The Role of Apoptosis in the Pathogenic Mechanism of Critical States (Review)

Глухов, А.И.; Грызунова, Г. К.; Усай, Л. И.; Алейникова, Т. Л.; Chernikova, Natalia V.; Бурт, А. Ю.

doi:10.15360/1813-9779-2019-2-79-98

Cited by 4 publications

(6 citation statements)

References 89 publications

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“…На сегодняшний день известны такие варианты клеточной смерти, как апоптоз, некроз, некроптоз, пироптоз, ферроптоз и аутофагия [1][2][3]. Поскольку миокард обладает крайне ограниченной способностью к регенерации, механизмы регулируемой гибели клеток, включая апоптоз, являются наиболее значимыми для современных исследований из-за их Российский кардиологический журнал 2023; 28 (11) рий (КА), в т. ч. в рамках клинических особенностей течения ИБС.…”

Section: ключевые моменты Key Messagesunclassified

“…Апоптоз ГМК приводит к прогрессированию атерогенеза: способствует кальцификации, вызывает признаки медиальной дегенерации, включая атрофию, фрагментацию эластина [2,12]. Исследования in vitro продемонстрировали способность p53 дифференцированно регулировать пролиферацию и апоптоз макрофагов и ГМК [11,12]. Нами получены данные, демонстрирующие повышение концентрации p53 в сыворотке крови при увеличении выраженности атеросклеротического поражения КА (r=0,80; p<0,001), а также статистически значимо более высокие его значения в группах с МФА, рестенозами и ИМ в анамнезе (p<0,001) в сравнении с пациентами без указанных признаков.…”

Section: результатыunclassified

“…Экспериментальные исследования показали, что индуцированный ИМ апоптоз кардиомиоцитов связан с путем CHIP-p53 (от англ. carboxy-terminus of Hsc70 interacting protein -Hsp-ассоциированная Е3-убиквитин-лигаза); при подавлении р53 апоптоз миокарда и ремоделирование желудочков останавливаются [11].…”

Section: результатыunclassified

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Relationship between apoptosis markers and the severity of coronary atherosclerosis and clinical and paraclinical characteristics of patients with coronary artery disease

Zakharyan,

Fomochkina

2023

Russ J Cardiol

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Aim. To assess markers of serum apoptosis markers depending on the severity of coronary atherosclerosis, as well as to study their relationship with clinical and paraclinical characteristics of patients with coronary artery disease (CAD).Material and methods. The study included 176 people (105 men and 71 women), of which 150 were patients with an established diagnosis of CAD, 26 — healthy volunteers (control group). The patients were divided into the following groups: group 1 — with coronary atherosclerosis without stenosis (n=17); group 2 — with hemodynamically insignificant (stenosis <50%) coronary atherosclerosis (n=21); group 3 — with hemodynamically significant (stenosis >50%) coronary atherosclerosis (n=112). Group 4 was represented by healthy volunteers (n=26). Patients underwent coronary angiography using the SYNTAX score, echocardiography, extracranial artery duplex ultrasound. All subjects were studied for the serum level of apoptosis markers Bcl-2, Bax, Bcl-2/Bax, TRAIL and p53. Statistical processing was carried out using the Statistica 10.0 software. Differences were considered significant at p<0,05.Results. There was a very high correlation between the Bcl-2 (r=-0,84; p<0,001), Bax (r=0,83; p<0,001), Bcl-2/Bax (r=-0,86; p<0,001), p53 (r=0,80; p<0,001), TRAIL (r=-0,78; p<0,001) and the severity of coronary atherosclerosis. A correlation of varying strength and significance was revealed between the values of these apoptosis markers and a number of clinical and paraclinical characteristics of patients. In addition, there were significant differences (p<0,001) in Bcl-2, Bax, Bcl2/Bax, p53 and TRAIL between groups of patients with multifocal atherosclerosis, restenosis after previous revascularization and a history of myocardial infarction in comparison with patients without these signs.Conclusion. The correlations we have identified between laboratory signs of apoptosis and coronary lesions, clinical and paraclinical characteristics of patients, as well as the detected reliability of differences between groups with multifocal atherosclerosis, coronary artery restenosis and myocardial infarction in history, make it possible to consider these biomarkers as indicators of atherosclerosis severity. This can also be the basis for the development of novel treatment and diagnostic strategies.

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Section: ключевые моменты Key Messagesunclassified

Section: результатыunclassified

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Relationship between apoptosis markers and the severity of coronary atherosclerosis and clinical and paraclinical characteristics of patients with coronary artery disease

Zakharyan,

Fomochkina

2023

Russ J Cardiol

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“…В настоящее время признано, что АФК играют важную роль в регулировании общего клеточного метаболизма, включая апоптоз. Избыточное образование АФК, часто связанное с экзогенными факторами, может привести к сдвигу окислительно-восстановительного баланса в сторону прооксидантных реакций, которые вызывают окислительный стресс [9,10]. Следовательно, АФК модифицируют основные биоактивные макромолекулы, такие как ДНК, липиды и белки.…”

Section: активные формы кислорода и зависимые от них продукты перокси...unclassified

The role of some lipids and their metabolites in programmed cell death (lipoapoptosis).

