The Role of Aripiprazole (An Anti-psychotic Drug) in the Resolution of Acute Peripheral Inflammation in Male Wistar Rats

Methanol extract of Cola nitida ameliorates inflammation and nociception in experimental animals

“…Group 1 received 10 ml/kg normal saline orally while group 2, 3, 4 received 50,100 and 200 mg/kg of Cola nitida extract respectively through oral administration. Group 5 received 100 mg/kg of aspirin orally (Adedayo et al, 2017). One hour later, 20 μl of 1% formalin was injected subcutaneously into the dorsal surface of the left hind paw of the mice in all the groups using a micro syringe.…”

“…Group 2, 3, 4 received 50, 100, 200 mg/kg of C.nitida . Group five received 100 mg/kg of aspirin (Adedayo et al, 2017). One hour after treatment, painful writhing was induced in the mice in all experimental groups by injecting 0.2 ml of 3% acetic acid solution intraperitoneally (abdominal region) and then placed in an observation chamber.…”

The neuropsychiatric manifestations of COVID-19: Interactions with psychiatric illness and pharmacological treatment

“…Antipsychotics have distinct, albeit variable preclinical effects on immune-inflammatory cascades (as shown in Table 1 ), possibly due to different animal models being used. In a carrageenan-induced inflammatory rat model, haloperidol increases the inflammatory response [ 104 ] whereas trifluoperazine [ 105 ] and aripiprazole exhibit anti-inflammatory activities [ 106 ]. The activation of NF-kB, a crucial transcription factor in inflammation, depends on the phosphorylation of IκBα by IκB kinase (IKKβ), which has been shown to be blocked by thioridazine, thereby inducing anti-inflammatory effects [ 107 ].…”