The role of atrial pressure in secreting atrial natriuretic polypeptides

Matsubara, Hiroaki; Nishikawa, Mitsushige; Umeda, Yukihisa; Taniguchi, Tomomichi; Iwasaka, Toshiji; Kurimoto, Tadashi; Yamane, Yoko; Inada, Mitsuo

doi:10.1016/0002-8703(87)90662-4

Cited by 83 publications

(23 citation statements)

References 18 publications

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“…Usually, during pregnancy the circulating blood volume increases by approximately 30% (human) [15] to 80% (mouse) [14] in mammalian species, and ANP appears to be involved in the regulation of blood pressure, blood volume, and renal function. Further, alteration in atrial stretch, such as those induced by acute blood volume expansion, stimulates the secretion of ANP from the mammalian cardiac atria [19,20,35]. Therefore, several investigators have suggested that the release of ANP was accelerated by blood volume expansion and distension of the cardiac atria during pregnancy [9,25,32,33,40], and have postulated a rise in plasma ANP levels during pregnancy that would parallel the known changes in blood volume.…”

Section: Discussionmentioning

confidence: 99%

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Synthesis and Secretion of A-Type Natriuretic Peptide in the Auricular Cardiocytes during Pregnancy and Lactation in Mouse.

Mifune

Suzuki

Honda

et al. 2000

The Journal of Veterinary Medical Science

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. A-type (atrial) natriuretic peptide (ANP) levels in the auricular cardiocytes and plasma were examined by immunohistochemistry, electron microscopy, and radioimmunoassay in pregnant and lactating mice. Additionally, the cardiocyte ANP mRNA expression was measured by the polymerase chain reaction method. ANP-immunoreactivity (IR) and the number of ANP-granules in the cardiocytes on the 18th day of gestation were greater than those in virgin controls, but the plasma ANP concentration decreased on the 18th day of gestation. On the day of delivery, ANP-IR and the number of ANP-granules in the cardiocytes were decreased compared to those during the pregnancy and to those in virgin controls, and then began to increase continually until the 15th day of lactation. Plasma ANP concentration after delivery was significantly higher than that during pregnancy, and than that in virgin controls, and continued to increase until the 15th day of lactation. Cardiocyte ANP mRNA expression was highest on the day of delivery compared to that in all the other times. In conclusion, these results suggested that the circulating systems of ANP during pregnancy and lactation were regulated differentially. nonpregnant, nonlactating controls. Moreover, we have examined the ANP mRNA levels in atrial cardiocytes to determine any change in the synthesis system of ANP during these periods. MATERIALS AND METHODS Animals:The heart and blood were obtained from 10 pregnant mice of the ICR strain (Jcl: ICR, CLEA Japan, Inc., Osaka, Japan) in each group on the 10th and 18th day of gestation, and from 10 lactating mice (same strain) in each group on the day of delivery, and on the 5th, 15th and 21st day after delivery. The day of insemination was defined as 0-day of gestation, and the day of delivery was regarded as 0-day of lactating. Normal vergin mice were used as control. All animals were kept in automatically controlled rooms (temperature: 24 ± 1°C; humidity: 55 ± 5%; automatic lighting: 6:00 a.m. to 8:00 p.m.) and fed with a pellet diet CE-2 (CLEA Japan, Inc., Osaka, Japan) and water ad libitum. These animals were sacrificed under sodium pentobarbital anesthesia (50 mg/kg, i. p.) and their hearts and blood were removed. All experiments were undertaken in accordance with Guide for Animal Experimentation, Kurume University.Immunohistochemistry: The left auricular tissue blocks were fixed in Zamboni's solution for 24 hr at 4°C. After washing with 0.15 M phosphate-buffered saline (PBS) at pH 7.3, they were dehydrated, embedded in paraffin and sectioned at 5 µm. Prior to immunohistochemical staining, the deparaffinized sections were incubated in absolute A-type (atrial) natriuretic peptide (ANP) is a circulating hormone with a wide range of biological effects, including natriuresis, diuresis and vasodilation, and it may play an important role in the regulation of blood pressure and body fluid homeostasis [5,12,29]. This peptide hormone is mainly produced and stored within secretory granules in the atrial cardiocytes [5,11,[21][22][23]. Dist...

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Section: Discussionmentioning

confidence: 99%

“…This peptide hormone is mainly produced and stored within secretory granules in the atrial cardiocytes [5,11,[21][22][23]. Distension of the cardiac atria as seen during an increase in central blood volume represents an important stimulus for the release of ANP [20,35].…”

Section: Animalsmentioning

confidence: 99%

Synthesis and Secretion of A-Type Natriuretic Peptide in the Auricular Cardiocytes during Pregnancy and Lactation in Mouse.

