The Role of Beta Receptors in the Peripheral Vasculature of Calves with a Total Artificial Heart

Lk, Kalanges; Kd, Murray; Pf, Binkley; Pd, Myerowitz

doi:10.1097/00002216-198907000-00033

ASAIO Transactions

1989

DOI: 10.1097/00002216-198907000-00033

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The Role of Beta Receptors in the Peripheral Vasculature of Calves with a Total Artificial Heart

Kalanges Lk

Murray Kd²,

Binkley Pf³

et al.

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1991

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Calves Chronically Implanted with a Total Artificial Heart as a Pharmacological Model

et al. 1991

Int J Artif Organs

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Pharmacological therapy for congestive heart failure includes drugs that have both inotropic and vasoactive effects, although it is sometimes difficult to differentiate between the two effects. An animal with an implanted total artificial heart (TAH) allows the investigation of the vascular effect of these drugs in the absence of the effect on the myocardium. An advantage of the TAH model is its sensitivity to changes in right and left ventricular preload and afterload. Four instrumented TAH calves were given vasoactive drugs and the response was compared to control. Epinephrine, dopamine, isoproterenol, and nitroprusside were selected because of the predictability of their responses. Epinephrine caused a significant increase in systemic vascular resistance (SVR), and dopamine caused a significant increase in Pulmonary vascular resistance (PVR) and Isoproterenol caused a significant decrease in PVR. TAH implanted calves can thus serve as a pharmacological model to study the vascular response, which may be useful in investigation of new agents with inotropic and vascular effects.

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Calves Chronically Implanted with a Total Artificial Heart as a Pharmacological Model

et al. 1991

Int J Artif Organs

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The Role of Beta Receptors in the Peripheral Vasculature of Calves with a Total Artificial Heart

Cited by 1 publication

References 0 publications

Calves Chronically Implanted with a Total Artificial Heart as a Pharmacological Model

Calves Chronically Implanted with a Total Artificial Heart as a Pharmacological Model

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