The Role of AhR in the Hallmarks of Brain Aging: Friend and Foe

Ojo, Emmanuel S.; Tischkau, Shelley A.

doi:10.3390/cells10102729

Cited by 40 publications

(24 citation statements)

References 144 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…AhR mediates the effects of these substances through the arachidonic acid pathway, cell differentiation, intercellular adhesion interactions, cytokine expression, and mucin production. Human bronchial epithelial cells are reported to express AhR, and AhR activation induces mucin production via reactive oxygen species [ 277 , 279 , 282 , 283 , 284 ].…”

Section: Ahr In the Pathogenesis Of Diseases Related To Oxidative Stressmentioning

confidence: 99%

“…AhR activation can influence the inflammatory phase in both asthma and chronic obstructive pulmonary disease through inflammatory and resident cells in the lungs [ 282 , 284 ]. The relation between AhR function and airway inflammation in the initial phase is important not only in chronic obstructive pulmonary disease but also in asthma.…”

Section: Ahr In the Pathogenesis Of Diseases Related To Oxidative Stressmentioning

confidence: 99%

See 1 more Smart Citation

Aryl Hydrocarbon Receptor in Oxidative Stress as a Double Agent and Its Biological and Therapeutic Significance

Grishanova

Perepechaeva

2022

IJMS

View full text Add to dashboard Cite

The aryl hydrocarbon receptor (AhR) has long been implicated in the induction of a battery of genes involved in the metabolism of xenobiotics and endogenous compounds. AhR is a ligand-activated transcription factor necessary for the launch of transcriptional responses important in health and disease. In past decades, evidence has accumulated that AhR is associated with the cellular response to oxidative stress, and this property of AhR must be taken into account during investigations into a mechanism of action of xenobiotics that is able to activate AhR or that is susceptible to metabolic activation by enzymes encoded by the genes that are under the control of AhR. In this review, we examine various mechanisms by which AhR takes part in the oxidative-stress response, including antioxidant and prooxidant enzymes and cytochrome P450. We also show that AhR, as a participant in the redox balance and as a modulator of redox signals, is being increasingly studied as a target for a new class of therapeutic compounds and as an explanation for the pathogenesis of some disorders.

show abstract

Section: Ahr In the Pathogenesis Of Diseases Related To Oxidative Stressmentioning

confidence: 99%

Section: Ahr In the Pathogenesis Of Diseases Related To Oxidative Stressmentioning

confidence: 99%

Aryl Hydrocarbon Receptor in Oxidative Stress as a Double Agent and Its Biological and Therapeutic Significance

Grishanova

Perepechaeva

2022

IJMS

View full text Add to dashboard Cite

show abstract

“…Recently, the AhR, an ancient protein that possesses highly conserved functions across various species, has been associated with brain aging and age-associated diseases [18,42]. Apart from its well-described role in xenobiotic metabolism, AhR plays a critical role in the developing nervous system of invertebrates and vertebrates.…”

Section: Fig 3 Efferent and Afferent Control Of Cardiac Function [43]mentioning

confidence: 99%

Relationships between plasma levels of nitrogenous metabolites and some psycho-neuro-endocrine parameters

Bombushkar

Гоженко

Корда

et al. 2022

J Educ Health Sport

View full text Add to dashboard Cite

Background. It was recently shown by our group that bilirubin has a neurotropic activity. It is also shown that endogenous uric acid exerts a noticeable modulating effect on neuro-endocrine adaptation factors. In this study, we supplemented the constellation both of subjects of influence with other nitrogenous metabolites - urea and creatinine, and the objects of influence - with plasma levels of the main adaptation hormones and the severity of trait and reactive anxiety. Materials and Methods. The object of observation were almost healthy volunteers: 30 females (30÷76 y) and 31 males (24÷69 y). In basal conditions determined plasma levels of nitrogenous metabolites as well as cortisol, aldosterone, testosterone, triiodothyronine and calcitonin, estimated the severity of the trait and reactive anxiety, recorded the ongoing HRV and EEG. After 4 or 7 days, repeated testing was performed. Results. By constructing regression models, it was found that direct bilirubin determines the levels of psycho-neuro-endocrine parameters by 66,0%, free bilirubin by 56,7%, uric acid by 40,8%, creatinine by 37,6%, and urea - by 31,1%. Taken together, nitrogenous plasma metabolites determine the severity of trait, but not reactive anxiety, plasma levels of testosterone, cortisol and triiodothyronine, but not calcitonin and aldosterone, as well as a number of HRV and EEG parameters by 70,6%. Conclusion. Nitrogenous plasma metabolites, even in the absence of uremia, are able to influence the state of the psyche, autonomic and central nervous and endocrine systems, apparently through aryl hydrocarbon and adenosine receptors of neurons and endocrinocytes and/or directly.

