The Role of B7 Family Molecules in Maternal–Fetal Immunity

Zhao, Yongbo; Zheng, Qi-Teng; Jin, Liping

doi:10.3389/fimmu.2020.00458

Cited by 41 publications

(37 citation statements)

References 100 publications

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“…It has been suggested that elucidation of the role of SMG6 may aid in explaining the maintenance of SARS‐CoV‐2 persistence. In addition to these 12 genes, some other genes whose differential methylation sites were identified in the gene body may also play crucial roles, such as BTNL2 , which is involved in multiple inflammatory and autoimmune diseases (Zhao et al., 2020 ). Whether these DMGs, can be used as new biomarkers of SARS‐CoV‐2 infection need further study.…”

Section: Discussionmentioning

confidence: 99%

An epigenome‐wide DNA methylation study of patients with COVID‐19

Zhou

Zhang

et al. 2021

Annals of Human Genetics

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In the early 2000s, emerging SARS‐CoV‐2, which is highly pathogenic, posed a great threat to public health. During COVID‐19, epigenetic regulation is deemed to be an important part of the pathophysiology and illness severity. Using the Illumina Infinium Methylation EPIC BeadChip (850 K), we investigated genome‐wide differences in DNA methylation between healthy subjects and COVID‐19 patients with different disease severities. We conducted a combined analysis and selected 35 “marker” genes that could indicate a SARS‐CoV‐2 infection, including 12 ( ATHL1 , CHN2 , CHST15 , CPLX2 , CRHR2 , DCAKD , GNAI2 , HECW1 , HYAL1 , MIR510 , PDE11A , and SMG6 ) situated in the promoter region. The functions and pathways of differentially methylated genes were enriched in biological processes, signal transduction, and the immune system. In the “Severe versus Mild” group, differentially methylated genes, after eliminating duplicates, were used for PPI analyses. The four hub genes ( GNG7 , GNAS , PRKCZ , and PRKAG2 ) that had the highest degree of nodes were identified and among them, GNG7 and GNAS genes expressions were also downregulated in the severe group in sequencing results. Above all, the results suggest that GNG7 and GNAS may play a non‐ignorable role in the progression of COVID‐19. In conclusion, the identified key genes and related pathways in the current study can be used to study the molecular mechanisms of COVID‐19 and may provide possibilities for specific treatments.

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Section: Discussionmentioning

confidence: 99%

An epigenome‐wide DNA methylation study of patients with COVID‐19

Zhou

Zhang

et al. 2021

Annals of Human Genetics

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“…The role of co-signaling molecules at the feto-maternal interface, such as checkpoint molecules of the B7 family, has been recently highlighted. 85 The outer layer of the placenta, formed by completely differentiated syncytiotrophoblastic cells, expresses PD-L1 abundantly. As mentioned above, this molecule is unfortunately only rarely expressed in childhood cancer.…”

Section: Similarities Between Placenta and Childhood Cancermentioning

confidence: 99%

Systematic review of the immunological landscape of Wilms tumors

Palmisani

Kovar

Kager

et al. 2021

Molecular Therapy - Oncolytics

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Results of immunotherapy in childhood solid cancer have been so far, with the exception of neuroblastoma, quite disappointing. Lack of knowledge of the immune contexture of these tumors may have contributed to the failure of immunotherapies so far. Here, we systematically reviewed the literature regarding the immunology of Wilms tumor (WT), one of the most frequent pediatric solid tumors of the abdomen. In Wilms tumor patients the high cure rate of >90%, achieved by the combination of surgery and radio-chemotherapy, is at the expense of a high early and late toxicity. Moreover, treatment-resistant entities, such as diffuse anaplastic tumors or recurrent disease, still pose unsolved clinical problems. Successful immunotherapy could represent a novel and possibly less-toxic treatment option. Employing the PRISMA (Preferred Reporting Items for Systematic Review and Meta-Analysis) method of literature search, we analyzed the current knowledge of the immunological landscape of Wilms tumors in terms of tumor microenvironment, prognostic implications of single biomarkers, and immunotherapy response.

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“…Studies reported that MTHFR was an important candidate gene for sheep milk yield traits [59,60]. NPPB, BTNL2, TAP2, and WASF3 were involved in PI3K/AKT, Ca 2+ , K + , ATP, and immunity [45,[61][62][63][64][65].…”

Section: Discussionmentioning

confidence: 99%

Identification of SNPs and Candidate Genes for Milk Produce Ability in Yorkshire Pig

Shi

Liu

et al. 2021

Preprint

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Background: Sow milk produce ability is an important limiting factor impacting suboptimal growth and survival of piglets. By pig genetic improvement, the litter size has been increased, and larger litters need more suckled mammary glands, that results in increased milk from lactating sow. Hence, it has much significance to explore the sow lactation performance. The aim of this study was to estimate genetic parameters and screen single nucleotide polymorphisms (SNPs) for milk produce ability trait in 985 Yorkshire pigs by a genome-wide association study (GWAS), and to further identify the candidate genes.Results: By ASReml, we estimated the heritability of sow milk produce ability: 0.18 ± 0.07. With the Fixed and random effect model Circulating Probability Unification (FarmCPU), we performed a GWAS, and detected seven genome-wide significant SNPs, namely, Sus scrofa Chromosome (SSC) 2: ASGA0010040 (P = 7.73E-11); SSC2:MARC0029355 (P = 1.30E-08), SSC6: WU_10.2_6_65751151 (P = 1.32E-10), SSC7: MARC0058875 (P = 4.99E-09), SSC10: WU_10.2_10_49571394 (P = 6.79E-08), SSC11: M1GA0014659 (P = 1.19E-07), and SSC15: MARC0042106 (P = 1.16E-07). We performed the distribution of phenotypes corresponding to genotypes of the seven SNPs, and showed that ASGA0010040, MARC0029355, MARC0058875, WU_10.2_10_49571394, M1GA0014659, and MARC0042106 have extreme phenotypic values corresponded to the homozygous genotypes, while the intermediate values corresponded to the heterozygous genotypes. Further, we screened for flanking regions ± 200 kb nearby seven significant SNPs, and identified 30 genes. Among of them, 24 as the candidates were involved in lactose metabolism, colostrum immunity, milk protein, and milk fat by the gene ontology (GO) and kyoto encyclopedia of genes and genomes (KEGG) analysis. Through the combined analysis between 24 candidate genes and differently expressed genes (DEGs) detected in transcriptome data (GSE101983), we found 11 commons (NAV2, ANO3, MUC15, DISP3, FBXO6, CLCN6, SLA-DQB1, PSMB8, PSMB9, TAP1, and KIF5C). Further, by comparing the chromosome positions of the candidate genes with the quantitative trait locus (QTLs) previously reported, a total of 13 genes were found to be within 0.86 Mb to 93.92 Mb of the reported QTLs for sow milk yield, in which, NAV2 was found to be located with 0.86 Mb of the QTL region ssc2: 40936355.Conclusions: In conclusion, we identified seven significant SNPs located on SSC2, 6, 7, 10, 11, and 15, and proposed 24 candidate genes for milk produce ability trait in Yorkshire pig. Among of them, 11 were the key candidates. These results contribute to the identification of variants and candidate genes for sow milk produce ability.

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The Role of B7 Family Molecules in Maternal–Fetal Immunity

Cited by 41 publications

References 100 publications

An epigenome‐wide DNA methylation study of patients with COVID‐19

An epigenome‐wide DNA methylation study of patients with COVID‐19

Systematic review of the immunological landscape of Wilms tumors

Identification of SNPs and Candidate Genes for Milk Produce Ability in Yorkshire Pig

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