The Role of Amygdala in Patients With Euthymic Bipolar Disorder During Resting State

Li, Gaizhi; Liu, Penghong; Andari, Elissar; Zhang, Aixia; Zhang, Kerang

doi:10.3389/fpsyt.2018.00445

Cited by 44 publications

(13 citation statements)

References 42 publications

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“…Three studies using ALFF as outcome measures to investigate functional brain network alteration were selected for review. Of these, Li, Liu, et al (2018) reported decreased functional connectivity within the LIM, specifically through higher ALFF levels in the amygdala and supplementary motor area in individuals with bipolar disorder compared to the healthy controls. Liu and colleagues (2012) reported that those with depressive bipolar disorder had significantly higher ALFF in the left insula of the SAN along with other temporal regions, as well as the CBL.…”

Section: Resultsmentioning

confidence: 99%

Altered functional activity in bipolar disorder: A comprehensive review from a large‐scale network perspective

Yoon

Kim²,

Kim

et al. 2020

Brain and Behavior

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Background Growing literature continues to identify brain regions that are functionally altered in bipolar disorder. However, precise functional network correlates of bipolar disorder have yet to be determined due to inconsistent results. The overview of neurological alterations from a large‐scale network perspective may provide more comprehensive results and elucidate the neuropathology of bipolar disorder. Here, we critically review recent neuroimaging research on bipolar disorder using a network‐based approach. Methods A systematic search was conducted on studies published from 2009 through 2019 in PubMed and Google Scholar. Articles that utilized functional magnetic resonance imaging technique to examine altered functional activity of major regions belonging to a large‐scale brain network in bipolar disorder were selected. Results A total of 49 studies were reviewed. Within‐network hypoconnectivity was reported in bipolar disorder at rest among the default mode, salience, and central executive networks. In contrast, when performing a cognitive task, hyperconnectivity among the central executive network was found. Internetwork functional connectivity in the brain of bipolar disorder was greater between the salience and default mode networks, while reduced between the salience and central executive networks at rest, compared to control. Conclusion This systematic review suggests disruption in the functional activity of large‐scale brain networks at rest as well as during a task stimuli in bipolar disorder. Disrupted intra‐ and internetwork functional connectivity that are also associated with clinical symptoms suggest altered functional connectivity of and between large‐scale networks plays an important role in the pathophysiology of bipolar disorder.

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Section: Resultsmentioning

confidence: 99%

Altered functional activity in bipolar disorder: A comprehensive review from a large‐scale network perspective

Yoon

Kim²,

Kim

et al. 2020

Brain and Behavior

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“…Hypoconnectivity of the default mode network from the left posterior cingulate cortex to the bilateral mPFC and bilateral precuneus, and reduced salience connectivity of the left sgACC to the right inferior temporal gyrus in BD patients (57) was observed in unmedicated BD patients. In euthymic BD subjects compared to HCs, resting-state functional connectivity of the insula (59) and amygdala (60) to other brain regions was reported to be increased and decreased, respectively. In summary, the evidence from fMRI studies shows both hypoconnectivity (57, 58) and hyperconnectivity (56, 58, 59) pointing to complex alterations of functional resting-state networks.…”

Section: Discussionmentioning

confidence: 99%

Altered Electroencephalographic Resting-State Large-Scale Brain Network Dynamics in Euthymic Bipolar Disorder Patients

et al. 2019

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Background: Neuroimaging studies provided evidence for disrupted resting-state functional brain network activity in bipolar disorder (BD). Electroencephalographic (EEG) studies found altered temporal characteristics of functional EEG microstates during depressive episode within different affective disorders. Here we investigated whether euthymic patients with BD show deviant resting-state large-scale brain network dynamics as reflected by altered temporal characteristics of EEG microstates.Methods: We used high-density EEG to explore between-group differences in duration, coverage, and occurrence of the resting-state functional EEG microstates in 17 euthymic adults with BD in on-medication state and 17 age- and gender-matched healthy controls. Two types of anxiety, state and trait, were assessed separately with scores ranging from 20 to 80.Results: Microstate analysis revealed five microstates (A–E) in global clustering across all subjects. In patients compared to controls, we found increased occurrence and coverage of microstate A that did not significantly correlate with anxiety scores.Conclusion: Our results provide neurophysiological evidence for altered large-scale brain network dynamics in BD patients and suggest the increased presence of A microstate to be an electrophysiological trait characteristic of BD.

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“…Regions within DMN showed hyperconnectivity compared to healthy controls that were associated with enhanced emotional awareness (Das, Calhoun, & Malhi, 2014). Both hypoconnectivity and hyperconnectivity between amygdala and sensory-motor regions (e.g., supplementary motor area) has been observed ( (Brady, Margolis, Masters, Keshavan, & Öngür, 2017;Li, Liu, Andari, Zhang, & Zhang, 2018); see also (Wang et al, 2016)) which may be associated with motor and cognitive inhibition.…”

mentioning

confidence: 99%

Linking resting‐state networks and social cognition in schizophrenia and bipolar disorder

Jimenez

Riedel

Lee

et al. 2019

Human Brain Mapping

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Individuals with schizophrenia and bipolar disorder show alterations in functional neural connectivity during rest. However, resting‐state network (RSN) disruptions have not been systematically compared between the two disorders. Further, the impact of RSN disruptions on social cognition, a key determinant of functional outcome, has not been studied. Forty‐eight individuals with schizophrenia, 46 with bipolar disorder, and 48 healthy controls completed resting‐state functional magnetic resonance imaging. An atlas‐based approach was used to examine functional connectivity within nine RSNs across the cortex. RSN connectivity was assessed via nonparametric permutation testing, and associations with performance on emotion perception, mentalizing, and emotion management tasks were examined. Group differences were observed in the medial and lateral visual networks and the sensorimotor network. Individuals with schizophrenia demonstrated reduced connectivity relative to healthy controls in all three networks. Individuals with bipolar disorder demonstrated reduced connectivity relative to controls in the medial visual network and connectivity within this network was significantly positively correlated with emotion management. In healthy controls, connectivity within the medial and lateral visual networks positively correlated with mentalizing. No significant correlations were found for either visual network in schizophrenia. Results highlight the role of altered early visual processing in social cognitive deficits in both schizophrenia and bipolar disorder. However, individuals with bipolar disorder appear to compensate for disrupted visual network connectivity on social cognitive tasks, whereas those with schizophrenia do not. The current study adds clarity on the neurophysiology underlying social cognitive deficits that result in impaired functioning in serious mental illness.

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The Role of Amygdala in Patients With Euthymic Bipolar Disorder During Resting State

Cited by 44 publications

References 42 publications

Altered functional activity in bipolar disorder: A comprehensive review from a large‐scale network perspective

Altered functional activity in bipolar disorder: A comprehensive review from a large‐scale network perspective

Altered Electroencephalographic Resting-State Large-Scale Brain Network Dynamics in Euthymic Bipolar Disorder Patients

Linking resting‐state networks and social cognition in schizophrenia and bipolar disorder

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