The role of air pollutants in atopic dermatitis

Ahn, Kangmo

doi:10.1016/j.jaci.2014.09.023

Cited by 311 publications

(268 citation statements)

References 60 publications

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“…Air pollutants are known risk factors for asthma, but their role in AD is not well established [97]. A potentially harmful role for air pollutants has been considered due to the susceptibility of skin to their direct exposure.…”

Section: Air Pollutantsmentioning

confidence: 99%

“…Air pollutants may originate from indoor and/or outdoor environments and can interact with the skin by binding to stratum corneum, becoming metabolized or even penetrating the epidermis and entering systemic circulation through dermal capillaries [97].…”

Section: Air Pollutantsmentioning

confidence: 99%

“…Outdoor pollutants-Outdoor air pollutants originate from both natural (wildfires, volcanoes, and dust storms) and man-made sources (motor vehicles, power plants, and biomass burning) and include combustion products such as sulfur dioxide (SO 2 ), carbon monoxide (CO), and nitrogen dioxide (NO 2 ), as well as particulate matter (PM) [97]. It can be difficult to assess health effects of individual ambient pollutants, because these substances are rarely produced in isolation.…”

Section: Air Pollutantsmentioning

confidence: 99%

“…Indoor pollutants-Indoor air pollution can arise from stoves, construction materials, biological sources, and combustion products also found in outdoor air pollution [97]. A case-control study of Sweden children found that AD was associated with lower ventilation in the home, particularly in the child's bedroom, with a dose-dependent relationship observed [105].…”

Section: 52mentioning

confidence: 99%

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Environmental risk factors and their role in the management of atopic dermatitis

Kantor

Silverberg

2016

Expert Review of Clinical Immunology

278

225

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Introduction-The etiology of atopic dermatitis (AD) is multifactorial with interaction between genetics, immune and environmental factors.Areas covered-We review the role of prenatal exposures, irritants and pruritogens, pathogens, climate factors, including temperature, humidity, ultraviolet radiation, outdoor and indoor air pollutants, tobacco smoke exposure, water hardness, urban vs. rural living, diet, breastfeeding, probiotics and prebiotics on AD.Expert commentary-The increased global prevalence of AD cannot be attributed to genetics alone, suggesting that evolving environmental exposures may trigger and/or flare disease in predisposed individuals. There is a complex interplay between different environmental factors, including individual use of personal care products and exposure to climate, pollution, food and other exogenous factors. Understanding these complex risk factors is crucial to developing targeted interventions to prevent the disease in millions. Moreover, patients require counseling on optimal regimens for minimization of exposure to irritants and pruritogens and other harmful exposures.

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Section: Air Pollutantsmentioning

confidence: 99%

Section: Air Pollutantsmentioning

confidence: 99%

Section: Air Pollutantsmentioning

confidence: 99%

Section: 52mentioning

confidence: 99%

See 2 more Smart Citations

Environmental risk factors and their role in the management of atopic dermatitis

Kantor

Silverberg

2016

Expert Review of Clinical Immunology

278

225

View full text Add to dashboard Cite

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“…As a result, the redox balance is disturbed, causing oxidative stress and major damage to the skin cells. Accumulated ROSs react with the skin lipids, initiating the lipid peroxidation, due to which the permeability of the skin barrier is disrupted [15,22,26,27]. This can cause disorders in defense mechanisms against environmental toxins, allergens, pathogens, and UV radiation [28].…”

Section: Generation Of Reactive Oxygen Species (Ros)mentioning

confidence: 99%

The Impact of Pollution on Skin and Proper Efficacy Testing for Anti-Pollution Claims

et al. 2018

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Exposure to pollution can cause oxidative stress, premature ageing, inflammation, and diseases. Since most of us are exposed to pollution, protection is important. This can be achieved through skin protection or through protection with respect to food and food supplements. There is a wide range of products on the market with anti-pollution claims. However, it is important that these claims are thoroughly validated by proper efficacy testing. When skin cells are exposed to pollution factors, changes in a number of skin properties can be observed, such as lipid composition, lipid and protein oxidation, pH, sebum secretion rate, oxidative stress, inflammation markers, and collagen and elastin levels. These can be measured and used as markers to verify anti-pollution claims. In the present review, we summarize some of the most important in vitro and in vivo tests that are used to determine if an ingredient or formulation has anti-pollution efficacy.

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Wildfire Smoke Pollution, Climate Change, and Skin Disease

Kizer

2021

JAMA Dermatol

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More than 90% of the world's population lives in areas with unhealthy air, and air pollution ranks as the world's greatest environmental hazard to human health. In 2019, air pollution (outdoor and indoor) was the fourth leading risk factor for premature death worldwide, accounting for some 7 million deaths, primarily from heart disease, stroke, chronic obstructive pulmonary disease, lung cancer, and acute respiratory infections. 1 The number of air pollution-related hospitalizations is estimated to be 10 times greater than the number of deaths.Both short-and long-term exposures to air pollution are associated with untoward health effects. These adverse effects have been most extensively documented for the cardiovascular and respiratory systems. Evidence also links air pollution with increased adverse birth outcomes, metabolic conditions (eg, type 2 diabetes), infant developmental disorders, immune impairment, dementia, and various mental health conditions. Reports have shown that air pollution also harms skin health. [2][3][4][5] In this issue of JAMA Dermatology, Fadadu et al 6 provide important insights into the health outcomes of a worldwide growing source of air pollution: wildfire smoke. These authors report significantly increased use of the dermatology clinics at the University of California San Francisco for treatment of atopic dermatitis and itch during a 2-week period in November 2018, when smoke from the Camp Fire blanketed much of northern and central California. Although studies have linked air pollution from traffic and industrial sources to atopic dermatitis, 2-4,7-10 to my knowledge, this is the first study linking increased occurrence of atopic dermatitis and itch with acute wildfire smoke pollution.Fadadu et al 6 report dermatology clinic weekly visit rates for atopic dermatitis increased 49% for children and 15% for adults, compared with nonfire weeks, and itch clinic visit rates increased 82% for children and 29% for adults. These results are consistent with data reported from exposure to air pollution from other sources. [2][3][4][7][8][9][10] The health effects of air pollution depend primarily on its chemical composition, the duration of exposure, ambient environmental conditions, and pre-existing illnesses, and these harmful effects may be amplified by environmental conditions such as heat and increased UV radiation. The chemical composition of air pollution depends on its sources but generally includes varying mixtures of gases (eg, carbon monoxide, carbon dioxide, sulfur dioxide, nitrogen oxides, volatile organic compounds, and ozone), larger organic compounds (eg, polycyclic aromatic hydrocarbons), heavy metals (eg, lead, cadmium, and mercury), and particulate matter (PM). Particulate matter of varying size is the largest component of air pollution and most associated with excess morbidity and mortality.

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The role of air pollutants in atopic dermatitis

Cited by 311 publications

References 60 publications

Environmental risk factors and their role in the management of atopic dermatitis

Environmental risk factors and their role in the management of atopic dermatitis

The Impact of Pollution on Skin and Proper Efficacy Testing for Anti-Pollution Claims

Wildfire Smoke Pollution, Climate Change, and Skin Disease

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