show abstract

“…GH also possesses XRE sequences in its promoter, for which AhR can compete to regulate its expression [ 223 , 224 ]. Beta-naphthoflavone (BNF), an agonist of AhR, can disrupt several genes involved in the neuroendocrine regulation of stress [ 225 , 226 ]. Overall, most studies have shown AhR to affect the HPG axis, while the effects on GH, TSH, and ACTH are still not clear [ 227 , 228 , 229 , 230 ].…”

Section: Xenobiotics Modulating Aryl Hydrocarbon Receptor To Regulate...mentioning

confidence: 99%

“…Many exogenous AhR ligands such as TCDD and PAHs can cross the blood brain barrier (BBB) to mediate AhR action in the brain. Likewise, many endogenous AhR ligands derived from tryptophan metabolites such as indoxyl-3-sulfate (I3S), indole-3-carbinol (I3C) and FICZ also cross the BBB via gut–brain axis to modulate AhR activity in the brain in response to various environmental and metabolic cues [ 226 , 235 ]. Their ubiquitous distribution, lipid solubility and long-lasting half-life, promote bioaccumulation of the compounds throughout the food chain by depositing in lipid-heavy tissues such as adipose and brain [ 236 , 237 , 238 ].…”

Section: Xenobiotics Modulating Aryl Hydrocarbon Receptor To Regulate...mentioning

confidence: 99%

Sexual Dimorphism in Adipose-Hypothalamic Crosstalk and the Contribution of Aryl Hydrocarbon Receptor to Regulate Energy Homeostasis

Haque

Tischkau

2022

IJMS

Self Cite

View full text Add to dashboard Cite

There are fundamental sex differences in the regulation of energy homeostasis. Better understanding of the underlying mechanisms of energy balance that account for this asymmetry will assist in developing sex-specific therapies for sexually dimorphic diseases such as obesity. Multiple organs, including the hypothalamus and adipose tissue, play vital roles in the regulation of energy homeostasis, which are regulated differently in males and females. Various neuronal populations, particularly within the hypothalamus, such as arcuate nucleus (ARC), can sense nutrient content of the body by the help of peripheral hormones such leptin, derived from adipocytes, to regulate energy homeostasis. This review summarizes how adipose tissue crosstalk with homeostatic network control systems in the brain, which includes energy regulatory regions and the hypothalamic–pituitary axis, contribute to energy regulation in a sex-specific manner. Moreover, development of obesity is contingent upon diet and environmental factors. Substances from diet and environmental contaminants can exert insidious effects on energy metabolism, acting peripherally through the aryl hydrocarbon receptor (AhR). Developmental AhR activation can impart permanent alterations of neuronal development that can manifest a number of sex-specific physiological changes, which sometimes become evident only in adulthood. AhR is currently being investigated as a potential target for treating obesity. The consensus is that impaired function of the receptor protects from obesity in mice. AhR also modulates sex steroid receptors, and hence, one of the objectives of this review is to explain why investigating sex differences while examining this receptor is crucial. Overall, this review summarizes sex differences in the regulation of energy homeostasis imparted by the adipose–hypothalamic axis and examines how this axis can be affected by xenobiotics that signal through AhR.

show abstract

The Role of AhR in the Hallmarks of Brain Aging: Friend and Foe

Cited by 40 publications

References 144 publications

Aryl Hydrocarbon Receptor in Oxidative Stress as a Double Agent and Its Biological and Therapeutic Significance

Aryl Hydrocarbon Receptor in Oxidative Stress as a Double Agent and Its Biological and Therapeutic Significance

Relationships between plasma levels of nitrogenous metabolites and some psycho-neuro-endocrine parameters

Sexual Dimorphism in Adipose-Hypothalamic Crosstalk and the Contribution of Aryl Hydrocarbon Receptor to Regulate Energy Homeostasis

Contact Info

Product

Resources

About