The Role of Androgens and Estrogens on Healthy Aging and Longevity

Horstman, Astrid M.; Dillon, E. Lichar; Urban, Randall J.; Sheffield‐Moore, Melinda

doi:10.1093/gerona/gls068

Cited by 312 publications

(244 citation statements)

References 204 publications

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“…Our results found that the protective role of green tea and garlic against the deterioration in the oxidative stress parameters were obvious in males than females, that may be resulted from the deficiency in the estrogen in aged females after menopause which play a protective role against oxidative stress and in turn triggering a lot of health problem in females [54].…”

Section: Discussionmentioning

confidence: 68%

Protictive effects of green tea and garlic on the morphological and oxidative stress changes of hippocampus in aged male and female albino rats

El‐Sokkary¹,

Alghriany²,

Atia³

2018

J Histol Histopathol

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Objective: Green tea is an extremely popular drink and particularly rich in strong antioxidants, flavonoids. Also, garlic is important dietary and has medicinal role for centuries and possess both antioxidant and antiinflammatory action in several oxidative stress conditions. Materials and methods: Four groups of both male and female rats [young (3 months-old), aged (26 months-old), aged+green tea (200 mg/kg) and aged+garlic (100 mg/kg)] were used. Histological changes in the pyramidal cells of the hippocampus were examined. Levels of oxidized lipids (LPO), superoxide dismutase (SOD) activity and glutathione concentration (GSH) were measured in the serum. Results: Irregular, shrinked and deeply stained large and small pyramidal cells with fragmented nuclei and basophilic cytoplasm observed in the hippocampus of aged male and female rats. Green tea and garlic administration preserve these changes in the pyramidal cells in both genders. Aging increased the level of LPO, decreased the activity of SOD and the concentration of GSH of both male and female rats versus those of young ones. Again, green tea and garlic ameliorated these changes. Conclusion: our results showed that the protective role of green tea and garlic against oxidative stress parameters was more effective in males than females. Morphologically, garlic exerted preservation to the pyramidal cells of hippocampus more than green tea in both genders. This study suggests that the use of both green tea and garlic may inhibit the bodily changes related to aging.

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Section: Discussionmentioning

confidence: 68%

Protictive effects of green tea and garlic on the morphological and oxidative stress changes of hippocampus in aged male and female albino rats

El‐Sokkary¹,

Alghriany²,

Atia³

2018

J Histol Histopathol

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“…There has been recent interest regarding whether hormone replacement in select older adults might help prevent or potentially reverse these effects. The question remains as to whether this might help improve not only these physical and functional outcomes, but also overall longevity [10].…”

Section: Etiology and Effects Of Hypogonadism In Elderly Menmentioning

confidence: 99%

Late Onset Hypogonadism, Testosterone Replacement Therapy, and Sexual Health in Elderly Men

Griebling

2013

Curr Transl Geriatr Exp Gerontol Rep

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Testosterone levels tend to decline with advancing age in older men. Some develop symptomatic changes consistent with late onset hypogonadism. Alterations in hormone concentration can have negative impacts on multiple organ systems and physiological processes. This paper focuses on implications for sexual health in elderly men, including changes in libido, erectile function, and sexual performance. Associated concepts in cardiovascular health, cognition and mental health are reviewed. Changes in sexual function have been recognized as early indicators of underlying comorbidities, including cardiovascular diseases, metabolic syndrome, diabetes, depression, and frailty. New research developments on pathophysiology and hormone replacement therapy are highlighted.

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“…56 In comparison with clinically well-defined menopause, andropause symptoms would be rather subtle and seem to affect sexual functions, bone and muscle mass, body composition, and cardiovascular health and results in mood and cognitive disorders. 55 However, it is important to state that some men have a lower than normal T level without signs or symptoms. Moreover, some of these signs and/or symptoms are a normal part of aging and others can be caused by various underlying factors, including medication side effects, thyroid problems, depression, and excessive alcohol use.…”

Section: Lang Et Al Clinical Meaningfulness Of T Decline In Older Menmentioning

confidence: 99%

“…55,[69][70][71] In a cross-sectional population-based study (623 men, aged 65-88 years), Schaap et al have shown that serum levels of TT and FT were positively associated with physical performance and muscle strength. 69 Similar results were found in the most recent wave of the Massachusetts Male Aging Study (684 men aged 55-85 years) in which O'Donnell et al have measured muscle strength and physical performance.…”

Section: Muscle Mass and Strengthmentioning

confidence: 99%

“…8,10,[41][42][43][44][45][46][47][48][49] This condition places them at higher risk for adverse health outcomes and premature death. 8,28,[50][51][52][53][54][55] This review will aim to examine the uncertainty regarding the nature and the clinical importance of the age-related reduction in the T levels. Considerations will be given both to clinical symptoms, biochemical and clinical diagnostic criteria, and to the risk-to-benefit ratio of treating low T levels in older men.…”

Section: Introductionmentioning

confidence: 99%

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Testosterone Replacement Therapy in Reversing “Andropause”: What Is the Proof-of-Principle?

Lang

Samaras

2012

Rejuvenation Research

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Testosterone replacement therapy is often equated with the macho male physique and virility and is viewed by some as an antiaging tonic. The growth in testosterone's reputation and its increased use by men of all ages has seemed to outpace the scientific evidences. This review will aim to examine the uncertainty regarding the nature and the clinical importance of the age-related reduction in the testosterone levels. Considerations will be given both to clinical symptoms, biochemical and clinical diagnostic criteria, and to the risk-to-benefit ratio of reversing late-onset hypogonadism in aging and older men.

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The Role of Androgens and Estrogens on Healthy Aging and Longevity

Cited by 312 publications

References 204 publications

Protictive effects of green tea and garlic on the morphological and oxidative stress changes of hippocampus in aged male and female albino rats

Protictive effects of green tea and garlic on the morphological and oxidative stress changes of hippocampus in aged male and female albino rats

Late Onset Hypogonadism, Testosterone Replacement Therapy, and Sexual Health in Elderly Men

Testosterone Replacement Therapy in Reversing “Andropause”: What Is the Proof-of-Principle?

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