2021
DOI: 10.1080/10408398.2021.1911928
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The role of alcohol consumption in pathogenesis of gout

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Cited by 46 publications
(26 citation statements)
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“…Poor education and income levels are risk factors for gout because they are directly associated with socioeconomic position, which affects access to healthcare and treatment compliance ( 66 ). Drinking promotes uric acid metabolism, raises blood uric acid levels, and increases the risk of gout/HUA, which was consistent with our results ( 67 ). Aging, obesity, hypertension, and CKD are all common gout risk factors, raising the incidence of gout by affecting uric acid metabolism or excretion ( 3 ).…”
Section: Discussionsupporting
confidence: 93%
“…Poor education and income levels are risk factors for gout because they are directly associated with socioeconomic position, which affects access to healthcare and treatment compliance ( 66 ). Drinking promotes uric acid metabolism, raises blood uric acid levels, and increases the risk of gout/HUA, which was consistent with our results ( 67 ). Aging, obesity, hypertension, and CKD are all common gout risk factors, raising the incidence of gout by affecting uric acid metabolism or excretion ( 3 ).…”
Section: Discussionsupporting
confidence: 93%
“…Gout is painful inflammation of the joints caused by high uric acid levels and purine metabolism disorders [1][2][3]. As the standard of living increases, the incidence of gout increases and tends to be younger, closely related to alcohol consumption, and some patients are associated with genetic factors [4,5]. However, the continuous rise of blood uric acid will lead to the formation of tophite of different sizes when urate crystals precipitate and deposit in tissues or organs, bones, and joints, resulting in local deformity and swelling, pain, redness, ulceration, and dysfunction [6,7].…”
Section: Introductionmentioning
confidence: 99%
“…Indeed, there is an increase in blood UA in people who regularly consume alcohol, resulting in the development of gout manifested by joint inflammation, mainly in the lower extremities [ 45 ]. However, even with one-time alcohol abuse, toxic kidney damage/failure may occur, manifesting as an increase in circulating UA [ 46 ]. It should be noted that nitrogenous metabolic products (UA) are much less sensitive to autolytic degradation than other redox biomarkers, especially thiol antioxidants/enzymes and biomolecule oxidation products [ 43 , 47 ].…”
Section: Discussionmentioning
confidence: 99%