The Role of Antibodies in the Defense Against Tuberculosis

Acosta, Armando; López, Yamile Lira; Nor, Norazmi Mohd; Hernández-Pando, Rogelio; Álvarez, Nadine; Sarmiento, María E.; Glatman‐Freedman, Aharona

doi:10.5772/53950

Cited by 7 publications

(3 citation statements)

References 91 publications

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“…The role of antibodies in TB prophylaxis and therapy It was initially thought that antibodies could not reach the inside of cells and therefore intracellular bacteria [35]. However, intracellular pathogens can be found in the extracellular space, suggesting that they could potentially be targeted by antibodies [36], and in fact several studies support this [37,38]. Although the results published to date are inconsistent, the growing scientific literature supports the protective role of passive transfer of certain antibodies against TB [11].…”

Section: Antibody Response In Tb Treatment Response Monitoringmentioning

confidence: 99%

The role of antibodies in tuberculosis diagnosis, prophylaxis and therapy: a review from the ESGMYC study group

et al. 2022

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Tuberculosis (TB) is still responsible for the deaths of >1 million people yearly worldwide, and therefore its correct diagnosis is one of the key components of any TB eradication programme. However, current TB diagnostic tests have many limitations, and improved diagnostic accuracy is urgently needed. To improve the diagnostic performance of traditional serology, a combination of different Mycobacterium tuberculosis (MTB) antigens and different antibody isotypes has been suggested, with some showing promising performance for the diagnosis of active TB. Given the incomplete protection conferred by bacille Calmette–Guérin (BCG) vaccination against adult pulmonary TB, efforts to discover novel TB vaccines are ongoing. Efficacy studies from advanced TB vaccines designed to stimulate cell-mediated immunity failed to show protection, suggesting that they may not be sufficient and warranting the need for other types of immunity. The role of antibodies as tools for TB therapy, TB diagnosis and TB vaccine design is discussed. Finally, we propose that the inclusion of antibody-based TB vaccines in current clinical trials may be advisable to improve protection.

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Section: Antibody Response In Tb Treatment Response Monitoringmentioning

confidence: 99%

The role of antibodies in tuberculosis diagnosis, prophylaxis and therapy: a review from the ESGMYC study group

et al. 2022

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“…The second strategy of utilizing monoclonal antibodies for TB therapeutics in vivo came along with the success in hybridoma and phage display technology. Several mAbs have been subjected for testing against different Mtb antigen targets as described in Table 1 and have demonstrated a wide range of favorable responses including enhanced survival rate, decreased colony-forming unit and bacterial viability, induce the formation of granuloma and mucosal protection via Ig A ( 155 ). The hiccups in these studies are the specific defense mechanisms mediated by the antibodies along with the antibody’s specificity were not well defined ( 150 ).…”

Section: Antibody Therapymentioning

confidence: 99%

The COVID-19/Tuberculosis Syndemic and Potential Antibody Therapy for TB Based on the Lessons Learnt From the Pandemic

et al. 2022

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2020 will be marked in history for the dreadful implications of the COVID-19 pandemic that shook the world globally. The pandemic has reshaped the normality of life and affected mankind in the aspects of mental and physical health, financial, economy, growth, and development. The focus shift to COVID-19 has indirectly impacted an existing air-borne disease, Tuberculosis. In addition to the decrease in TB diagnosis, the emergence of the TB/COVID-19 syndemic and its serious implications (possible reactivation of latent TB post-COVID-19, aggravation of an existing active TB condition, or escalation of the severity of a COVID-19 during TB-COVID-19 coinfection), serve as primary reasons to equally prioritize TB. On a different note, the valuable lessons learnt for the COVID-19 pandemic provide useful knowledge for enhancing TB diagnostics and therapeutics. In this review, the crucial need to focus on TB amid the COVID-19 pandemic has been discussed. Besides, a general comparison between COVID-19 and TB in the aspects of pathogenesis, diagnostics, symptoms, and treatment options with importance given to antibody therapy were presented. Lastly, the lessons learnt from the COVID-19 pandemic and how it is applicable to enhance the antibody-based immunotherapy for TB have been presented.

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“…The growing consensus about the protective role of antibodies in mycobacterial infections [294][295][296][297][298] suggests the potential use of antibody formulations for the treatment of PNTM. Previous studies have demonstrated the role of humoral immune responses in the defence against mycobacteria in humans [299][300][301].…”

Section: (B) Treatmentmentioning

confidence: 99%

Pulmonary non-tuberculous mycobacterial infections: current state and future management

Chin

Sarmiento

Alvarez-Cabrera

et al. 2019

Eur J Clin Microbiol Infect Dis

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Currently, there is a trend of increasing incidence in pulmonary non-tuberculous mycobacterial infections (PNTM) together with a decrease in tuberculosis (TB) incidence, particularly in developed countries. The prevalence of PNTM in underdeveloped and developing countries remains unclear as there is still a lack of detection methods that could clearly diagnose PNTM applicable in these low-resource settings. Since non-tuberculous mycobacteria (NTM) are environmental pathogens, the vicinity favouring host-pathogen interactions is known as important predisposing factor for PNTM. The ongoing changes in world population, as well as socio-political and economic factors, are linked to the rise in the incidence of PNTM. Development is an important factor for the improvement of population well-being, but it has also been linked, in general, to detrimental environmental consequences, including the rise of emergent (usually neglected) infectious diseases, such as PNTM. The rise of neglected PNTM infections requires the expansion of the current efforts on the development of diagnostics, therapies and vaccines for mycobacterial diseases, which at present, are mainly focused on TB. This review discuss the current situation of PNTM and its predisposing factors, as well as the efforts and challenges for their control.

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The Role of Antibodies in the Defense Against Tuberculosis

Cited by 7 publications

References 91 publications

The role of antibodies in tuberculosis diagnosis, prophylaxis and therapy: a review from the ESGMYC study group

The role of antibodies in tuberculosis diagnosis, prophylaxis and therapy: a review from the ESGMYC study group

The COVID-19/Tuberculosis Syndemic and Potential Antibody Therapy for TB Based on the Lessons Learnt From the Pandemic

Pulmonary non-tuberculous mycobacterial infections: current state and future management

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