The role of autoimmunity in thromboangiitis obliterans (Buerger's disease)

Ketha, Siva S.; Cooper, Leslie T.

doi:10.1111/nyas.12048

Cited by 47 publications

(33 citation statements)

References 78 publications

(154 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Exposure to tobacco is responsible for the start and progression of TAO in more than 95% of cases. Its suspension is the only way to prevent recurrence . We describe two cases of TAO with good response to treatment despite continuing to smoke tobacco; one case was resolved successfully with bosentan and the other patient was initially treated with intravenous alprostadil and later with sildenafil for maintenance.…”

Section: Introductionmentioning

confidence: 97%

Treatment of thromboangiitis obliterans (Buerger's disease) with high-potency vasodilators

et al. 2015

View full text Add to dashboard Cite

Thromboangiitis obliterans (TAO) or Buerger's disease is a vascular inflammatory thrombotic occlusive and segmental disease affecting distal small and medium-sized arteries of the limbs. Tobacco is the main trigger factor and avoiding it is the main treatment. Frequently, it is necessary to use high-potency vasodilators, such as iloprost, bosentan, sildenafil, or alprostadil, to relieve symptoms and reduce the risk of amputation. Iloprost is the only one that has been shown to be effective in randomized clinical trials. We report the third case of TAO treated with sildenafil and a new case treated with bosentan. This condition can be diagnosed and treated by a dermatologist. We would like to highlight the excellent clinical response despite the fact that patients continued to smoke. This finding may have important therapeutic implications because early treatment may prevent amputation and can be effective even during the process of giving up smoking.

show abstract

Section: Introductionmentioning

confidence: 97%

Treatment of thromboangiitis obliterans (Buerger's disease) with high-potency vasodilators

et al. 2015

View full text Add to dashboard Cite

show abstract

“…Arteriography is the main diagnostic test and biopsy is rarely indicated. [1,7,8] These patients have a high risk of disability and amputation. [8] In a study described a risk of amputation of 11 to 23%.…”

Section: Discussionmentioning

confidence: 99%

“…[1,7,8] These patients have a high risk of disability and amputation. [8] In a study described a risk of amputation of 11 to 23%. [9] Currently, there is no specific treatment for TAO.…”

Section: Discussionmentioning

confidence: 99%

Thromboangiitis obliterans: A rare case report

Karancı

Bedel

2019

FNG & Demiroğlu Bilim Tıp Dergisi

View full text Add to dashboard Cite

Thromboangiitis obliterans (TAO) or Buerger's disease, is a progressive disease with segmental involvement in the small and medium-sized arteries and veins in the lower and upper extremities. It usually affects men less than 40 years old and is associated with tobacco as a predisposing factor. Exclusion of systemic diseases is one of the important diagnostic criteria. Early diagnosis and treatment is important because a majority patients require amputation. In this article, we report a case of a 30-year-old male diagnosed with TAO presented as pain and discoloration in his foot. This case aims to remind emergency physicians of TAO diagnosis in patients who present with pain and discoloration in the foot.Tromboanjiitis obliterans: Nadir bir olgu sunumu ÖZ Tromboanjiitis obliterans (TAO) ya da Buerger hastalığı alt ve üst ekstremitelerdeki küçük-orta boy arter ve venlerde segmental tutulum gösteren ilerleyici bir hastalıktır. Genellikle 40 yaşın altındaki erkekleri etkiler ve predispozan faktör olarak tütün kullanımı ile ilişkilidir. Sistemik hastalıkların ekarte edilmesi önemli tanı kriterlerinden biridir. Hastaların büyük bir bölümü amputasyona maruz kaldığından erken tanı ve tedavisi önemlidir. Bu yazıda ayakta ağrı ve renk değişikliği ile başvuran, TAO tanısı konulan 30 yaşında bir erkek olgu sunuldu. Bu olgu, acil hekimleri için ayakta ağrı ve renk değişikliği ile başvuran hastalarda TAO tanısını hatırlatmayı amaçlamaktadır.

show abstract

“…TAO is a non-atherosclerotic segmental vasculitis affecting the small-and medium-sized arteries and veins of the extremities and is strongly associated with smoking [169,170]. Upper limb sympathetic ablation has been successfully performed for intractable pain, ulceration or gangrene [171][172][173][174].…”

Section: Obstructive Ischaemiamentioning

confidence: 99%

Thoracic sympathectomy: a review of current indications

et al. 2015

View full text Add to dashboard Cite

Currently, thoracic sympathetic ablation is indicated mainly for primary hyperhidrosis, especially affecting the palm, and to a lesser degree, axilla and face, and for facial blushing. Despite modern pharmaceutical, endovascular and surgical treatments, sympathetic ablation has still a place in the treatment of very selected cases of angina, arrhythmias and cardiomyopathy. Thoracic sympathetic ablation is indicated in several painful conditions: the early stages of complex regional pain syndrome, erythromelalgia, and some pancreatic and other painful abdominal pathologies. Although ischaemia was historically the major indication for sympathetic ablation, its use has declined to a few selected cases of thromboangiitis obliterans (Buerger's disease), microemboli, primary Raynaud's phenomenon and Raynaud's phenomenon secondary to collagen diseases, paraneoplastic syndrome, frostbite and vibration syndrome. Thoracic sympathetic ablation for hypertension is obsolete, and direct endovascular renal sympathectomy still requires adequate clinical trials. There are rare publications of sympathetic ablation for primary phobias, but there is no scientific basis to support sympathetic surgery for any psychiatric indication.

show abstract

The role of autoimmunity in thromboangiitis obliterans (Buerger's disease)

Cited by 47 publications

References 78 publications

Treatment of thromboangiitis obliterans (Buerger's disease) with high-potency vasodilators

Treatment of thromboangiitis obliterans (Buerger's disease) with high-potency vasodilators

Thromboangiitis obliterans: A rare case report

Thoracic sympathectomy: a review of current indications

Contact Info

Product

Resources

About