The role of bacteria and viruses in Behçet syndrome: Should we move towards new paradigms?

Sciascia, Savino; Arbrile, Marta; Trunfio, Mattia; Calcagno, Andrea; Radin, Massimo; Roccatello, Dario; Lembo, David; Civra, Andrea

doi:10.1016/j.autrev.2022.103237

Cited by 6 publications

(3 citation statements)

References 50 publications

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“…The etiological hypothesis of BD was first proposed by Dr. Hulusi Behcet in 1937. Many viral infections may be associated with BD, such as herpes simplex virus (HSV), hepatitis C viruses (HCV), hepatitis B viruses (HBV), Parvovirus B19, and human immunodeficiency virus (HIV), but conclusive evidence is lacking ( Sciascia et al, 2023 ). The main component of the gut virome is bacteriophage.…”

Section: Discussionmentioning

confidence: 99%

Causal relationship between gut microbiota and Behçet’s disease: a Mendelian randomization study

Li,

Chen,

Xue

et al. 2024

Front. Microbiol.

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BackgroundWhile observational epidemiological studies have suggested an association between gut microbiota and Behçet’s disease (BD), the causal relationship between the two remains uncertain.MethodsStatistical data were obtained from gut microbiome Genome-Wide Association Studies (GWAS) published by the MiBioGen consortium, and genetic variation points were screened as instrumental variables (IV). Mendelian randomization (MR) study was performed using inverse variance weighted (IVW), weighted median, MR-Egger regression, simple mode, and weighted mode methods to evaluate the causal relationship between gut microbiota (18,340 individuals) and BD (317,252 individuals). IVW was the main method of analysis. The stability and reliability of the results were verified using the leave-one-out method, heterogeneity test, and horizontal genetic pleiotropy test. Finally, a reverse MR analysis was performed to explore reverse causality.ResultsInverse variance weighted (IVW) results showed that the genus Parasutterella (OR = 0.203, 95%CI 0.055–0.747, p = 0.016), Lachnospiraceae NC2004 group (OR = 0.101, 95%CI 0.015–0.666, p = 0.017), Turicibacter (OR = 0.043, 95%CI 0.007–0.273, p = 0.001), and Erysipelatoclostridium (OR = 0.194, 95%CI 0.040–0.926, p = 0.040) were protective factors against BD, while Intestinibacter (OR = 7.589, 95%CI 1.340–42.978, p = 0.022) might be a risk factor for BD.ConclusionOur study revealed the causal relationship between gut microbiota and BD. The microbiota that related to BD may become new biomarkers; provide new potential indicators and targets for the prevention and treatment of BD.

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Section: Discussionmentioning

confidence: 99%

Causal relationship between gut microbiota and Behçet’s disease: a Mendelian randomization study

Li,

Chen,

Xue

et al. 2024

Front. Microbiol.

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“…A number of studies have suggested a relationship between the pathogenesis of BD and bacterial and/or viral infections and/or a disturbed gut microbiome composition [18][19][20][21][22][23][24].…”

Section: Aspergillosis and Behçet Diseasementioning

confidence: 99%

Secondary cutaneous aspergillosis in a child with Behçet’s disease: a case-based update

et al. 2023

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Background Invasive aspergillosis (IA) is one of the rarest opportunistic fungal infections and has increased in frequency worldwide in recent years. It is a life-threatening infection associated with high mortality rates. Invasive pulmonary aspergillosis (IPA) is the most severe form of the disease. Extrapulmonary forms can develop as a primary infection or occur as part of a disseminated infection from the lung in severely immunocompromised patients. The major limitation in the management of these infections is the challenge of early diagnosis. Case presentation Here we report a case of secondary cutaneous aspergillosis that developed from extensive pulmonary aspergillosis in a 3-year-old female who underwent immunosuppressive therapy for a diagnosed Behçet disease (BD). Aspergillus hyphae were identified on skin biopsies. Cultures grew Aspergillus fumigatus. The diagnosis of cutaneous aspergillosis enabled us to diagnose IPA, although there was no mycopathological proof of lung infection. The patient was successfully treated with voriconazole (8 mg/kg/day) and surgical debridement of the skin lesion. Conclusions Although cutaneous involvement in aspergillosis is extremely uncommon, it may be the presenting feature in some cases, allowing for an accurate and timely diagnosis of deeply infected sites. Accordingly, when evaluating skin lesions in immunocompromised individuals, especially debilitated children with underlying diseases requiring long-term immunosuppressive agents, cutaneous aspergillosis should be vigilantly considered.

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“…The etiology of BD is not well known; however, studies suggest some risk factors, such as low socioeconomic status (SES) for Behcet uveitis and neuritis and poor hygiene conditions (10)(11)(12)(13). The environment is one of the factors described in studies that play a signi cant role in BD (12,14).…”

Section: Introductionmentioning

confidence: 99%

The Relationship Between Socioeconomic Status and Behcet’s Disease Manifestations

Mirzamohammadi,

Salehi,

Hosseini

et al. 2024

Preprint

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Background Behcet’s disease (BD) is a chronic inflammatory condition mostly identified by recurrent oral aphthous ulcers and several systemic symptoms. The etiology of BD is not clear; however, some studies suggest some risk factors, such as low socioeconomic status (SES) and poor living conditions. This study aimed to determine the relationship between SES and the first manifestation of BD, the occurrence of symptoms, and the recurrence of ocular involvement. Methods In this cross-sectional study, clinical and laboratory data and socioeconomic features of 200 patients diagnosed with BD were recorded. Patients were classified into three quantiles of SES using principal component analysis (PCA) and regression model. Fisher's exact test and the chi-square test were used to measure differences among SES groups. Results The mean age of patients was 44.9 ± 12.6 years. Most of the participants (90.5%) resided in cities. Considering BD manifestations, ocular involvement recurrence mostly occurred in patients with low SES (n = 19, 42.22%) and less often with moderate SES (n = 9, 20.00%) compared to high SES (n = 17, 37.78%) (p = 0.033). Cataract involvement was more common in the low SES group (n = 31, 50.82%) compared to the moderate (n = 24, 39.34%) and high SES (n = 12, 20%) groups (p = 0.01). There were no other statistically significant differences regarding BD organ involvements or laboratory data among different SES groups. Conclusion The present evidence concludes that SES may be an important contributing factor in the course of BD. Low SES may deteriorate relapses of ocular involvement and cataracts. Whereas, moderate SES has a protective effect on relapse, and high SES protects against cataracts.

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The role of bacteria and viruses in Behçet syndrome: Should we move towards new paradigms?

Cited by 6 publications

References 50 publications

Causal relationship between gut microbiota and Behçet’s disease: a Mendelian randomization study

Causal relationship between gut microbiota and Behçet’s disease: a Mendelian randomization study

Secondary cutaneous aspergillosis in a child with Behçet’s disease: a case-based update

The Relationship Between Socioeconomic Status and Behcet’s Disease Manifestations

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