The role of advanced neuroimaging in intracerebral hemorrhage

McDowell, Michael M.; Kellner, Christopher P.; Barton, Sunjay M.; Mikell, Charles B.; Sussman, Eric S; Heuts, Simon G.; Connolly, E. Sander

doi:10.3171/2013.1.focus12409

Cited by 11 publications

(10 citation statements)

References 55 publications

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“…20,21 Intracranial hemorrhage damages these connections. 22 The degree of loss of cortical projections to or through the striatum was measured by back-labeling all of the cortical axons that project to the site of the ICH with the axonal tracer CTb, within the collagenase or blood injection, and then measuring the retrogradely labeled cell bodies. This approach labels cells that project to or through the hemorrhagic lesion, 23 allowing a quantification of the effect of the ICH on network connectivity of the overlying cortex.…”

Section: Infarct Volume and Tissue Damagementioning

confidence: 99%

Mouse Intracerebral Hemorrhage Models Produce Different Degrees of Initial and Delayed Damage, Axonal Sprouting, and Recovery

Barratt

Lanman

Carmichael

2014

J Cereb Blood Flow Metab

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The mechanisms of delayed damage and recovery after intracerebral hemorrhage (ICH) remain poorly defined. Two rodent models of ICH are commonly used: injection of the enzyme collagenase (cICH) and injection of autologous blood (bICH). In mice, we compared the effects of these two models on initial and delayed tissue damage, motor system connections, and behavioral recovery. There is no difference in lesion size between models. Injection of autologous blood causes greater mass effect and early mortality. However, cICH produces greater edema, inflammation, and cell death. Injection of the enzyme collagenase causes greater loss of cortical connections and secondary shrinkage of the striatum. Intracerebral hemorrhage occurs within the motor system connections of the striatum. Mapping of the projections of the forelimb motor area shows a significant sprouting in motor cortex projections only in cICH. Both models of ICH produce deficits in forelimb motor control. Behavioral recovery occurs by 5 weeks in cICH and 9 weeks in bICH. In summary, cICH and bICH differ in almost every facet of initial and delayed stroke pathophysiology, with cICH producing greater initial and secondary tissue damage and greater motor system axonal sprouting than bICH. Motor recovery occurs in both models, suggesting that motor system axonal sprouting in cICH is not causally associated with recovery.

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Section: Infarct Volume and Tissue Damagementioning

confidence: 99%

Mouse Intracerebral Hemorrhage Models Produce Different Degrees of Initial and Delayed Damage, Axonal Sprouting, and Recovery

Barratt

Lanman

Carmichael

2014

J Cereb Blood Flow Metab

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“…DTI can be used to detect disturbances to the integrity and iber counts of white mater tract, often damaged in ICH. Reduced fractional anisotropy or iber counts may suggest worsened outcomes [15]. DTI can be used to predict motor recovery, as patients with preserved tracts on DTI at the time of lesion have shown greater recovery than their counterparts with compromised tracts [16] with similar studies being carried out using fractional anisotropy.…”

Section: Detecting Etiologymentioning

confidence: 99%

“…This could be utilized to predict the occurrence of ICH in patients of cerebral amyloid angiopathy (CAA) using PET and difusion tensor imaging (DTI) [15].…”

Section: Side Efectsmentioning

confidence: 99%

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Neuroimaging in Intracerebral Hemorrhage

Mirza¹,

Gokhale²

2017

Hemorrhagic Stroke - An Update

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Hemorrhagic stroke accounts for 15% of all strokes but results in nearly a third of the mortality. Neuroimaging forms the mainstay in diagnosis, which has resulted in improved treatment outcomes. The mandate of neuroimaging includes management, risk assessment, prognostication, and research. This involves rapid identiication not only to direct treatment but also to discover the underlying etiology such as vascular malformations or tumors, monitor the evolving course of the hemorrhage and rapidly identify complications. While computed tomography (CT) remains the imaging of choice to rapidly detect acute hemorrhage, growing evidence shows that magnetic resonance imaging (MRI) is comparable to CT for detecting blood in the immediate seting and superior in this regard at subacute and chronic time points. Several advances have been made in the image sequencing protocols to detect bleeds at varying time points and to distinguish possible etiology. Initial and serial imaging is used to identify patients who may beneit from intervention. Advances in this ield such as difusion tensor imaging and functional MRI are being studied for their impact in understanding the extent of injury and possible recovery mechanisms, possibly allowing prognostication for patients.

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“…Preclinical ICH models have greatly improved our knowledge of the pathophysiology of ICH and have been a valuable tool for testing potential therapeutic strategies [4]. In particular, transgenic mouse models are helpful for addressing genetic influences on early brain injury and late brain repair after ICH [5].…”

Section: Introductionmentioning

confidence: 99%

Intracerebral haemorrhage-induced injury progression assessed by cross-sectional photoacoustic tomography

Yang

Zhang

et al. 2017

Biomed. Opt. Express

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Abstract:In this study, we in vivo examined injury progression after intracerebral haemorrhage (ICH) induced by collagenase in mice using cross-sectional photoacoustic tomography (csPAT). csPAT displayed high resolution with high sensitivity for ICH detection. The PAT images obtained showed high correlation with conventional histologic images. Quantitative analysis of the hematoma areas detected by csPAT showed high consistency with the neurologic deficit score (NDS). By utilizing the dual-wavelength method, the development of the hemoglobin area was monitored. Our results indicated that noninvasive csPAT can be used to track the dynamic progression of post-ICH, and to evaluate therapeutic interventions in preclinical ICH models. Wagner, "European Stroke Organisation (ESO) guidelines for the management of spontaneous intracerebral hemorrhage," Int. J. Stroke 9(7), 840-855 (2014). 2. C. J. van Asch, M. J. Luitse, G. J. Rinkel, I. van der Tweel, A. Algra, and C. J. Klijn, "Incidence, case fatality, and functional outcome of intracerebral haemorrhage over time, according to age, sex, and ethnic origin: a systematic review and meta-analysis," Lancet Neurol. 9(2), 167-176 (2010). 3. J. Yang, Q. Li, Z. Wang, C. Qi, X. Han, X. Lan, J. Wan, W. Wang, X. Zhao, Z. Hou, C. Gao, J. R. Carhuapoma, S. Mori, J. Zhang, and J. Wang, "Multimodality MRI assessment of grey and white matter injury and blood-brain barrier disruption after intracerebral haemorrhage in mice," Sci.

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The role of advanced neuroimaging in intracerebral hemorrhage

Cited by 11 publications

References 55 publications

Mouse Intracerebral Hemorrhage Models Produce Different Degrees of Initial and Delayed Damage, Axonal Sprouting, and Recovery

Mouse Intracerebral Hemorrhage Models Produce Different Degrees of Initial and Delayed Damage, Axonal Sprouting, and Recovery

Neuroimaging in Intracerebral Hemorrhage

Intracerebral haemorrhage-induced injury progression assessed by cross-sectional photoacoustic tomography

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