The Role of Bacterial Adherence in Otitis Media With Effusion

Shimamura, Koichiro; Shigemi, Hideo; Kurono, Yuichi; Mogi, Goro

doi:10.1001/archotol.1990.01870100037008

Cited by 30 publications

(9 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Although the present study failed to reveal the influence of P6‐specific IgA ISCs in adenoids on the incidence of HI in NS, P6‐specific IgA antibody titers in NS were significantly increased in HI‐negative subjects. These results are consistent with our previous studies that demonstrated that IgA antibodies in NS influence the colonization of HI in the nasopharynx 18,19 . Harabuchi et al 20 found that reduction of HI from the nasopharynx was associated with secretory IgA response to P6.…”

Section: Discussionsupporting

confidence: 93%

Immune responses of adenoidal lymphocytes specific to haemophilus influenzae in the nasopharynx

et al. 1998

View full text Add to dashboard Cite

show abstract

Section: Discussionsupporting

confidence: 93%

Immune responses of adenoidal lymphocytes specific to haemophilus influenzae in the nasopharynx

et al. 1998

View full text Add to dashboard Cite

show abstract

“…Furthermore, a larger number of AHS adhered to cells from the tubal ori ce of a child as compared with those of an adult. Other authors have also found different adherence patterns of OM pathogens in children and adults (19). Thus the adherence phenomena of both AHS and OM pathogens could contribute to the increased frequency of OM in children compared with adults.…”

Section: Discussionmentioning

confidence: 93%

Bacterial Adherence to Pharyngeal Cells: In Vitro Studies with Alpha-haemolytic Streptococci and Haemophilus influenzae

Tano¹,

Hellström²

2002

Acta Oto-Laryngologica

View full text Add to dashboard Cite

We examined the adherence to pharyngeal cells of alpha-haemolytic Streptococci (AHS) and Haemophilus influenzae, representing normal flora and otitis media (OM) pathogens, respectively. The bacteria were incubated with epithelial cells brushed from the tonsils, adenoid or tubal orifice of children and adults. Adherence varied among the clinical isolates of AHS and H. influenzae. AHS adhered better to epithelial cells from a child compared with those sampled from an adult. The bacteria adhered better to cells from the tubal orifice compared with those sampled from the adenoid. The selective attachment of AHS to certain cells but not to others could not be correlated to apoptotic/necrotic cells versus viable cells. Incubation of epithelial cells with an isolate of AHS with good inhibitory activity against OM pathogens showed almost no adherence of bacteria to the epithelial cells after 12 and 24 h of incubation. If, however, an isolate of AHS with weak inhibitory activity was incubated with the cells, the bacteria that were attached to the epithelial cells from the beginning showed overgrowth in the broth and increasing attachment to the cells after 12 and 24 h. Thus the inhibitory activity of AHS could also affect the adherence of potential pathogens to the mucosal surfaces. The adherence pattern may at least partially explain the difference in susceptibility to OM between children and adults.

show abstract

“…Shimamura et al showed that adherence of bacterial strains to the nasopharyngeal mucosa is significantly higher in children with OME than in healthy children. 19 One of the goals of vaccination is to prevent bacterial colonization of the nasopharynx. Vaccination may therefore be an effective way for the prevention of OME.…”

Section: Discussionmentioning

confidence: 99%

Effect of 23 Valent Pneumococcal Polysaccharide and Haemophilus influenza Conjugated Vaccines on the Clinical Course of Otitis Media With Effusion

et al. 2002

View full text Add to dashboard Cite

show abstract

The Role of Bacterial Adherence in Otitis Media With Effusion

Cited by 30 publications

References 11 publications

Immune responses of adenoidal lymphocytes specific to haemophilus influenzae in the nasopharynx

Immune responses of adenoidal lymphocytes specific to haemophilus influenzae in the nasopharynx

Bacterial Adherence to Pharyngeal Cells: In Vitro Studies with Alpha-haemolytic Streptococci and Haemophilus influenzae

Effect of 23 Valent Pneumococcal Polysaccharide and Haemophilus influenza Conjugated Vaccines on the Clinical Course of Otitis Media With Effusion

Contact Info

Product

Resources

About