The role of antioxidant system genes in the formation of coronary heart disease clinical phenotypes

Podolskaya, A. A.; Анатольевна, Подольская Алла; Galyavich, А. S.; Сарварович, Галявич Альберт; Майкова, Е. В.; Владимировна, Майкова Евгения; Кравцова, О. А.; Александровна, Кравцова Ольга; Алимова, Ф. К.; Кашифовна, Алимова Фарида

doi:10.17816/kmj1594

Cited by 4 publications

(2 citation statements)

References 24 publications

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“…[ 38 , 39 ]), the accumulation of cholesterol by macrophages ( IL7R , IL7 , TIGIT , IL-8 , F2RL1 , EIF2AK3 , TSPYL2 , ANXA1 , DUSP1 и IL15 [ 40 ]), and the accumulation of the protein MMP12 (SNP next to the gene MMP12 on the chromosome 11q22.3) [ 41 ] on the body’s antioxidant defense system ( SOD , CAT , GPX1 , etc. [ 42 ]) and cholesterol metabolism ( ABCA1 , ABCG1 , APOA , APOB , APOE , CETP , LIPC , etc. ), etc.…”

Section: Resultsmentioning

confidence: 99%

Tackling Atherosclerosis via Selected Nutrition

Vesnina

Prosekov

Atuchin

et al. 2022

IJMS

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The development and pathogenesis of atherosclerosis are significantly influenced by lifestyle, particularly nutrition. The modern level of science and technology development promote personalized nutrition as an efficient preventive measure against atherosclerosis. In this survey, the factors were revealed that contribute to the formation of an individual approach to nutrition: genetic characteristics, the state of the microbiota of the gastrointestinal tract (GIT) and environmental factors (diets, bioactive components, cardioprotectors, etc.). In the course of the work, it was found that in order to analyze the predisposition to atherosclerosis associated with nutrition, genetic features affecting the metabolism of nutrients are significant. The genetic features include the presence of single nucleotide polymorphisms (SNP) of genes and epigenetic factors. The influence of telomere length on the pathogenesis of atherosclerosis and circadian rhythms was also considered. Relatively new is the study of the relationship between chrono-nutrition and the development of metabolic diseases. That is, to obtain the relationship between nutrition and atherosclerosis, a large number of genetic markers should be considered. In this relation, the question arises: “How many genetic features need to be analyzed in order to form a personalized diet for the consumer?” Basically, companies engaged in nutrigenetic research and choosing a diet for the prevention of a number of metabolic diseases use SNP analysis of genes that accounts for lipid metabolism, vitamins, the body’s antioxidant defense system, taste characteristics, etc. There is no set number of genetic markers. The main diets effective against the development of atherosclerosis were considered, and the most popular were the ketogenic, Mediterranean, and DASH-diets. The advantage of these diets is the content of foods with a low amount of carbohydrates, a high amount of vegetables, fruits and berries, as well as foods rich in antioxidants. However, due to the restrictions associated with climatic, geographical, material features, these diets are not available for a number of consumers. The way out is the use of functional products, dietary supplements. In this approach, the promising biologically active substances (BAS) that exhibit anti-atherosclerotic potential are: baicalin, resveratrol, curcumin, quercetin and other plant metabolites. Among the substances, those of animal origin are popular: squalene, coenzyme Q10, omega-3. For the prevention of atherosclerosis through personalized nutrition, it is necessary to analyze the genetic characteristics (SNP) associated with the metabolism of nutrients, to assess the state of the microbiota of the GIT. Based on the data obtained and food preferences, as well as the individual capabilities of the consumer, the optimal diet can be selected. It is topical to exclude nutrients of which their excess consumption stimulates the occurrence and pathogenesis of atherosclerosis and to enrich the diet with functional foods (FF), BAS containing the necessary anti-atherosclerotic, and stimulating microbiota of the GIT nutrients. Personalized nutrition is a topical preventive measure and there are a number of problems hindering the active use of this approach among consumers. The key factors include weak evidence of the influence of a number of genetic features, the high cost of the approach, and difficulties in the interpretation of the results. Eliminating these deficiencies will contribute to the maintenance of a healthy state of the population through nutrition.

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Section: Resultsmentioning

confidence: 99%

Tackling Atherosclerosis via Selected Nutrition

Vesnina

Prosekov

Atuchin

et al. 2022

IJMS

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“…C47T polymorphism leads to replacement of alanine (Ala) by valine (Val) amino acid, modifies secondary protein structure, alters mitochondrial targeting sequence and can affect the enzyme transfer from the cytoplasm to the mitochondrial matrix. It was found out that the enzyme activity in mitochondria is decreased by 30-40 % and the risk of developing cardiovascular pathology is elevated in T allele carriers [7].…”

Section: Resultsmentioning

confidence: 99%

Single-nucleotide Polymorphisms of AGT, SOD2, CAT in Risk Estimates for Arterial Hypertension among Young People

et al. 2019

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Arterial hypertension is one of the most common cardiovascular diseases and one of the main causes of mortality and disability of population. Opportunity to predict emergence of arterial hypertension and to take preventive measures in pre-nosological diagnostics of disease arouse research interest in this issue. Possibility to predict progression of arterial hypertension based on polymorphic variants of AGT gene (C521T, rs4762) identification, which encodes angiotensinogen protein in combination with polymorphic variants of CAT (–262C/T, rs1001179), encoding catalase, and polymorphic variants of SOD2 (C47T, rs4880), encoding mitochondrial superoxide dismutase, are discussed in this article. Decrease of antioxidant enzymes (catalase and superoxide dismutase) activity leads to accumulation of reactive oxygen species in cells. They may activate NF-kB transcription factor, which increases expression of individual genes involved in sodium homeostasis and in blood pressure control, including angiotensinogen. Increased angiotensinogen concentration in blood constitutes a risk factor in arterial hypertension development. In our opinion, combination of polymorphic variants of AGT, CAT and SOD genes expands the possibilities of personalized medicine.Performed investigation involved 65 medical students of St Petersburg State University. DNA was extracted from epithelial cells of the oral cavity. Genotyping of DNA samples was determined by real-time PCR. Obtained results of our investigation enabled to reveal AGT genotypes associated with hypertension in 12 students. The article discusses combinations of TT and CT genotypes of AGT with unfavorable alleles of antioxidant enzymes.Carriers of heterozygous SOD2 genotype and homozygous CC genotype CAT are in more unfavorable conditions compared to carriers of the CC genotype SOD2 and СТ genotype CAT, as SOD2 is a key antioxidant enzyme protecting from ROS.

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Influence of Genetic Features on the Development of Atherosclerosis

Vesnina

2023

Proceedings of the 1st International Congress "The Latest Achievements of Medicine, Healthcare, and Health-Saving Technologies"

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The role of antioxidant system genes in the formation of coronary heart disease clinical phenotypes

Cited by 4 publications

References 24 publications

Tackling Atherosclerosis via Selected Nutrition

Tackling Atherosclerosis via Selected Nutrition

Single-nucleotide Polymorphisms of AGT, SOD2, CAT in Risk Estimates for Arterial Hypertension among Young People

Influence of Genetic Features on the Development of Atherosclerosis

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