The Role of Apa-I Vitamin D Receptor Gene Polymorphism in Type 2 Diabetes Mellitus

Abstract

BACKGROUND: Type 2 diabetes mellitus (T2DM) is a chronic metabolic syndrome caused by insulin secretion abnormalities, insulin action, or both. Gene polymorphism is a risk factor of T2DM. AIM: This study aims to see the role of Apa-I Vitamin D receptor gene polymorphism on T2DM. METHODS: This study was an analytic observational with a case–control approach, consisting of 70 T2DM patients and 70 healthy subjects as a control. Genotyping of the Apa-I Vitamin D receptor gene polymorphism was performed using the polymerase chain reactions-restriction fragment length polymorphisms method. The role of the Apa-I Vitamin D receptor gene polymorphism and the risk of T2DM were analyzed using the Chi-square test. RESULTS: The results showed that there was a significant association between codominant (TT genotype); dominant; recessive models of the Apa-I Vitamin D receptor gene polymorphism with the risk of T2DM (p < 0.05; odds ratio [OR] = 0.204, 95% confidence interval [CI] = 0.063–0.662; OR = 0.337, 95% CI = 0.113–1.004; OR = 0.367, 95% CI = 0.180–0.747, respectively), but not in codominant (GT genotype) and over-dominant models (p > 0.05). CONCLUSION: This study shows a role of the codominant (TT genotype); dominant; recessive models of the Apa-I Vitamin D receptor gene polymorphism on T2DM, but not in codominant (GT genotype) and over-dominant models.