The role of Bax/Bcl-2 and Nrf2-Keap-1 signaling pathways in mediating the protective effect of boric acid on acrylamide-induced acute liver injury in rats

Cengiz, Mustafa; Ayhancı, Adnan; Akkemik, Ebru; Şahin, İlknur Kulcanay; Gür, Fatma; Bayrakdar, Alpaslan; Cengiz, Betül; Musmul, Ahmet; Gür, Bahri

doi:10.1016/j.lfs.2022.120864

Cited by 14 publications

(7 citation statements)

References 43 publications

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“…Also, hepatocellular necrosis of different sizes and diffuse degenerative changes were detected in the liver parenchyma of the animals to which we administered acrylamide. In another previous study, acrylamide was documented to cause severe damage such as hepatocyte degeneration, inflammation, congestion, necrosis, and fibrosis in rat liver injury ( Cengiz et al, 2022 ).…”

Section: Discussionmentioning

confidence: 93%

Carvacrol prevents acrylamide-induced oxidative and inflammatory liver damage and dysfunction in rats

et al. 2023

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Background: Acrylamide causes hepatotoxicity with the effect of oxidative stress and inflammatory processes. Carvacrol is a monoterpenic phenol with antioxidant and anti-inflammatory properties.Aims: To determine the effects of carvacrol on oxidative liver injury induced by acrylamide administration in rats.Methods: Rats were divided into three groups of six animals each: healthy group acrylamide group (ACR), and acrylamide + carvacrol group (TACR). First, carvacrol (50 mg/kg) was administered intraperitoneally to the CACR group. One hour later, acrylamide (20 mg/kg) was given orally to the ACR and CACR groups. This procedure was performed for 30 days, after which the animals were sacrificed. The malondialdehyde (MDA) and total glutathione (tGSH) levels, total oxidant (TOS) and total antioxidant status (TAS), tumor necrosis factor-alpha (TNF-α), interleukin-1beta (IL-1β), and nuclear factor kappa b (NF-κB) were measured in the excised liver tissues. Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels were determined in blood serum samples. Liver tissues were also examined histopathologically.Results: In the ACR group, malondialdehyde, TOS, ALT, AST levels, and NF-κB, IL-1β, and TNF-α levels were found to be high, and tGSH and total antioxidant status levels were low. In addition, diffuse degenerative changes and necrosis in hepatocytes, and moderate inflammation in the portal region were detected in the liver tissues of the ACR group. While carvacrol prevented the biochemical changes induced by acrylamide, it also alleviated the damage in the histological structure.Conclusion: Carvacrol may be used for liver damage caused by acrylamide.

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Section: Discussionmentioning

confidence: 93%

Carvacrol prevents acrylamide-induced oxidative and inflammatory liver damage and dysfunction in rats

et al. 2023

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“…These results were consistent with some previous studies, which showed decreased levels of TAOC, SOD and CAT and increased levels of H 2 O 2 and MDA in rats, mice and cells under AA exposure. 47–51 Interestingly, L. reuteri supplementation led to opposite results, i.e. an increase in SOD, CAT and TAOC and a decrease in H 2 O 2 and MDA.…”

Section: Discussionmentioning

confidence: 98%

Lactobacillus reuteri JCM 1112 ameliorates chronic acrylamide-induced glucose metabolism disorder via the bile acid–TGR5–GLP-1 axis and modulates intestinal oxidative stress in mice

Yue,

Zhao,

Guo

et al. 2024

Food Funct.

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“…This protective—rather than damaging—modulatory effect of physiological BA concentrations would also help explain how it may protect against the oxidative damage induced by different chemicals (e.g., [ 51 , 52 , 53 , 54 ]) as well as how it may induce cell proliferation/inhibition with a “bell-shaped” dose response [ 12 ].…”

Section: Effects Of Boric Acid On Cancer Cells: In Vivo and In Vitro ...mentioning

confidence: 99%

Redox Mechanisms Underlying the Cytostatic Effects of Boric Acid on Cancer Cells—An Issue Still Open

et al. 2023

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Boric acid (BA) is the dominant form of boron in plasma, playing a role in different physiological mechanisms such as cell replication. Toxic effects have been reported, both for high doses of boron and its deficiency. Contrasting results were, however, reported about the cytotoxicity of pharmacological BA concentrations on cancer cells. The aim of this review is to briefly summarize the main findings in the field ranging from the proposed mechanisms of BA uptake and actions to its effects on cancer cells.

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The role of Bax/Bcl-2 and Nrf2-Keap-1 signaling pathways in mediating the protective effect of boric acid on acrylamide-induced acute liver injury in rats

Cited by 14 publications

References 43 publications

Carvacrol prevents acrylamide-induced oxidative and inflammatory liver damage and dysfunction in rats

Carvacrol prevents acrylamide-induced oxidative and inflammatory liver damage and dysfunction in rats

Lactobacillus reuteri JCM 1112 ameliorates chronic acrylamide-induced glucose metabolism disorder via the bile acid–TGR5–GLP-1 axis and modulates intestinal oxidative stress in mice

Redox Mechanisms Underlying the Cytostatic Effects of Boric Acid on Cancer Cells—An Issue Still Open

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