The Role of .BETA.2 Microglobulin Levels in Monitoring Chronic Hepatitis B

Yegane, Selma; Revanli, Melek; Taneli, Fatma

doi:10.1620/tjem.203.53

Cited by 9 publications

(11 citation statements)

References 13 publications

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“…Though they did not work on HBV/HDV coinfection, their observation was similar to the result obtained in this study as 23.7% of patients monoinfected with HBV, 29% monoinfected with HDV and 39% coinfection have 2βM level well above the acceptable serum concentration and high incidence of HDV in chronic HBV has being reported. Yeagane et al [ 17 ] then concluded that 2βM is an indicator for monitoring chronic hepatitis which is in agreement with this study as the trend of increase suggests that coinfection of HBV/HDV have influenced the increment in 2βM concentration in coinfected individuals. This result is similar to a study by Casey et al [ 18 ] where they reported 64% of individuals were coinfected with HBV and HDV and concluded that coinfection of HBV with HDV was responsible for the frequent hepatitis outbreak in a military setting.…”

Section: Main Textsupporting

confidence: 90%

“…1 ) compared with HBsAg monoinfection and HDV monoinfection. Yegane et al [ 17 ] reported the role of 2βM in monitoring chronic HBV infection where they estimated the serum 2βM level in individuals with chronic HBV infection and found that serum 2βM was higher in cases of chronic HBV as compared to controls without HBV. Though they did not work on HBV/HDV coinfection, their observation was similar to the result obtained in this study as 23.7% of patients monoinfected with HBV, 29% monoinfected with HDV and 39% coinfection have 2βM level well above the acceptable serum concentration and high incidence of HDV in chronic HBV has being reported.…”

Section: Main Textmentioning

confidence: 99%

“…In Nigeria information regarding HDV is scanty but a few have reported HDV in chronic liver diseases [ 17 ]. Due to the complications likely to be produced by HBV and HDV confection, more awareness needs to be created in Nigeria and sub-Saharan Africa.…”

Section: Introductionmentioning

confidence: 99%

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Elevated serum β2-microglobulin in individuals coinfected with hepatitis B and hepatitis D virus in a rural settings in Southwest Nigeria

Okoror

Ajayi

Ijalana³

2017

BMC Res Notes

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ObjectiveCoinfection of hepatitis B virus (HBV) with hepatitis D virus (HDV) has being reported to increase severity of progression to hepatocellular carcinoma (HCC) and liver cirrhosis (LC). Beta microglobulin (2βM) which is present on the surfaces of blood cells in acceptable levels is a tumor marker which may become elevated in disease conditions. This study hence observed the prevalence of HBV and HDV coinfection in a rural population and their 2βM concentration.ResultsOf the 368 samples, 66 (17.9%) were positive to hepatitis B surface antigen (HBsAg) and 33 (50%) were coinfected with HDV, 8 (2.1%) were monoinfected with HDV. 2βM concentration increased beyond the normal level in individuals coinfected with HBV and HDV as compared with the monoinfected individuals. Coinfection resulted in the increased concentration of 2βM in HBV and HDV coinfection and the likelihood of progression to HCC and LC may not be ruled out. Monoinfection with HDV also had high 2βM concentration but this is due to having being infected with a non-detected HBV or chronic infection in which HBV is clearing.

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Section: Main Textsupporting

confidence: 90%

Section: Main Textmentioning

confidence: 99%

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Elevated serum β2-microglobulin in individuals coinfected with hepatitis B and hepatitis D virus in a rural settings in Southwest Nigeria

Okoror

Ajayi

Ijalana³

2017

BMC Res Notes

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“…(Abdolsamadi et al, 2013). In previous studies, significant increase was observed in the β-2 MG levels both in acute viral hepatitis and in patients with chronic hepatitis (Man et al, 1989;Yegane et al, 2004;Westral et al, 1984;Malaguarnera et al, 2000). In the study by Gunbay and coworkers (2014) where they evaluated β-2 MG as a prognostic factor in the management of chronic hepatitis B, patients were divided into two groups with Group 1 comprising those who had biopsies due to the diagnosis of CHB and Group 2 including inactive HBsAg(+) carriers.…”

