The role of angiotensin II in cancer metastasis: Potential of renin-angiotensin system blockade as a treatment for cancer metastasis

Ishikane, Shin; Takahashi-Yanaga, Fumi

doi:10.1016/j.bcp.2018.03.008

Cited by 58 publications

(48 citation statements)

References 90 publications

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“…ACE inhibitors (suppressing Angiotensin II synthesis) or Angiotensin Receptor Blockers (ARB’s, blocking AT1R signaling) can have a therapeutic potential in this context [81] . Basic and meta-analytic studies have shown that these drugs reduce the metastatic features of tumors [99] . Further studies are needed to assess the role of ACE-2 inhibitors in the prevention and treatment of SARS-CoV-2 infections.…”

Section: Potential Biomarkers To Identify High Risk Patients and Targmentioning

confidence: 99%

SARS-CoV-2 and cancer: Are they really partners in crime?

Dam

Huizing

Mestach

et al. 2020

Cancer Treatment Reviews

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Highlights Cancer patients with COVID-19 have a higher morbidity and mortality. Particularly patients with ongoing or recent cancer treatment, metastatic solid tumors and hematological malignancies are at risk. Underlying immunosuppression, elevated cytokine levels, altered expression of the angiotensin converting enzyme (ACE-2) and TMPRSS2, and a prothrombotic status in cancer patients may fuel the effects of a SARS-CoV-2 sepsis. The gene expression level of ACE2 may be an indicator of the susceptibility to SARS-CoV-2 infection, while TMPRSS2 plays a supporting role. Better knowledge of the mechanisms involved may be a tool to identify high risk patients and to prevent severe complications by targeting the involved pathways.

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Section: Potential Biomarkers To Identify High Risk Patients and Targmentioning

confidence: 99%

SARS-CoV-2 and cancer: Are they really partners in crime?

Dam

Huizing

Mestach

et al. 2020

Cancer Treatment Reviews

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“…A panel of GBM EC-enriched genes we identified are linked through the renin-angiotensin system (RAS): angiotensin I converting enzyme (ACE), glutamyl aminopeptidase (ENPEP) and NADPH oxidase 4 (NOX4). RAS inhibitors suppress progression and lengthen survival period in several cancer types (Ishikane and Takahashi-Yanaga, 2018; Pinter and Jain, 2017), including glioma (Levin et al, 2017), where they have a broad spectrum effectiveness, and are currently being considered for inclusion in treatment protocols (Perdomo-Pantoja et al, 2018). ACE and ENPEP are central enzymes in the RAS, catalysing the conversion of angiotensin I to angiotensin II, and angiotensin II to angiotensin III, respectively.…”

Section: Discussionmentioning

confidence: 99%

A systems-based map of human brain cell-type enriched genes and malignancy-associated endothelial changes

Dusart

Hallström

Renné

et al. 2019

Preprint

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“…The literature confirms changes in selected components of the RAS in different types of tumors, including OC. The mechanisms of tumorigenesis and cancer progression associated with these changes still remain unclear [ 89 , 90 , 91 ]. It has been described that the ACE2/Ang1-7/MAS1 cascade opposes the effects of the ACE1/Ang II/AT1 receptor axis, inhibiting cancer cell proliferation, reducing the migratory potential and invasiveness, limiting the formation of new blood vessels.…”

Section: Ovarian Diseases Related To the Ace2/ang-(1-7)/mas1 Axismentioning

confidence: 99%

Involvement of ACE2/Ang-(1-7)/MAS1 Axis in the Regulation of Ovarian Function in Mammals

Domińska

2020

IJMS

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In addition to the classic, endocrine renin-angiotensin system, local renin-angiotensin system (RAS) has been documented in many tissues and organs, including the ovaries. The localization and functional activity of the two opposing axes of the system, viz. ACE1/Ang II/AT1 and ACE2/Ang-(1-7)/MAS1, differs between animal species and varied according to the stage of follicle development. It appears that the angiotensin peptides and their receptors participate in reproductive processes such as folliculogenesis, steroidogenesis, oocyte maturation, and ovulation. In addition, changes in the constituent compounds of local RAS may contribute to pathological conditions, such as polycystic ovary syndrome, ovarian hyperstimulation syndrome, and ovarian cancer. This review article examines the expression, localization, metabolism, and activity of individual elements of the ACE2/Ang-(1-7)/MAS1 axis in the ovaries of various animal species. The manuscript also presents the relationship between the secretion of gonadotropins and sex hormones and expression of Ang-(1-7) and MAS1 receptors. It also summarizes current knowledge regarding the positive and negative impact of ACE2/Ang-(1-7)/MAS1 axis on ovarian function.

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The role of angiotensin II in cancer metastasis: Potential of renin-angiotensin system blockade as a treatment for cancer metastasis

Cited by 58 publications

References 90 publications

SARS-CoV-2 and cancer: Are they really partners in crime?

SARS-CoV-2 and cancer: Are they really partners in crime?

A systems-based map of human brain cell-type enriched genes and malignancy-associated endothelial changes

Involvement of ACE2/Ang-(1-7)/MAS1 Axis in the Regulation of Ovarian Function in Mammals

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