The Role of Analytical Flexibility in Determining Mental Health Biomarkers

Bijsterbosch, Janine

doi:10.1016/j.bpsgos.2022.07.008

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Challenges and Future Directions In The Identification Of Ll...1

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2023

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“…In the search for neuroimaging biomarkers of LLD there are many different processing steps, parameter decisions, and modeling options to choose from. Recent studies in the general neuroimaging domain have started to reveal the impact of these analytical decisions on downstream results [ 82 – 84 ]. In addition to analytical decisions, recent work has highlighted the role of sampling variability as an explanation of inconsistencies in findings [ 85 ].…”

Section: Challenges and Future Directions In The Identification Of Ll...mentioning

confidence: 99%

Challenges in Identifying Individualized Brain Biomarkers of Late Life Depression

2023

Adv Geriatr Med Res

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Research into neuroimaging biomarkers for Late Life Depression (LLD) has identified neural correlates of LLD including increased white matter hyperintensities and reduced hippocampal volume. However, studies into neuroimaging biomarkers for LLD largely fail to converge. This lack of replicability is potentially due to challenges linked to construct variability, etiological heterogeneity, and experimental rigor. We discuss suggestions to help address these challenges, including improved construct standardization, increased sample sizes, multimodal approaches to parse heterogeneity, and the use of individualized analytical models.

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Section: Challenges and Future Directions In The Identification Of Ll...mentioning

confidence: 99%

Challenges in Identifying Individualized Brain Biomarkers of Late Life Depression

2023

Adv Geriatr Med Res

View full text Add to dashboard Cite

show abstract

The Role of Analytical Flexibility in Determining Mental Health Biomarkers

Cited by 1 publication

References 11 publications

Challenges in Identifying Individualized Brain Biomarkers of Late Life Depression

Challenges in Identifying Individualized Brain Biomarkers of Late Life Depression

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