Section: Discussionmentioning

confidence: 85%

Prognostic value of Golgi P 73 and Beta 2-microglobulin in patients with Viral Hepatitis B

Deveci¹,

Kaplan

Tekin

et al. 2020

Acta Biochim Pol

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Previous studies detected higher Golgi protein 73 levels in the serum of patients with chronic liver disease. The Beta-2 microglobulin levels were also observed to be higher in patients with chronic hepatitis B infection compared to the inactive carriers and the protein plays an important role in the response to viral infections. The aim of the present study was to assess the liver fibrosis through non-invasive methods in chronic hepatitis B patients. Three groups were included in the study. The first group comprised of the patients who were admitted to the Infectious Diseases and Clinical Microbiology clinic to undergo a liver biopsy, while the second group included the patients who were admitted inactive hepatitis B carriers. The third group comprised the healthy controls. The Golgi p-73 and Beta-2 microglobulin levels in the plasma were determined using the ELISA method. Beta-2 microglobulin level was highest in the patients group and the difference was statistically significant. No significant difference was observed between the carriers group and the group of healthy controls. The Golgi P-73 values were significantly higher in the patients group in comparison to both other groups. However, the mean Golgi p-73 value was also significantly higher in the carrier group compared to the control group. In patients who are followed up with the diagnosis of chronic hepatitis B and who have undergone biopsies as candidates for treatment, the Beta-2 microglobulin and Golgi p-73 values may be important markers since they indicate the extent of the liver damage.

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“…Hallgren (1979) proposed that serum levels of β-2m in inflammatory diseases are closely correlated with lymphocyte infiltration, and increased levels have been shown in chronic hepatitis and acute viral hepatitis, both of which are characterized by lymphocyte infiltration in the liver. A number of studies have suggested that β-2m may be a useful marker in the development of hepatitis (Rashid et al 1981;Nagafuchi and Scheuer 1986;Yegane et al 2004). The measurement of β-2m levels in a number of hepatic diseases revealed that significantly elevated levels are found in the serum of patients with alcoholic and biliary cirrhosis, chronic hepatitis C, and metastatic liver cancer (Rashid et al 1981;Malaguarnera et al 1997).…”

Section: Discussionmentioning

confidence: 99%

Proteomic investigation of urinary markers of carbon-tetrachloride-induced hepatic fibrosis in the Hanover Wistar rat

et al. 2008

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Proteomic techniques such as two-dimensional gel electrophoresis (2-DGE) and mass spectrometry have become important tools for the identification of novel biomarkers of toxicity and disease. Ideally, such biomarkers need to be sensitive and organ specific, but, recently, it has become apparent that it would be an additional benefit to be able to measure biomarkers in samples obtained using non-invasive methods. The present study is concerned with the identification of novel urinary markers of hepatic fibrosis. In a carbon-tetrachloride-induced liver fibrosis rat model, analysis of urine by 2-DGE revealed an increase in the concentration of a number of proteins in animals with hepatic fibrosis. Using in-gel trypsin digest and nano-scale liquid chromatography combined with electrospray ionisation tandem mass spectrometry, protein spots were identified as copper/zinc superoxide dismutase, D: -dopachrome tautomerase, beta-2-microglobulin and neutrophil gelatinase associated lipocalin. These proteins are known to have important roles in the inflammatory response.

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The Role of .BETA.2 Microglobulin Levels in Monitoring Chronic Hepatitis B

Cited by 9 publications

References 13 publications

Elevated serum β2-microglobulin in individuals coinfected with hepatitis B and hepatitis D virus in a rural settings in Southwest Nigeria

Elevated serum β2-microglobulin in individuals coinfected with hepatitis B and hepatitis D virus in a rural settings in Southwest Nigeria

Prognostic value of Golgi P 73 and Beta 2-microglobulin in patients with Viral Hepatitis B

Proteomic investigation of urinary markers of carbon-tetrachloride-induced hepatic fibrosis in the Hanover Wistar rat

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