The Role of Autologous Fibrin-Platelet Glue in Plastic Surgery: A Preliminary Report

Abstract

To promote wound healing, we used autologous fibrin-platelet glue in 14 patients with skin and soft tissue losses caused by recent trauma or chronic pathology. The level of improvement was scored, arbitrarily, from 0 to 4. Very favourable results (score 3-4) were seen in 11 out of 14 patients. The glue preparation is very easy, inexpensive and creates excellent and stable hemostasis. From a general point of view, we have confirmed the utility of fibrin-platelet glue in terms of reduced infections and length of hospital stay.

A review of 100 consecutive sutureless child and adult circumcisions

“…It promotes the natural clotting pathway and is reabsorbed into the system with no foreign body or fibrosis reactions. It already has widespread use in emergency departments for the closure of superficial and facial lacerations, particularly in children [5], as well as a role in the first-line management of anal fistulas [6] as well as in the fields of otorhinolaryngology [7], cardiothoracic [8] hepatic [9] and plastic surgery [10].…”

A Novel Technique Combining Platelet Gel, Skin Graft, and Fibrin Glue for Healing Recalcitrant Lower Extremity Ulcers

“…P latelet-rich plasma (PRP) or platelet releasates have been proposed as surgical adjuncts for the treatment of wound healing, [1][2][3][4] including recalcitrant, severe leg ulcers, [5][6][7][8][9] while reducing infections and length of hospital stay. 10 In most applications, PRP is mixed with thrombin before clinical application as a means of generating a platelet gel (PG) biomaterial that is applied to tissues. The scientific rationale for the clinical use of PG is that thrombinactivated platelets release numerous growth factors (GFs) from their a-granules that can modulate cell proliferation and differentiation and accelerate soft tissue repair in vivo.…”

Blood‐derived biomaterials: fibrin sealant, platelet gel and platelet fibrin glue

“…So far, PG is produced exclusively from single‐donor platelet concentrates and there is no industrial product available. Most PGs are produced for autologous use within the scope of point‐of‐care applications using blood donated by the patient a few hours or a few days prior to surgery [42,44–46]. The platelet concentrate is usually produced using specific centrifugation systems designed for the preparation of platelet‐enriched fraction from about 50 ml of the patient's blood.…”

“…This combination used as grafting material for vertical alveolar ridge augmentation with simultaneous implant placement was found to increase vertical alveolar ridge height, while allowing for an acceptable level of osseointegration [77]. PFG has also been used successfully in patients with skin and soft tissue losses caused by recent trauma or chronic pathology, reducing infections and hospital stay [45]. Application of this biomaterial in Italy has been expanded to the treatment of diabetic and pressure ulcers, post‐traumatic and plastic tissue reconstruction, cancer surgery, liver transplantation, orthopaedic and mandibular surgery and reconstructive bone surgery.…”