2020
DOI: 10.1007/s00424-020-02354-9
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The role of afferent renal denervation in renovascular hypertension—another brick in the wall

Abstract: All in all, merging their favourable pre-clinical results with currently available clinical data provides a strong incentive to further explore catheter-based RDN as a therapeutic approach in CKD and other diseases related to sympathetic hyperactivity.

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“…Other than triggering RAAS, UA has been shown to induce hypertension through a crystal and pressure-independent kidney afferent arteriolopathy [ 27 , 28 , 29 ]. Afferent arteriolopathy can indeed lead to impaired renal blood flow, ischemia, and consequent renovascular hypertension [ 75 , 76 ]. However, the exact mechanism whereby UA can induce arteriolopathy remains partially unsolved.…”
Section: Discussionmentioning
confidence: 99%
“…Other than triggering RAAS, UA has been shown to induce hypertension through a crystal and pressure-independent kidney afferent arteriolopathy [ 27 , 28 , 29 ]. Afferent arteriolopathy can indeed lead to impaired renal blood flow, ischemia, and consequent renovascular hypertension [ 75 , 76 ]. However, the exact mechanism whereby UA can induce arteriolopathy remains partially unsolved.…”
Section: Discussionmentioning
confidence: 99%