The role of autonomic nervous system function in hypothermia-mediated sepsis protection

Chang, Yun Ting; Wann, Shue-Ren; Tsai, Jung-Shun; Kao, Chih-Hsiang; Lee, Po‐Tsang; Huang, Neng-Chyan; Yen, Cheng-Chang; Huang, Mu-Shun; Chang, Hong‐Tai

doi:10.1016/j.ajem.2012.08.028

Cited by 12 publications

(9 citation statements)

References 32 publications

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“…The results of this study confirm the beneficial effects of TH in experimental sepsis [6]. One of the most interesting results was not only the change seen in biomarkers but also the significantly reduced mortality of those rats that underwent hypothermia.…”

supporting

confidence: 86%

“…In this issue of The American Journal of Emergency Medicine, Chang and collaborators [6], in another very elegantly done animal study, describe the autonomic response to sepsis and the effects of mild hypothermia. These authors undertook this experiment with the hypothesis that autonomic dysfunction has a major role in the cardiovascular derangements in patients with sepsis.…”

mentioning

confidence: 98%

“…In a rat model of Staphylococcus aureus sepsis, they concluded that hypothermia had a therapeutic role by reducing autonomic dysfunction. Moreover, the use of hypothermia significantly decreased mortality because no deaths were reported on those rats receiving this therapeutic modality [6].…”

mentioning

confidence: 99%

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Therapeutic hypothermia in sepsis: to use or not to use?

Acosta-Lara¹,

Varon²

2013

The American Journal of Emergency Medicine

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supporting

confidence: 86%

mentioning

confidence: 98%

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Therapeutic hypothermia in sepsis: to use or not to use?

Acosta-Lara¹,

Varon²

2013

The American Journal of Emergency Medicine

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“…Neuroprotective effects have been described in neonatal models of Gram-positive sepsis and TH [11], whereas a lack of effects has been detected in neonatal models of Gram-negative sepsis and TH [9, 10]. In contrast, prolonged survival in Gram-negative sepsis was documented in adult models of Gram-negative and Gram-positive sepsis and TH [12, 24]. …”

Section: Discussionmentioning

confidence: 99%

Outcome of Infants with Therapeutic Hypothermia after Perinatal Asphyxia and Early-Onset Sepsis

et al. 2018

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Background: Animal models suggest that neuroprotective effects of therapeutic hypothermia (TH) after perinatal asphyxia are reduced in infants with early-onset sepsis. Objectives: To assess the outcome of infants with perinatal asphyxia, neonatal encephalopathy, and TH in the presence of early-onset sepsis. Methods: In a retrospective cohort of 1,084 infants with perinatal asphyxia and TH, the outcome of 42 infants (gestational age 36.1–42.6 weeks and birth weight 2,280–5,240 g) with proven sepsis (n = 14) and probable sepsis (n = 28) was analyzed. Death, cerebral palsy, or a delayed development at 2 years was considered an adverse outcome. Results: Sepsis was caused mostly by group B streptococci (n = 17), other Gram-positive bacteria (n = 5), and Candida albicans (n = 1). Of the 42 infants, 9 (21.4%) died, and 5 (11.9%) showed impairments on follow-up. The outcome is comparable to the previously reported outcome of infants with TH without early-onset sepsis. Conclusion: A good outcome was reported in the majority of infants with perinatal asphyxia, TH, and early-onset sepsis. Cooling should not be withheld from these infants.

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“…Furthermore, the tissue showed a reduction in lung injury on histological examination. In a more recent study of rats, Chang et al (2013) found that hypothermia reduced heart rate variability and thus improved mortality depending on the degree of sepsis.…”

Section: Written By Claranne Mathiesen Msn Rn Cnrn Director Of Medmentioning

confidence: 97%

Clinical Q & A: Translating Therapeutic Temperature Management from Theory to Practice

Bader¹

2014

Therapeutic Hypothermia and Temperature Management

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The role of autonomic nervous system function in hypothermia-mediated sepsis protection

Cited by 12 publications

References 32 publications

Therapeutic hypothermia in sepsis: to use or not to use?

Therapeutic hypothermia in sepsis: to use or not to use?

Outcome of Infants with Therapeutic Hypothermia after Perinatal Asphyxia and Early-Onset Sepsis

Clinical Q & A: Translating Therapeutic Temperature Management from Theory to Practice

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