The role of annexin A3 playing in cancers

Wu, Na; Liu, Shuqing; Guo, Chunmei; Hou, Zhijie; Sun, Ming‐Zhong

doi:10.1007/s12094-012-0928-6

Cited by 72 publications

(69 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, different members of the Annexin family proteins are either up-or downregulated in cancer tissue, so different Annexins may perform different roles in specific types of cancer (5,6). It has been demonstrated that Annexin A1 is associated with esophageal cancer and is overexpressed in laryngeal carcinoma cells; it may therefore progressively migrate from the nucleus towards the membrane during laryngeal tumorigenesis (7).…”

Section: Introductionmentioning

confidence: 99%

Annexin A2 is an independent prognostic biomarker for evaluating the malignant progression of laryngeal cancer

Luo

Xie

et al. 2017

Exp Ther Med

View full text Add to dashboard Cite

Abstract. Due to the lack of a definite diagnosis, a frequent recurrence rate and resistance to chemotherapy or radiotherapy, the clinical outcome for patients with advanced laryngeal cancer has not improved over the last decade. Annexin A2 is associated with the invasion and metastasis of cancer cells. In the present study, it was demonstrated using differential proteomics analysis that Annexin A2 is highly expressed in laryngeal carcinoma tissues and this was confirmed using immunohistochemistry, which demonstrated that the expression of Annexin A2 in laryngeal carcinoma tissues was significantly higher than in healthy adjacent tissue. In addition, its potential predictive value in the prognosis of patients with laryngeal carcinoma was evaluated. The results demonstrated that Annexin A2 expression was significantly associated with tumor size, lymph node metastasis, distant metastasis and clinical stage. In addition, higher Annexin A2 expression was associated with a poor prognosis of patients with laryngeal cancer. Thus, the results of the present study indicate that Annexin A2 expression is an independent prognostic biomarker for evaluating the malignant progression of laryngeal cancer.

show abstract

Section: Introductionmentioning

confidence: 99%

Annexin A2 is an independent prognostic biomarker for evaluating the malignant progression of laryngeal cancer

Luo

Xie

et al. 2017

Exp Ther Med

View full text Add to dashboard Cite

show abstract

“…It has been shown that disorders of Annexin expression are indirectly linked to different human diseases, such as rheumatoid arthritis, lung cancer, and diabetes [24][25]. The expression level of Annexin is closely related to the proliferation, differentiation, and invasion/migration of tumors as well as the clinical stages of tumors [12,20], and therefore has recently become a hot spot in the tumor research field. Human Annexin A3 genes are dispersed throughout the genome on chromosomes 4 q13-q22, including the two main isoforms of 33 kD and 36 kD [20].…”

Section: Discussionmentioning

confidence: 99%

“…Human Annexin A3 genes are dispersed throughout the genome on chromosomes 4 q13-q22, including the two main isoforms of 33 kD and 36 kD [20]. Many studies have shown that changes in Annexin A3 expression have an important impact on the onset, development, drug resistance, and metastasis of tumors [12][13][14][15][16][17][18]26]. The expression of Annexin A3 in carcinoma tissues is also closely associated with cancer type.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Impact of Annexin A3 expression in gastric cancer cells

Yu¹,

Y²,

Fan³

et al. 2014

neo

View full text Add to dashboard Cite

Annexin A3 participates in various biological processes, including tumorigenesis, drug resistance, and metastasis. The aim of this study was to investigate the expression of Annexin A3 in gastric cancer and its relationship with cell differentiation, migration, and invasion of gastric cancer cells. Annexin A3 expression in gastric cancer tissues was detected by quantitative real-time PCR and Western blotting. The proliferation of gastric cancer cells was measured by the MTT assay. Cell migration and invasion were determined via wound healing and transwell assays, respectively. Knock down of endogenous Annexin A3 in gastric cancer BGC823 cells was performed using siRNA technology. The expression of Annexin A3 was significantly upregulated in gastric cancer tissues, and negatively correlated with the differentiation degree. Silencing of endogenous Annexin A3 suppressed the proliferation, migration, and invasion of BGC823 cells. Additionally, the expression of p21, p27, TIMP-1, and TIMP-2 was upregulated, and the expression of PCNA, cyclin D1, MMP-1, and MMP-2 decreased in cells treated with Annexin A3-siRNA. Annexin A3 was upregulated in gastric cancer cells. Deletion of endogenous Annexin A3 significantly inhibited gastric cancer cell proliferation, migration, and invasion.

show abstract

“…It also increases the metastasis of lung adenocarcinoma and hepatocarcinoma. On the other hand, development of prostatic and renal carcinoma was observed with the down-regulation of annexin A3 [44].…”

Section: Annexin A3 and Cancermentioning

confidence: 99%

Annexin Proteins: Novel Promising Targets for Anticancer Drug Development

Bakar¹

2017

Unique Aspects of Anti-Cancer Drug Development

View full text Add to dashboard Cite

Intracellular Ca 2+ signaling and Ca 2+ homeostasis have long been an important subject area of cell biology. Several intracellular Ca 2+ binding proteins have been demonstrated until now, and among these, annexins are characterized by their ability to interact with membrane phospholipids and they form an evolutionary conserved multigene family with the members being expressed throughout animal and plant kingdoms. Annexin proteins are defined by different structural and biochemical criteria, and this multigene family has several biological features. In certain clinical conditions, the alterations on the localization or expression levels of annexin proteins are considered as the causes of pathological results and/or sequelae of disease. So, annexin proteins are indirectly linked to severe human diseases such as cardiovascular disease and cancer. Since annexin proteins are known to play roles in cancer, the researches are focused on defining the clinical significance of certain annexin proteins in cancer development and by the way anticancer treatments in the last decades. This chapter presents detailed information about annexin proteins and the studies on anticancer drug development targeting certain annexins. The studies denominate that targeting of certain annexin proteins reduces tumorigenesis and therapeutic resistance. So, annexin proteins have growing importance for anticancer drug development.

show abstract

The role of annexin A3 playing in cancers

Cited by 72 publications

References 23 publications

Annexin A2 is an independent prognostic biomarker for evaluating the malignant progression of laryngeal cancer

Annexin A2 is an independent prognostic biomarker for evaluating the malignant progression of laryngeal cancer

Impact of Annexin A3 expression in gastric cancer cells

Annexin Proteins: Novel Promising Targets for Anticancer Drug Development

Contact Info

Product

Resources

About