The role of apelinergic system in metabolism and reproductive system in normal and pathological conditions: an overview

Mehri, Keyvan; Hamidian, Gholamreza; Oskuye, Zohreh Zavvari; Nayebirad, Sepehr; Farajdokht, Fereshteh

doi:10.3389/fendo.2023.1193150

Cited by 12 publications

(2 citation statements)

References 191 publications

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“…This study similar with other studies done by Bertrand et al, and Gao et al, [27,28] who said that apelin has useful roles in energy metabolisms through glucose uptake increasing and insulin's sensitivity, also agreement with other study who conclude that among diabetics, apelin-12 concentration is elevated [15,29] extending susceptibility to diabetes [30. 31].…”

Section: Discussionsupporting

confidence: 92%

Evaluation of TNF-α, Apelin and Visfatin in a sample of Iraqi patients with newly diagnosed Type2 Diabetes Mellitus

Abdulkareem THABIT,

RISAN,

HACHIM

2024

jrp

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Type 2 diabetes mellitus, previously referred to as "Noninsulin-dependent diabetes" or "adult-onset diabetes," accounts for 90-95 % of all diabetes. This type involves people who suffer from relative (rather than absolute) insulin deficiency and suffer from peripheral insulin resistances. The present study aimed to detect serum marker in newly diagnosed type two diabetic mellitus patients in Baghdad province through evaluation of Tumor necrosis factor alpha, Apelin and Visfatin levels. In the current study, (140) participants were recruited and grouped into: patients group (70 patients with newly diagnosed T2DM, and (70 individuals as apparently healthy control group). In the current study, age and sex matched healthy individuals were enrolled. Results showed the serum level of TNF-α, Apelin and Visfatin were estimated by the use of ELISA technique. Furthermore, the mean serum level of TNF-α, Apelin and Visfatin in T2DM patients was 366.08± 76.99 pg/ml, 96.61± 46.62 pg/ml and 9.59± 3.62ng/ml, respectively, which was higher than that of healthy subjects (175.86± 9.92pg/ml , 15.67± 1.74 pg/ml and 2.15± 0.33ng/ml, respectively) with highly significant differences (P<0.0001). Therefore, TNF-α, Visfatin and Apelin can be applies as a diagnostic biomarker and as useful tools for predict ion and prevention of pre DM complications.

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Section: Discussionsupporting

confidence: 92%

Evaluation of TNF-α, Apelin and Visfatin in a sample of Iraqi patients with newly diagnosed Type2 Diabetes Mellitus

Abdulkareem THABIT,

RISAN,

HACHIM

2024

jrp

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“…APLN and APLNR are also found in the gonads, supraoptic hypothalamus, and paraventricular hypothalamus, suggesting that they are involved in the control of reproduction [72]. Considering apelin and its receptor are located in reproductive areas like the pituitary gland and hypothalamus, its role in enhancing steroid secretion by granulosa cells, as well as controlling the release of LH and FSH, is obvious [74]. The presence of APLN increases the secretion of progesterone and increases cell proliferation in bovine luteinizing granulosa cells, while it slows down meiotic progression when applied to bovine oocytes in vitro [72].…”

Section: Apelinmentioning

confidence: 99%

Adipokines and Reproduction in Ruminant Livestock

AL-Thuwaini,

Rhadi,

Kadhim

2024

RAS

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An adipose tissue is the principal storage site for fat and secretes adipokines, including leptin, adiponectin, resistin, chemerin, visfatin, and apelin. Adipokines and their receptors have been demonstrated to be present and to play a role in the reproductive systems of various livestock species. Livestock reproductive function is thought to be influenced by adipokines, or hormones derived from adipokines. These adipokines have been implicated at all levels of the reproductive axis, including the hypothalamic-pituitary axis and gonads. Adipokines can amplify reproductive activity by increasing energy levels and triggering the production of essential reproductive hormones. The development of reproductive hormones, semen, estrus behavior, ovulation, and subsequent development of the corpus luteum and seminal concentrations are all regulated by adipokines. In this way, adipokines could impact key elements like ovarian follicles, corpus luteum, Leydig cells, and spermatogenesis. Moreover, polymorphisms of adipokines genes have been identified in domestic animals with economic traits. Domestic animal production and reproduction traits are also affected by genetic variability in the adipokine genes. Therefore, this review aims to summarize adipokines and how they are known to regulate reproductive physiology, such as the production of steroid hormones, cell proliferation, oocyte maturation, and sperm development in domestic animals.

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Reciprocal Interactions Between Apelin and Noncoding RNAs in Cancer Progression

Jafarzadeh,

Naseri,

Khorramdelazad

et al. 2024

Cell Biochemistry & Function

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Apelin, a bioactive peptide that serves as an endogenous ligand for the apelin receptor (APJ), is overexpressed in various types of cancers and contributes to cancer cell proliferation, viability, migration, angiogenesis, and metastasis, as well as immune deviation. Noncoding RNAs (ncRNAs) regulate gene expression, and there is growing evidence suggesting a bidirectional crosstalk between ncRNAs (including long noncoding RNAs [lncRNAs], circular RNAs [circRNAs], and microRNAs [miRNAs]) and apelin in cancers. Certain miRNAs can directly target the apelin and inhibit its expression, thereby suppressing tumor growth. It has been indicated that miR‐224, miR‐195/miR‐195‐5p, miR‐204‐5p, miR‐631, miR‐4286, miR‐637, miR‐4493, and miR‐214‐3p target apelin mRNA and influence its expression in prostate cancer, lung cancer, esophageal cancer, chondrosarcoma, melanoma, gastric cancer, glioma, and hepatocellular carcinoma (HCC), respectively. Moreover, circ‐NOTCH1, circ‐ZNF264, and lncRNA BACE1‐AS upregulate apelin expression in gastric cancer, glioma, and HCC, respectively. On the other hand, apelin has been shown to regulate the expression of certain ncRNAs to affect tumorigenesis. It was revealed that apelin affects the expression of circ_0000004/miR‐1303, miR‐15a‐5p, and miR‐106a‐5p in osteosarcoma, lung cancer, and prostate cancer, respectively. This review explains a bidirectional interplay between ncRNAs and apelin in cancers to provide insights concerning the molecular mechanisms underlying this crosstalk and potential implications for cancer therapy.

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The role of apelinergic system in metabolism and reproductive system in normal and pathological conditions: an overview

Cited by 12 publications

References 191 publications

Evaluation of TNF-α, Apelin and Visfatin in a sample of Iraqi patients with newly diagnosed Type2 Diabetes Mellitus

Evaluation of TNF-α, Apelin and Visfatin in a sample of Iraqi patients with newly diagnosed Type2 Diabetes Mellitus

Adipokines and Reproduction in Ruminant Livestock

Reciprocal Interactions Between Apelin and Noncoding RNAs in Cancer Progression

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