2008
DOI: 10.1183/09059180.00010906
|View full text |Cite
|
Sign up to set email alerts
|

The role of apoptosis in pulmonary fibrosis

Abstract: Apoptosis has been defined as ''gene-directed cellular self-destruction'' and is an active process that is tightly regulated by a number of gene products, which promote or block cell death. Apoptotic death can be triggered by a wide variety of stimuli and, importantly, not all cells necessarily undergo apoptosis in response to the same stimulus. Abnormal regulation of apoptosis has been implicated in a wide range of diseases and approaches to modifying apoptosis represent important future therapeutic strategie… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1
1

Citation Types

1
42
0

Year Published

2010
2010
2024
2024

Publication Types

Select...
8

Relationship

0
8

Authors

Journals

citations
Cited by 50 publications
(43 citation statements)
references
References 56 publications
1
42
0
Order By: Relevance
“…Toward the end of healing, apoptosis of myofibroblasts has been observed to put a brake on active tissue remodeling (42,43). When activated cells fail to undergo apoptosis, chronic fibrosis can occur.…”
Section: Discussionmentioning
confidence: 99%
“…Toward the end of healing, apoptosis of myofibroblasts has been observed to put a brake on active tissue remodeling (42,43). When activated cells fail to undergo apoptosis, chronic fibrosis can occur.…”
Section: Discussionmentioning
confidence: 99%
“…40,41 Hyperoxic lungs preferentially presented a sparse or homogeneous pattern, whereas bleomycin lungs more likely showed patchy clusters of apoptotic cells. Indeed, hyperoxic lungs are recognized by injury and death of more alveolar endothelial than epithelial cells, whereas the bleomycin lung produces more alveolar epithelial cell injury and death, 20,34,35,40,42 with respect to distinctive natural histories of both models. Indeed, cellular source of apoptosis and reagent accessibility may explain part of the apparent discrepancy between the relatively lower detection rate of apoptotic cells detected by the Five-1 in hyperoxic vs bleomycin lungs, compared with the similar detection rates observed using TUNEL.…”
Section: Lung Cell Apoptosismentioning
confidence: 99%
“…34 Of the numerous cells involved in ALI/ ARDS, some exhibit intense and accelerated apoptosis (eg, epithelial and endothelial cells, lymphoid cells), and others a delayed apoptosis (eg, neutrophils, mesenchymal cells). [31][32][33][34][35] Imaging cell apoptosis in tissues of living animals has been a topic in expansion over the past few years. Several studies investigated the subject by using alternative technologies such as magnetic resonance imaging 36,37 or positron emission tomography with radiolabeled annexin V. 38 However, the resolution of these devices is appropriate to determine region of interest but does not allow the detection of apoptosis at the cellular-scale level.…”
Section: Lung Cell Apoptosismentioning
confidence: 99%
See 1 more Smart Citation
“…To date there are no animal models exactly mimicking the pathological process of UIP, but bleomycin-induced lung injury and fibrosis is most relevant and has been widely used [44,45]. Both IPF and bleomycin-induced experimental pulmonary fibrosis are characterized, and possibly induced, by lung epithelial apoptosis [46,47]. There are also evidences that lung epithelial stem cells are exhausted and fail to maintain adequate repair in IPF and bleomycin-induced pulmonary fibrosis [48,49].…”
Section: Preclinical Studies Of Stem Cells In Pulmonary Fibrosismentioning
confidence: 99%