The role of B-lymphocytes and plasma cells in the pathogenesis of inflammatory bowel diseases

Abstract

Objective: To study the literature on role of B-lymphocytes and plasma cells in the pathogenesis of Crohn’s disease (CD) and ulcerative colitis (UC). Materials and methods: We analyzed 86 literature sources from the Scopus, Web of Science, Google scholar, PubMed databases, as well as those that are freely available on Google. Results. CD and UC are a serious public health problem due to their wide prevalence, objective difficulties in treatment due to the complexity of pathogenesis and the ongoing search for effective drugs. To date, the most successful methods of pathogenetic therapy are anticytokines and the use of drugs aimed at suppressing the T-cell response. Conclusion. It is shown that when using existing methods of treatment in some patients, they are not effective. The study of B-lymphocytes and plasma cells of the lamina propria of the intestinal mucosa as a possible therapeutic target in the treatment of UC and CD is relevant.