Ishutina

Andrievskaya

2022

Acta biomedica scientifica

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In recent years, the understanding of the mechanisms involved in the regulation of lipoapoptosis signaling pathways has expanded considerably. However, many mechanisms of apoptosis induction by lipids as well as molecules mediating intracellular and systemic signals belonging to AOS/enzyme-dependent phospholipid metabolites are not completely clear.This review summarizes the current understanding of the mechanisms of apoptotic cell death induction by some lipid molecules. Literature search was performed in the database “PubMed”, “eLIBRARY” using key words: “apoptosis”, “lipids”, “fatty acids”, “eicosanoids”, “reactive oxygen species”.A brief characterization of the signaling pathways of apoptosis is given. The role of reactive oxygen species and their dependent products of lipid peroxidation in the regulation of the main signaling pathways of apoptosis are shown. Particular attention is paid to the product of phospholipid metabolism – 4-hydroxynonenal.Pro- and anti-apoptotic effects of some prostaglandins are demonstrated. Arguments are presented that prostaglandins of series J and D are pro-apoptotic in most cells, and this effect depends on activation of the prostanoid receptor DP2 and on reduction of AKT kinase activity. In contrast, the E-series prostaglandins and hydroxyecosatetraenoic acid act opposite to the J-series and D-series prostaglandins, reducing apoptosis by activating AKT and increasing Bcl-2 protein expression.The role of individual fatty acids involved in the initiation and transduction of pro-apoptotic and anti-apoptotic signals is assessed. It was shown that saturated fatty acids have the maximum damaging potential than their unsaturated counterparts. An in-depth understanding and deciphering of the mechanisms by which lipids and their metabolites modulate the activation of signaling pathways of programmed cell death can help to develop therapeutic strategies to prevent a number of diseases associated with impaired regulation of apoptosis.

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“…With widespread peritonitis as a result of dysfunction of the liver, kidneys, intestines, new factors of harmful effects appear. Their role is played by intermediate and final products of normal metabolism in high concentrations (lactate, urea, creatinine, bilirubin); components and effectors of regulatory systems accumulated in pathological concentrations (kallikrein-kinin, coagulation, fibrinolytic, lipid peroxidation, neurotransmitters); products of «perverted» metabolism (aldehydes, ketones, higher alcohols), substances of intestinal origin such as indole, skatol, putrescine [5,7,10].…”

Section: Introductionmentioning

confidence: 99%

Prevention of Early Postoperative Complications of Intestinal Surgery Using Immunomodulating Therapy

Tymchenko¹

2020

Khark. Surg. Sch.

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Summary. The aim of the study is to develop a method of immunocorrection, which improves the results of treatment of patients with developed peritonitis against the background of the small intestine anastomosis leakege by stopping the cascade of SIRS and MOF. Materials and methods. The work was clinical in nature, was performed in the clinic of the SI «ZIGUS NAMSU» in the period from 2016 to 2019. We examined 58 patients with various diseases of the abdominal organs complicated by peritonitis, in which sections of the small intestine were resected. The Comparison Group included patients who received traditional therapy, patients of the Main Group, the complex of drug therapy included recombinant interleukin-2, galavit and α-lipoic acid. The results of surgical treatment were evaluated according to the classification of D. Dindo, N. Demartinesta, P.-A. Clavien (2004). Statistical analysis was removed from the Statistica 6.0 software (StatSoft, Inc. 2001) and SPSS 7.5 on Apple PC. Results and Discussion. Thus, the results of the use of a comprehensive immunomodulation scheme using IL-2, galavit and α-lipoic acid in the complex treatment of patients with widespread peritonitis against the background of intestinal anastomosis failure suggest that the developed scheme has a targeted immunoregulatory effect and prevents the excess production of inflammatory mediators in the early postoperative the period of the disease, helps to eliminate the cytokine imbalance and prevents the development of secondary immune deficiency. A comparative analysis of the incidence of complications revealed that in patients of the Main Group the average number of complications per patient was 0.53, while in the Comparison Group this indicator was 1.36. Conclusions. The use of a combination of IL-2, galavit and α-lipoic acid in the complex of treatment of common peritonitis helps to reduce the level of systemic and local postoperative complications, as well as the level of postoperative mortality.

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The Role of Apoptosis in the Pathogenic Mechanism of Critical States (Review)

Cited by 4 publications

References 89 publications

Relationship between apoptosis markers and the severity of coronary atherosclerosis and clinical and paraclinical characteristics of patients with coronary artery disease

Relationship between apoptosis markers and the severity of coronary atherosclerosis and clinical and paraclinical characteristics of patients with coronary artery disease

The role of some lipids and their metabolites in programmed cell death (lipoapoptosis).

Prevention of Early Postoperative Complications of Intestinal Surgery Using Immunomodulating Therapy

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