTR and promoter region would causes a down-modulation of ADRB2 expression which in turn promotes onset of malignancies21 .…”

mentioning

confidence: 99%

ADRB2 Expression Predicts the Clinical Outcomes and is Associated with Immune Cells Infiltration in Lung Adenocarcinoma

et al. 2022

Preprint

The gene encoding beta2-adrenergic receptor (β2-AR), adrenoceptor beta 2 (ADRB2), has been reported to closely associated with various cancers. However, its role in lung adenocarcinoma (LUAD) remains controversial. This research shed light on the prognostic value of ADRB2 in LUAD and further explored its association with immune cell infiltration. ADRB2 was significantly decreased in LUAD. ADRB2 expression in LUAD was significantly correlated with gender, smoking status, T classification, lymph node metastasis, and pathologic stage. Patients in the low ADRB2 expression group presented with significantly poorer overall survival (OS) and disease-specific survival (DSS). Kyoto Encyclopedia of Genes and Genomes (KEGG) and Gene Set Enrichment Analysis (GSEA) results showed that ADRB2 participates in immune response. The expression of ADRB2 was positively correlated with the infiltration level of most immune cells. Notably, ADRB2 is involved in LUAD progression partly by regulating the immune microenvironment, which may potentially serve as a significant prognostic biomarker as well as a potential drug target.

“…Te gastrointestinal tract is often injured under stress in the human body [14], such as by stress ulcers. Adrenoceptor beta 2 (ADRB2) is an important member of seven transmembrane G protein-coupled receptors that can be activated by β-agonists such as epinephrine, norepinephrine, and isoproterenol [15]. Recent studies have found that ADRB2 signaling can regulate a variety of cells in the tumor microenvironment and activate cancer-related signaling pathways [16].…”

Section: Introductionmentioning

confidence: 99%

ADRB2 Regulates the Proliferation and Metastasis of Gastrointestinal Stromal Tumor Cells by Enhancing the ETV1-c-KIT Signaling

Chen

et al. 2023

Journal of Oncology

Background. Gastrointestinal stromal tumor (GIST) originates from a pacemaker cell, the Cajal cell. However, little is known about the cancer neuroscience in GIST. In this study, we aimed to elucidate the clinical and biological roles of adrenoceptor beta 2 (ADRB2) in GIST. Methods. Immunohistochemistry was used to evaluate the expression of ADRB2 in GIST tissues. The biological effects of ADRB2 on GIST cell proliferation, migration, invasion, and apoptosis were explored using Cell Counting Kit −8, plate colony formation assay, transwell invasion assay, and flow cytometry. We also explored the growth and metastasis of xenograft tumors in nude mice. Western blotting was used to quantify protein expression and phosphorylation. Results. ADRB2 is generally highly expressed in GIST. High ADRB2 expression was significantly associated with risk level, tumor size, mitotic count, and metastasis. Overexpression of ADRB2 promoted GIST cell proliferation, migration, invasion, and apoptosis, while silencing ADRB2 expression showed the opposite effects. Furthermore, we found that silencing endogenous ADRB2 inhibited GIST progression and metastasis in nude mice. ADRB2-induced ETV1 upregulation enhanced the activation of c-KIT. Conclusion. ADRB2 plays an important role in the proliferation and metastasis of GIST and is expected to be a potential target for the treatment of GIST.