Mifune

Suzuki

Honda

et al. 2000

The Journal of Veterinary Medical Science

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“…In a physiological manner this seems contradictory, as it is well known that the major stimulus for release of ANP is increased blood pressure and atrial stretch (Matsubara et al, 1987). Furthermore, as expected, it has been shown that hypertensive transgenic mice have a higher content of ANP in the atrial and ventricular myocardium as well as higher levels of pro-ANP in plasma (Mifune et al, 2004).…”

Section: Physiological Response After Treatmentmentioning

confidence: 91%

Receptor binding occurrence and plasma levels of natriuretic peptides in response to sympathectomy

Hansson

2005

Microsc. Res. Tech.

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In the present investigation the relationship between the sympathetic nervous system and the endocardial levels of receptor binding sites for natriuretic peptides and the plasma content of atrial natriuretic peptide were analyzed in rats. In order to destruct the cardiac sympathetic nerve terminals, chemical sympathectomy with 6-hydroxydopamine was made in parallel with intravenous measurements of blood pressure and heart frequency. By use of immunohistochemical and enzyme-linked-immunosorbent techniques the expression of tyrosine hydroxylasepositive sympathetic nerve terminals and plasma levels of pro-atrial natriuretic peptide were determined, respectively. The occurrence of receptor binding sites for natriuretic peptides was examined by in vitro receptor autoradiography. In contrast to the marked occurrence of natriuretic peptide receptor binding sites seen in the ventricular endocardium of control rats, the sympathectomized rats exhibited a decreased number of binding sites for natriuretic peptides in the endocardium of both the right and left chambers. Interestingly, this was found in parallel with a significant decrease of systolic and diastolic blood pressure and increased plasma levels of pro-atrial natriuretic peptide in the treated group of rats. These findings, together with those in previous studies, give support to an idea that one part of the blood pressure-decreasing effects, seen in patients treated with b-adrenergic blockade, might be through a reduction of the natriuretic clearance receptor C, then giving rise to increased levels of atrial natriuretic peptide. Microsc. Res. Tech. 67:90-99, 2005. V

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“…This peptide hormone is mainly produced in the cardiac atria, where it is stored within secretory granules as a large precursor (proANP), which is the major component of the granules [5,7,27]. Distension in the cardiac atria as seen with an increase in blood pressure represents an important stimulus for the release of ANP [17,25].…”

Section: Introductionmentioning

confidence: 99%

A-type Natriuretic Peptide Level in Hypertensive Transgenic Mice

et al. 2004

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A-type (atrial) natriuretic peptide (ANP) levels in heart and plasma were examined by immunohistochemistry, electron microscopy, and radioimmunoassay (RIA) in hypertensive transgenic mice (Tsukuba hypertensive mice; THM). Additionally, the ANP mRNA level in the heart was measured using real-time polymerase chain reaction (PCR) assay. The blood pressure and the ratio of heart weight to body weight in THM was significantly higher than those in the control mice (C57BL/6J). The number of ANPgranules and ANP immunoreactivity in the auricular cardiocytes were significantly lower in THM than in the control. Ultrastructurally, the ventricular cardiocytes in the THM occasionally had ANP-like granules, which were not present in the controls. Using RIA, the plasma, auricular, and ventricular ANP concentrations were significantly higher in THM than in the control, but there was no significant difference in plasma cyclic guanosine monophosphate (GMP) concentration between THM and the control. The ANP mRNA levels of the auricular and ventricular cardiocytes in the THM were siginificantly higher than those in the controls. The present study suggested that the ANP release system of the auricular cardiocytes in these transgenic mice is different from normal (control mice). Key words: A-type natriuretic peptide, hypertension, transgenic mice, cardiocyte in its etiology [21]. Several complex physiological systems affect blood pressure, including one that is mediated by the 28-amino acid A-type (atrial) natriuretic peptide (ANP) [13,21]. ANP is a circulating hormone with a wide range of biological effects, including natriuresis, diuresis and vasodilation, and it plays an important role in the regulation of blood pres-

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The role of atrial pressure in secreting atrial natriuretic polypeptides

Cited by 83 publications

References 18 publications

Synthesis and Secretion of A-Type Natriuretic Peptide in the Auricular Cardiocytes during Pregnancy and Lactation in Mouse.

Synthesis and Secretion of A-Type Natriuretic Peptide in the Auricular Cardiocytes during Pregnancy and Lactation in Mouse.

Receptor binding occurrence and plasma levels of natriuretic peptides in response to sympathectomy

A-type Natriuretic Peptide Level in Hypertensive Transgenic Mice

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