2018
DOI: 10.1007/s00066-017-1256-0
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The role of albumin–bilirubin grade and inflammation-based index in patients with hepatocellular carcinoma treated with stereotactic body radiotherapy

Abstract: In this analysis, a higher ALBI grade as well as a higher CP were predictors of higher incidence of toxicity, whereas a lower IBI during treatment correlated with a better OS. These results should be further evaluated in prospective studies.

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Cited by 23 publications
(23 citation statements)
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“…Since then, intracranial stereotactic radiosurgery (SRS, 1 treatment session) and intracranial fractionated stereotactic radiotherapy (FSRT, 2-12 treatment sessions) have become an integral part in the treatment of single and multiple brain metastases, also in combination with immune-and targeted-therapies [8], benign tumors (e.g., meningioma, acoustic neuromas, or pituitary adenomas) [9], vascular malformations and functional disorders (e.g., trigeminal neuralgia) [10], among others. With recent advances in image guidance and motion management for organ and target movements (e.g., due to respiration), extracranial stereotactic body radiotherapy (SBRT, 1-12 treatment sessions) has also become a standard treatment option for many indications including primary lung, liver, pancreas, kidney, and prostate cancer [11][12][13], as well as oligometastases in lung, liver, bone, and abdominal localization [14][15][16]. Due to rapid technical development of this method in the past 2 decades, SBRT now allows a highly precise dose deposition in any target in the body with steep dose gradients to surrounding healthy organs.…”
Section: Radiosurgery and Stereotactic Body Radiotherapymentioning
confidence: 99%
“…Since then, intracranial stereotactic radiosurgery (SRS, 1 treatment session) and intracranial fractionated stereotactic radiotherapy (FSRT, 2-12 treatment sessions) have become an integral part in the treatment of single and multiple brain metastases, also in combination with immune-and targeted-therapies [8], benign tumors (e.g., meningioma, acoustic neuromas, or pituitary adenomas) [9], vascular malformations and functional disorders (e.g., trigeminal neuralgia) [10], among others. With recent advances in image guidance and motion management for organ and target movements (e.g., due to respiration), extracranial stereotactic body radiotherapy (SBRT, 1-12 treatment sessions) has also become a standard treatment option for many indications including primary lung, liver, pancreas, kidney, and prostate cancer [11][12][13], as well as oligometastases in lung, liver, bone, and abdominal localization [14][15][16]. Due to rapid technical development of this method in the past 2 decades, SBRT now allows a highly precise dose deposition in any target in the body with steep dose gradients to surrounding healthy organs.…”
Section: Radiosurgery and Stereotactic Body Radiotherapymentioning
confidence: 99%
“…Chronic inflammation is generally understood to play a critical role in tumor initiation and promotion [ 9 ]. Therefore, an inflammation-based index using serum c-reactive protein (CRP) and albumin values was shown to correlate with survival in patients with hepatocellular carcinoma undergoing stereotactic body radiotherapy [ 10 ]. Moreover, inflammatory reactions leading to metabolic alterations are strongly linked with muscle wasting, a key symptom of cancer cachexia [ 11 ].…”
Section: Introductionmentioning
confidence: 99%
“…When it comes to a healthy liver, 80% of the organ can be removed. Although the whole liver exhibits a low radiation tolerance, potentially leading to the serious condition of radiotherapy-induced liver disease (RILD) [43][44][45][46][47][48][49], the regenerative potential and the parallel radiobiological character of the liver allows for application of high doses to a defined volume without compromising liver function [50].…”
Section: Target Volume Definition: Automatic Segmentation Of Target Vmentioning
confidence: 99%