The role of antiaggregant agents and anticoagulants in the prevention of aortic valve endocarditis: A double-cohort retrospective study

Commentary: “Käytännöllistelemälläkin”: Antiaggregants, anticoagulants, and endocarditis

“…Maybe some diseases and related therapies are too complex to address in a generalized way. The study by Theys and colleagues 5 confirms that patients with endocarditis are a very heterogeneous and complex group of individuals.…”

“…This study by Theys and colleagues 5 investigated in an unprejudiced manner the association of antiaggregants or anticoagulants with the risk of endocarditis in 2 retrospective cohorts that included 333 patients with aortic valve bioprosthesis between 2009 and 2019 and 137 patients with infected native aortic valves between 2007 and 2015. Multivariable Fine–Gray and logistic regression models were used.…”

Commentary: Infective endocarditis of the aortic valve: External influences?

“…The authors acknowledged that other factors might have impacted their findings. 4 Whether a direct relationship between antiplatelet or anticoagulation and IE exists is very much unknown, and this study may lead to us asking more questions as opposing to drawing conclusions.…”

“…In the December 2021 issue of JTCVS Open , Theys and colleagues 4 examined their experience with IE to investigate whether antiplatelet or anticoagulation agents have a protective effect for IE. The study included 2 cohorts: (1) patients who underwent aortic valve replacement with a bioprosthetic valve (AVR cohort) between 2009 through 2019 and (2) patients with IE of the native aortic valve (NVE cohort) between 2007 through 2015.…”

“…The study included 2 cohorts: (1) patients who underwent aortic valve replacement with a bioprosthetic valve (AVR cohort) between 2009 through 2019 and (2) patients with IE of the native aortic valve (NVE cohort) between 2007 through 2015. 4 Patients who received mechanical valve were excluded. The AVR cohort consisted of 333 patients, and 16 (4.8%) developed IE over the median of 3.72 years.…”