The role of antibiotic treatment in severe form of acute pancreatitis: A randomized prospective study

Hubaczova, Martina; Špičák, Julius; Antoš, F; Bartova, Ilona; Čech, Petr; Kasalický, Petr; Kostka, R; Lata, Jan; Leffler, J; Zavoral, Miroslav

doi:10.1016/s0016-5085(08)83204-0

Cited by 5 publications

(1 citation statement)

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“…The first RCTs from the 1970s were excluded because the enrolment criteria included disease that was too mild, and because ampicillin, an antibiotic that barely penetrates the pancreas, was used11–13. Three meeting abstracts were excluded because of insufficient data or because they reported more than one version of the same study31–33. Three studies were excluded because they evaluated the differences in efficacy between two antibiotics34–36.…”

Section: Resultsmentioning

confidence: 99%

Tagging of Escherichia coli proteins with new cassettes allowing in vivo systematic fluorescent and luminescent detection, and purification from physiological expression levels

et al. 2009

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We designed cassettes allowing the systematic fusion of fluorescent or luminescent proteins preceded by the calmodulin binding peptide tag to the C-terminus of Escherichia coli proteins. The chromosomal insertion, and thus physiological expression level of these fusions, permits the study of protein localization by fluorescent microscopy and protein quantification, in vivo and dynamically in diverse conditions. Furthermore, the calmodulin binding peptide tag allows standard detection, affinity purification, and co-purification experiments. These cassettes are therefore very valuable for the versatility of experiments they make available for a given strain, from biochemistry to dynamic and in vivo studies.

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Section: Resultsmentioning

confidence: 99%

Tagging of Escherichia coli proteins with new cassettes allowing in vivo systematic fluorescent and luminescent detection, and purification from physiological expression levels

et al. 2009

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Pharmacological interventions for acute pancreatitis

Moggia

Koti

Belgaumkar

et al. 2017

Cochrane Database of Systematic Reviews

105

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Very low-quality evidence suggests that none of the pharmacological treatments studied decrease short-term mortality in people with acute pancreatitis. However, the confidence intervals were wide and consistent with an increase or decrease in short-term mortality due to the interventions. We did not find consistent clinical benefits with any intervention. Because of the limitations in the prognostic scoring systems and because damage to organs may occur in acute pancreatitis before they are clinically manifest, future trials should consider including pancreatitis of all severity but power the study to measure the differences in the subgroup of people with severe acute pancreatitis. It may be difficult to power the studies based on mortality. Future trials in participants with acute pancreatitis should consider other outcomes such as complications or health-related quality of life as primary outcomes. Such trials should include health-related quality of life, costs, and return to work as outcomes and should follow patients for at least three months (preferably for at least one year).

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Prophylactic antibiotic treatment in acute necrotizing pancreatitis: Results from a meta-analysis

Cai

2008

Scandinavian Journal of Gastroenterology

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The role of antibiotic treatment in severe form of acute pancreatitis: A randomized prospective study

Cited by 5 publications

References 0 publications

Tagging of Escherichia coli proteins with new cassettes allowing in vivo systematic fluorescent and luminescent detection, and purification from physiological expression levels

Tagging of Escherichia coli proteins with new cassettes allowing in vivo systematic fluorescent and luminescent detection, and purification from physiological expression levels

Pharmacological interventions for acute pancreatitis

Prophylactic antibiotic treatment in acute necrotizing pancreatitis: Results from a meta-analysis

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