The role of aging in cancer

Havas, Aaron; Yin, Shanshan; Adams, Peter D.

doi:10.1002/1878-0261.13302

Cited by 10 publications

(4 citation statements)

References 92 publications

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“…(2) These findings may aid future research on IR and BA and aging. (3) Aging is an important cause for many disorders [ 58 ], such as Alzheimer's disease (AD) [ 59 ], Parkinson′s disease [ 60 ], and cancer [ 61 ]. Expanding our understanding of the biological processes that promote rapid aging may result in efficient interventions.…”

Section: Discussionmentioning

confidence: 99%

HOMA-IR is positively correlated with biological age and advanced aging in the US adult population

Yang,

Gong,

Liu

et al. 2023

Eur J Med Res

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Background Insulin resistance (IR) had been reported to be associated with age; however, few studies have explored the association between IR and biological age (BA). The HOMA-IR value is a useful indicator of the extent of IR. This cross-sectional study is to explore the relationship between HOMA-IR and BA/advanced aging in the US population. Methods This study is a cross-sectional analysis of National Health and Nutrition Examination Survey (NHANES) data. The survey comprised 12,266 people from the NHANES, and their full HOMA-IR data as well as BA data were extracted. Four multiple linear regressions were performed to analyze the association between HOMA-IR and BA, and four multiple logistic regression models were performed to analyze the association between HOMA-IR and advanced aging. In addition, trend tests and stratified analysis were performed and smoothed fitted curves were plotted to test the robustness of the results. Results HOMA-IR was positively correlated with BA [β: 0.51 (0.39, 0.63)], and it was the same to advanced aging [OR: 1.05 (1.02, 1.07)], and both showed a monotonically increasing trend. The trend tests showed that the results were stable (all P for trend < 0.0001). The smoothed fitted curves showed that there were non-linear relationships between HOMA-IR and BA/advanced aging. And the stratified analysis indicated that the relationship between HOMA-IR and BA/advanced aging remained robust in all subgroups. Conclusion The study suggested that HOMA-IR is positively correlated with BA and advanced aging in the US adult population, with a monotonic upward trend. This is a new finding to reveal the relationship between HOMA-IR and age from new standpoint of BA rather than chronological age (CA). And it may contribute to a better understanding of human health aging and may aid future research in this field.

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Section: Discussionmentioning

confidence: 99%

HOMA-IR is positively correlated with biological age and advanced aging in the US adult population

Yang,

Gong,

Liu

et al. 2023

Eur J Med Res

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“…According to our knowledge, telomere shortening is one of the most important markers of ageing. 19,33,34 Furthermore, cancer cells have typically short telomeres 18,20,21 , as also shown for MM. 23 However, the presence of telomerase reactivation in MM 22 allows for an unlimited cell division potential and telomere length maintenance, which, on the contrary, does not occur in non-neoplastic cells, 35 potentially contributing to the observed results.…”

Section: Discussionmentioning

confidence: 70%

Telomere length and TERT polymorphisms as biomarkers in asbestos-related diseases

Mervic,

Goricar,

Blagus

et al. 2024

Radiology and Oncology

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Background Asbestos exposure has been proposed as a risk factor for shorter telomere length. The aim of our study was to investigate whether telomere length in leukocytes and hTERT genetic polymorphisms may serve as potential biomarkers for the risk of developing asbestos-related diseases and as biomarkers of progression and chemotherapy response rate in malignant mesothelioma (MM). Subjects and methods We conducted two retrospective studies. In the first study, a case-control study, telomere length and hTERT polymorphisms were determined in patients with MM, subjects with pleural plaques and controls without the asbestos related disease, who were occupationally exposed to asbestos. In the second study, a longitudinal observational study, telomere length was also determined in samples from MM patients before and after chemotherapy. Telomere length was determined by monochromatic multiplex quantitative polymerase chain reaction (PCR), while competitive allele-specific PCR was used to genotype hTERT rs10069690, rs2736100 and rs2736098. Logistic regression and survival analysis were used in statistical analysis. Results Patients with MM had shorter telomere length than subjects with pleural plaques (p < 0.001). After adjustment for age, rs2736098 CT, and rs10069690 TT and CT+TT genotypes were significantly associated with a higher risk of MM (padj = 0.023; padj = 0.026 and padj = 0.017), while rs2736100 AA and CA+AA genotypes conferred to a lower risk for MM compared to all other subjects (padj = 0.017, and padj = 0.026). Telomere length was not associated with a response to chemotherapy (p > 0.05) or time to disease progression (p > 0.05). Carriers of one or two polymorphic rs10069690 T alleles had a good response to chemotherapy (p = 0.039, and p = 0.048), these associations remained statistically significant after adjustment for age (padj = 0.019; padj = 0.017). Carriers of two polymorphic rs2736100 A alleles had a longer time to disease progression (p = 0.038). Conclusions Shorter telomere length and hTERT polymorphisms may serve as a biomarker for the risk of developing MM. Additionally, rs10069690 and rs2736100 polymorphisms, but not telomere length, were associated with a chemotherapy response or MM progression.

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“…Age is known to affect various aspects of tumor, including its growth mode, genomic stability, protein homeostasis, tissue repair ability, metabolism, intercellular communication, etc. [ 44 ]. Prior research has shown that old age is an adverse factor for survival and an independent risk factor for lethal nasopharyngeal necrosis after NPC re-irradiation [ 45 , 46 ].…”

Section: Discussionmentioning

confidence: 99%

Prognostic model on overall survival in elderly nasopharyngeal carcinoma patients: a recursive partitioning analysis identifying pre-treatment risk stratification

et al. 2023

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Background We aimed to evaluate the optimal management for elderly patients with nasopharyngeal carcinoma (NPC) with intensity-modulated radiotherapy (IMRT). Methods A total of 283 elderly patients with NPC diagnosed from 2015 to 2019 were enrolled in the study. Overall survival (OS) was the primary endpoint. Univariate and multivariate Cox regression analyses were preformed to identify potential prognostic factors. The recursive partitioning analysis (RPA) was used for risk stratification. Kaplan-Meier survival curves were applied to evaluate the survival endpoints, and log-rank test was utilized to assess differences between groups. The prognostic index (PI) was constructed to further predict patients’ prognosis displayed by nomogram model. The area under the receiver operating characteristic (ROC) curves (AUC) and the calibration curves were applied to assess the effectiveness of the model. Results Based on RPA-based risk stratification, we demonstrated that elderly NPC patients who were treated with IC followed by RT had similar OS as those with induction chemotherapy (IC) combined with concurrent chemoradiotherapy (CCRT) in the middle- (stage I-III and pre-treatment EBV > 1840 copies/ml) and high-risk groups (stage IVA). IMRT alone may be the optimal treatment option for the low-risk group (stage I-III with pre-treatment EBV ≤ 1840 copies/ml). We established an integrated PI which was indicted with stronger prognostic power than each of the factors alone for elderly NPC patients (The AUC of PI was 0.75, 0.80, and 0.82 for 1-, 3-, 5-year prediction of OS, respectively). Conclusion We present a robust model for clinical stratification which could guide individual therapy for elderly NPC patients.

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The role of aging in cancer

Cited by 10 publications

References 92 publications

HOMA-IR is positively correlated with biological age and advanced aging in the US adult population

HOMA-IR is positively correlated with biological age and advanced aging in the US adult population

Telomere length and TERT polymorphisms as biomarkers in asbestos-related diseases

Prognostic model on overall survival in elderly nasopharyngeal carcinoma patients: a recursive partitioning analysis identifying pre-treatment risk stratification

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