The role of astrocytes on the effects of exercise on episodic memory function

Loprinzi, PD

doi:10.1556/2060.106.2019.04

Cited by 25 publications

(37 citation statements)

References 42 publications

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“…Specifically, the hippocampi are more enriched with astrocytes than the FC [50], and it was shown that FASN is expressed by glial cells but not by neurons [51]. Physical activity can also increase the number of astrocytes [52] and induce their biochemical reprograming [53]. Thus, astrocytes are likely to contribute to metabolic adaptation to energetic stress and distinct responses induced in the hippocampi and the FC during exercise as observed in our study.…”

Section: Discussionsupporting

confidence: 57%

Physical activity reduces anxiety and regulates brain fatty acid synthesis

et al. 2020

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Physical activity impacts brain functions, but the direct mechanisms of this effect are not fully recognized or understood. Among multidimensional changes induced by physical activity, brain fatty acids (FA) appear to play an important role; however, the knowledge in this area is particularly scarce. Here we performed global metabolomics profiling of the hippocampus and the frontal cortex (FC) in a model of voluntary running in mice. Examined brain structures responded differentially to physical activity. Specifically, the markers of the tricarboxylic acid (TCA) cycle were downregulated in the FC, whereas glycolysis was enhanced in the hippocampus. Physical activity stimulated production of myristic, palmitic and stearic FA; i.e., the primary end products of de novo lipogenesis in the brain, which was accompanied by increased expression of hippocampal fatty acid synthase (FASN), suggesting stimulation of lipid synthesis. The changes in the brain fatty acid profile were associated with reduced anxiety level in the running mice. Overall, the study examines exercise-related metabolic changes in the brain and links them to behavioral outcomes.

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Section: Discussionsupporting

confidence: 57%

Physical activity reduces anxiety and regulates brain fatty acid synthesis

et al. 2020

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“…Specifically, the hippocampi are more enriched with astrocytes than the FC [50], and it was shown that FAS is expressed by glial cells but not by neurons [51]. Physical activity can also increase the number of astrocytes [52] and induce their biochemical reprograming [53]. Thus, astrocytes are likely to contribute to metabolic adaptation to energetic stress and distinct responses induced in the hippocampi and the FC during exercise as observed in our study.…”

Section: Discussionsupporting

confidence: 58%

Physical Activity Reduces Anxiety And Regulates Brain Fatty Acid Synthesis

Liśkiewicz

Przybyła

Wojakowska

et al. 2020

Preprint

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Physical activity impacts brain functions, but the direct mechanisms of this effect are not fully recognized or understood. Among multidimensional changes induced by physical activity, brain fatty acids (FA) appear to play an important role; however, the knowledge in this area is particularly scarce. Here we performed global metabolomics profiling of the hippocampus and the frontal cortex (FC) in a model of voluntary running in mice. Examined brain structures responded differentially to physical activity. Specifically, the markers of the tricarboxylic acid (TCA) cycle were downregulated in the FC, whereas glycolysis was enhanced in the hippocampus. Physical activity stimulated production of myristic, palmitic and stearic FA; i.e., the primary end products of de novo lipogenesis in the brain, which was accompanied by increased expression of hippocampal fatty acid synthase (FAS), suggesting stimulation of lipid synthesis. The changes in the brain fatty acid profile were associated with reduced anxiety level in the running mice. Overall, the study examines exercise-related metabolic changes in the brain and links them to behavioral outcomes.

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“…We have extensively demonstrated that acute exercise [1,2], particularly high-intensity exercise [3], can enhance memory function, including episodic memory [4,5] and working memory capacity [6]. Mechanisms of this effect can be found elsewhere [7,8,9,10,11], and include, for example, increased neuronal excitability in key memory-related brain structures (e.g., hippocampus) [12]. What has been considerably less investigated, however, is whether acute exercise can effectuate intentional forgetting.…”

Section: Introductionmentioning

confidence: 99%

High-Intensity Acute Exercise and Directed Forgetting on Memory Function

Pace

Loprinzi

2019

Medicina

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Background and Objectives: Despite accumulating research demonstrating that acute exercise may enhance memory function, very little research has evaluated whether acute exercise can effectuate intentional directed forgetting (DF), an adaptative strategy to facilitate subsequent memory performance. Materials and Methods: A three-arm parallel-group randomized controlled intervention was employed. Participants were randomized into one of three groups, including: (1) exercise plus DF (Ex + DF), (2) DF (directed forgetting) only (DF) and (3) R (remember) only (R). The acute bout of exercise included 15 min of high-intensity treadmill exercise. The memory assessment involved the presentation of two-word lists. After encoding the first word list, participants were either instructed to forget all of those words (DF) or to remember them. Following this, participants encoded the second word list. Results: We observed a statistically significant main effect for list F(1, 57) = 12.27, p < 0.001, η2p = 0.18, but no main effect for group F(2, 57) = 1.32, p = 0.27, η2p = 0.04, or list by group interaction, F(2, 57) = 2.89, p = 0.06, η2p = 0.09. Conclusion: This study demonstrates a directed forgetting effect in that cueing an individual to forget a previously encoded list of items facilitates memory performance on a subsequent list of items. However, we failed to demonstrate any beneficial effect of acute exercise in facilitating directed forgetting. These findings are discussed in the context of directed forgetting theories, particularly the attention inhibition mechanism, as well as the timing of the acute bout of exercise.

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The role of astrocytes on the effects of exercise on episodic memory function

Cited by 25 publications

References 42 publications

Physical activity reduces anxiety and regulates brain fatty acid synthesis

Physical activity reduces anxiety and regulates brain fatty acid synthesis

Physical Activity Reduces Anxiety And Regulates Brain Fatty Acid Synthesis

High-Intensity Acute Exercise and Directed Forgetting on Memory Function

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