The role of age, genotype, sex, and route of acute and chronic administration of methylphenidate: A review of its locomotor effects

Methylphenidate treatment in the spontaneously hypertensive rat: influence on methylphenidate self-administration and reinstatement in comparison with Wistar rats

“…The findings in SHR lend further support to the assumption that genetic variability affects responses to psychostimulants (for review, see Dafny and Yang 2006) and, more importantly, provide additional insight into the age-long debate on the safety or addiction liability of methylphenidate therapy in ADHD. It is known that experimental animals, and even humans, display significant individual variability both in the initial behavioral response to psychostimulants and in the development of tolerance and/or sensitization (Segal and Kuczenski 1987;Post et al 1988;Cailhol and Mormede 1999).…”

Sensitivity to apomorphine-induced yawning and hypothermia in rats eating standard or high-fat chow

“…These results also provide some of the first evidence showing conditioning to drug-induced yawning, an effect that might mask diet-induced differences in the development of sensitization to apomorphine-induced yawning. Although many factors can impact sensitivity to the behavioral effects of drugs (Dafny and Yang 2006), together with a growing body of literature, these results clearly support the view that eating conditions modify the behavioral effects of drugs acting on dopamine systems in a manner that might be relevant to understanding individual differences in response to recreational as well as therapeutic drug use (Carroll et al 1981;Goodwin et al 1987).…”

Evaluation of histopathologic and histomorphometric changes of testicular tissue and gonadotropin levels following consumption of methylphenidate in male mice

“…Humans who were administered MPH systemically reported similarities in the reinforcing effects of MPH to those of cocaine or amphetamine. Moreover, MPH has a higher mortality rate than cocaine and amphetamine when taken systemically (21)(22)(23)(24)(25)(26). In a study carried out on the effect of MPH on the fertility of male mice, it was indicated that MPH could significantly decrease fertility (16).…”