The Role of Angiogenesis in Cancer Treatment

Rajabi, Mehdi; Mousa, Shaker A.

doi:10.3390/biomedicines5020034

Cited by 513 publications

(393 citation statements)

References 95 publications

(81 reference statements)

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“…Although the use of anti-angiogenic drugs has proved to effectively inhibit tumor progression, it cannot eradicate the tumor as a stand-alone strategy. In this regard, the combination of anti-angiogenesis agents and chemotherapy or immunotherapy could provide an effective cancer treatment [124].…”

Section: Novel Anti-angiogenic Strategies For Cancer Treatmentmentioning

confidence: 99%

Tumor Angiogenesis and Anti-Angiogenic Strategies for Cancer Treatment

Teleanu

Chircov

Grumezescu

et al. 2019

JCM

370

251

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Angiogenesis is the process through which novel blood vessels are formed from pre-existing ones and it is involved in both physiological and pathological processes of the body. Furthermore, tumor angiogenesis is a crucial factor associated with tumor growth, progression, and metastasis. In this manner, there has been a great interest in the development of anti-angiogenesis strategies that could inhibit tumor vascularization. Conventional approaches comprise the administration of anti-angiogenic drugs that target and block the activity of proangiogenic factors. However, as their efficacy is still a matter of debate, novel strategies have been focusing on combining anti-angiogenic agents with chemotherapy or immunotherapy. Moreover, nanotechnology has also been investigated for the potential of nanomaterials to target and release anti-angiogenic drugs at specific sites. The aim of this paper is to review the mechanisms involved in angiogenesis and tumor vascularization and provide an overview of the recent trends in anti-angiogenic strategies for cancer therapy.

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Section: Novel Anti-angiogenic Strategies For Cancer Treatmentmentioning

confidence: 99%

Tumor Angiogenesis and Anti-Angiogenic Strategies for Cancer Treatment

Teleanu

Chircov

Grumezescu

et al. 2019

JCM

370

251

View full text Add to dashboard Cite

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“…In tumourigenesis, angiogenesis is important for the development and progression of malignant tumours [164]. The endothelial cells in growing cancer are active due to the release of cell growth and motility promoting proteins, creating a network of blood vessels to overcome its oxygen tension [165]. Vascular endothelial growth factor (VEGF) and fibroblast growth factor-2 (FGF2) are among the factors that play an important role in tumour angiogenesis [153].…”

Section: Suppression Of Migration Invasion and Angiogenesis Of Cancementioning

confidence: 99%

Honokiol: A Review of Its Anticancer Potential and Mechanisms

Ong

Lee

Tang

et al. 2019

Cancers

131

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Cancer is characterised by uncontrolled cell division and abnormal cell growth, which is largely caused by a variety of gene mutations. There are continuous efforts being made to develop effective cancer treatments as resistance to current anticancer drugs has been on the rise. Natural products represent a promising source in the search for anticancer treatments as they possess unique chemical structures and combinations of compounds that may be effective against cancer with a minimal toxicity profile or few side effects compared to standard anticancer therapy. Extensive research on natural products has shown that bioactive natural compounds target multiple cellular processes and pathways involved in cancer progression. In this review, we discuss honokiol, a plant bioactive compound that originates mainly from the Magnolia species. Various studies have proven that honokiol exerts broad-range anticancer activity in vitro and in vivo by regulating numerous signalling pathways. These include induction of G0/G1 and G2/M cell cycle arrest (via the regulation of cyclin-dependent kinase (CDK) and cyclin proteins), epithelial-mesenchymal transition inhibition via the downregulation of mesenchymal markers and upregulation of epithelial markers. Additionally, honokiol possesses the capability to supress cell migration and invasion via the downregulation of several matrix-metalloproteinases (activation of 5 AMP-activated protein kinase (AMPK) and KISS1/KISS1R signalling), inhibiting cell migration, invasion, and metastasis, as well as inducing anti-angiogenesis activity (via the down-regulation of vascular endothelial growth factor (VEGFR) and vascular endothelial growth factor (VEGF)). Combining these studies provides significant insights for the potential of honokiol to be a promising candidate natural compound for chemoprevention and treatment.

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“…28 However, chemokines can also play opposing roles; and the angiostatic chemokines CXCL4, CXCL9, CXCL10, CXCL11, and CXCL14 are known to suppress angiogenesis. 76 CXCL14 is upregulated in PC and correlated with increased Gleason scores, and overexpression of CXCL14 in LAPC4 cells led to a 43% reduction in tumor growth, thus confirming its angiostatic function. 6 In an ADT model of prostate cancer, a gene signature of CXCL3, CXCL5, CXCL6, and CXCL8 was verified as the chemokines associated with angiogenesis.…”

Section: Hypoxia and Angiogenesismentioning

confidence: 70%

Prostate Cancer

Rani

Dasgupta

Murphy

2019

The American Journal of Pathology

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Prostate cancer (PC) is a leading cause of death in men. Inflammation is one of the initiating processes whereby cells are trafficked into the tumor microenvironment by specific cytokines termed chemokines. This recruitment is complex and involves diverse leukocyte subsets with procancer and anticancer functions. Chemokines promote/abrogate proliferation of cancerous cells, block/aid apoptosis, and are instrumental/ detrimental in cancer cell migration required for metastasis. Chemokines guide the release/transport of immune cells that serve as chaperones at sites of inflammation, and after subsequent activation, they lead to an immune response. The variety of immune cells recruited at the site of tumor initiation possess unique functions, and the plethora of chemokines released by each cell derived from a progenitor cell activated under a defined set of conditions dictates its specific role in cancer progression/regression. Geographic consequences that govern the climate and endemic diseases, along with the associated evolutionary effects that at times protect populations from one disease, could lead to genetic variations that determine a role for ethnicity and race in PC risk and susceptibility. Dysregulated expression or an imbalance in the homeostatic mechanisms associated with chemokines is implicated in PC. This review discusses the role of inflammation and chemokines in PC.

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The Role of Angiogenesis in Cancer Treatment

Cited by 513 publications

References 95 publications

Tumor Angiogenesis and Anti-Angiogenic Strategies for Cancer Treatment

Tumor Angiogenesis and Anti-Angiogenic Strategies for Cancer Treatment

Honokiol: A Review of Its Anticancer Potential and Mechanisms

Prostate Cancer

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