The role of anti-tumour necrosis factor in wound healing: A case report of refractory ulcerated necrobiosis lipoidica treated with adalimumab and review of the literature

Sandhu, Vijay Kumari; Alavi, Afsáneh

doi:10.1177/2050313x19881594

Cited by 8 publications

(10 citation statements)

References 34 publications

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“…The obtained spheres are not able to induce inflammation or present low proinflammatory potential in the case of Kan-loaded spheres. The proinflammatory TNF-α cytokine is involved in the early process of wound healing by recruiting inflammatory cells to the site of infection and stimulating macrophage phagocytic activity [ 93 , 94 ]. Therefore, stimulation of TNF-α production by P(3HB-3HV)-CS-Neo/-Kan treatment could contribute to an enhancement of the wound healing process, where increased levels of TNF-α are imperative for proper repair.…”

Section: Resultsmentioning

confidence: 99%

Composite P(3HB-3HV)-CS Spheres for Enhanced Antibiotic Efficiency

et al. 2021

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Natural-derived biopolymers are suitable candidates for developing specific and selective performance-enhanced antimicrobial formulations. Composite polymeric particles based on poly(3-hydroxybutyrate-co-3-hydroxyvalerate) and chitosan, P(3HB-3HV)-CS, are herein proposed as biocompatible and biodegradable delivery systems for bioproduced antibiotics: bacitracin (Bac), neomycin (Neo) and kanamycin (Kan). The stimuli-responsive spheres proved efficient platforms for boosting the antibiotic efficiency and antibacterial susceptibility, as evidenced against Gram-positive and Gram-negative strains. Absent or reduced proinflammatory effects were evidenced on macrophages in the case of Bac-/Neo- and Kan-loaded spheres, respectively. Moreover, these systems showed superior ability to sustain and sustain the proliferation of dermal fibroblasts, as well as to preserve their ultrastructure (membrane and cytoskeleton integrity) and to exhibit anti-oxidant activity. The antibiotic-loaded P(3HB-3HV)-CS spheres proved efficient alternatives for antibacterial strategies.

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Section: Resultsmentioning

confidence: 99%

Composite P(3HB-3HV)-CS Spheres for Enhanced Antibiotic Efficiency

et al. 2021

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“…Basoulis et al. and Sandhu et al 18,19 . demonstrated two patients who did not relapse after discontinuing biological agent therapy.…”

Section: Discussionmentioning

confidence: 98%

“…Basoulis et al and Sandhu et al18,19 demonstrated two patients who did not relapse after discontinuing biological agent therapy.Evidence for topical calcineurin inhibitors in the treatment of NL has been described in case reports since 2004 20. Our review highlights existing case reports and a single multicenter study supporting the use of calcineurin inhibitors.…”

mentioning

confidence: 99%

Treatment options for necrobiosis lipoidica: a systematic review

Nihal,

Caplan,

Rosenbach

et al. 2023

Int J Dermatology

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BackgroundNecrobiosis lipoidica (NL) is a rare, idiopathic, and recalcitrant disease of collagen degeneration for which treatment options have been poorly studied. Due to its recurring nature, risk for ulceration, and high morbidity, there is a need to understand existing treatment modalities to better inform clinical care.ObjectiveThis review aims to describe the therapeutic modalities reported in the literature for the treatment of NL.MethodsA literature search of treatments was performed by searching for publications between January 2016 and May 2022 on PubMed and Scopus. Given the limited high‐quality evidence, case reports and series were included. Only publications presenting information on both attempted treatments and outcomes were included.ResultsA total of 60 novel articles were identified (54 case reports, two case series, and four retrospective cohort studies). These studies cumulatively reported on 274 patients and covered treatments including phototherapy, topical corticosteroids, topical calcineurin inhibitors, biologics, immunosuppressants, JAK inhibitors, combination therapies, and several others. The greatest amount of evidence was found for photodynamic therapy (improvement in 72 of 80 patients), UVA‐based phototherapy (12 of 33), topical corticosteroids (21 of 46), compression therapy (15 of 20), and topical calcineurin inhibitors (11 of 17). Several newer treatments were also described, including ustekinumab and JAK inhibitors.ConclusionsThis systematic review provides a comprehensive summary of recently published treatments for NL. As the existing data comes predominantly from case reports and series, statistical conclusions are not assessed. A greater number of randomized controlled trials with standardized endpoints are necessary to compare treatment efficacy.

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“…In addition, it is important to know that GLUT-1 is also dependent on the levels of various growth factors, which increase when insulin levels are high [ 28 ]. This could also explain the efficacy of TNF-α inhibitor drugs in NL [ 29 ].…”

Section: Etiopathogenesismentioning

confidence: 99%

A Breakthrough in the Treatment of Necrobiosis Lipoidica? Update on Treatment, Etiopathogenesis, Diagnosis, and Clinical Presentation

Naumowicz,

Modzelewski,

Macko

et al. 2024

IJMS

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Necrobiosis lipoidica (NL) is a rare granulomatous disease of a not fully understood etiopathogenesis. Classically, NL is associated with insulin-dependent diabetes mellitus. The disease often fails to respond to conventional treatments and adversely affects patients’ quality of life. First-line medications are usually topical corticosteroids, but patients respond to them with varying degrees of success. Other options include tacrolimus, phototherapy, cyclosporine, fumaric acid esters, and biologics (adalimumab, etanercept, and infliximab). Our review aims to present new therapeutic approaches potentially effective in patients with refractory lesions, describe the presumed etiopathogenesis, and provide diagnostic guidance for clinicians. The review concludes that Janus kinase inhibitors and biologics such as ustekinumab and secukinumab can be used effectively in patients with recalcitrant NL. Another promising treatment option is tapinarof (an aryl hydrocarbon receptor agonist). However, studies on larger groups of patients are still needed to evaluate the effectiveness of different therapeutic options and to define consistent treatment regimens for NL. It is advisable to improve the awareness of physicians of various specialties regarding necrobiosis lipoidica as lesions diagnosed earlier usually have a better response to treatment.

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The role of anti-tumour necrosis factor in wound healing: A case report of refractory ulcerated necrobiosis lipoidica treated with adalimumab and review of the literature

Cited by 8 publications

References 34 publications

Composite P(3HB-3HV)-CS Spheres for Enhanced Antibiotic Efficiency

Composite P(3HB-3HV)-CS Spheres for Enhanced Antibiotic Efficiency

Treatment options for necrobiosis lipoidica: a systematic review

A Breakthrough in the Treatment of Necrobiosis Lipoidica? Update on Treatment, Etiopathogenesis, Diagnosis, and Clinical Presentation

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