The role of apoptosis in MCLR-induced developmental toxicity in zebrafish embryos

Cyhalofop-butyl has the potential to induce developmental toxicity, oxidative stress and apoptosis in early life stage of zebrafish (Danio rerio)

“…Caspase activity has been thought to be a crucial marker in determining the progress of cell apoptosis. It has been well known that caspase-3 plays an essential role in apoptosis, mainly by catalyzing the specific cleavage of many key cellular proteins (Liu et al, 2007;Zeng et al, 2014). It is well established that pathways to caspase-3 activation either depend on or independ on mitochondrial cytochrome c release and caspase-9 function (Porter and J€ anicke, 1999).…”

“…The induction of p53 associated with environmental pollutants induced apoptosis in zebrafish has been intensely studied (Shi et al, 2008;Deng et al, 2009;C. Zeng et al, 2014).…”

Chlorpyrifos is estrogenic and alters embryonic hatching, cell proliferation and apoptosis in zebrafish

“…These apoptotic cells were only observed in higher levels of CPF treated groups (0.75 and 1.00 mg/L). Several studies have reported that Bcl-2 gene family is an important regulator in cell apoptosis [55][56][57]. There are two main kinds of genes in Bcl-2 gene family, pro-apoptotic genes (such as Bax) and anti-apoptotic genes (such as Bcl-2).…”

Mechanisms of Microcystin-induced Cytotoxicity and Apoptosis

“…and pro-apoptotic members (Bax, Bak, Bik, Bim, etc.). MCs were found to significantly induce Bax but suppress Bcl-2, leading to the release of cytochrome c (cyt c) and caspase cascade and subsequent induction of apoptosis, in various cell types of fish, frog, mouse, rat and human [136][137][138][139][140][141][142][143].…”