The role of biochemical risk factors in the etiology of AIS in children and adults

Kopyta, Ilona; Zimny, Mikołaj; Sarecka-Hujar, Beata

doi:10.3109/00207454.2014.991925

Cited by 3 publications

(3 citation statements)

References 88 publications

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“…A total of 241 abstracts were retrieved initially. After exclusion of 219 irrelevant or duplicated reports, 22 potentially eligible studies were assessed by reviewing the full text 15 – 18 , 38 – 55 . In all, 15 studies were further excluded, including 4 studies with irrelevant outcomes, 3 studies containing ischemic stroke patients, 6 studies in which there was a lack of usable data and 2 prospective studies.…”

Section: Resultsmentioning

confidence: 99%

Plasma homocysteine concentrations and risk of intracerebral hemorrhage: a systematic review and meta-analysis

Zhou

Liang

et al. 2018

Sci Rep

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Intracerebral hemorrhage (ICH) has the highest mortality rate in all strokes. However, controversy still exists concerning the association between plasma homocysteine (Hcy) and ICH. A systematic review and meta-analysis was conducted using Pubmed, Embase, and Web of Science up to April 18, 2017. Standard mean difference (SMD) for mean differences of plasma Hcy levels with 95% confidence intervals (CI) was calculated. Seven studies including 667 ICH patients and 1821 ischemic stroke patients were identified for meta-analysis. Our results showed that Hcy levels in ICH patients were significantly higher than those in healthy controls (SMD = 0.59, 95% CI = 0.51–0.68, P < 0.001); no statistic differences were found in the comparisons of Hcy levels between ICH and ischemic stroke (SMD = −0.03, 95% CI = −0.13–0.06, P > 0.05); further subgroup analysis of ethnicity (Asians: SMD = 0.57, 95% CI = 0.48–0.66, P < 0.001; Caucasians: SMD = 0.77, 95% CI = 0.51–1.02, P < 0.001) and sample size (small samples: SMD = 0.55, 95% CI = 0.30–0.80, P < 0.001; large samples size: SMD = 0.60, 95% CI = 0.51–0.69, P < 0.001) in relation to Hcy levels between ICH and healthy controls did not change these results. In conclusion, Hcy level may be an aggravating factor in atherosclerosis, which is positively associated with high risk of ICH. Race-specific differences between Asians and Caucasians have no impact on the risk of ICH.

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Section: Resultsmentioning

confidence: 99%

Plasma homocysteine concentrations and risk of intracerebral hemorrhage: a systematic review and meta-analysis

Zhou

Liang

et al. 2018

Sci Rep

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“…We also observed that the presence of any type of seizures after stroke (early or late) may depend Due to the heterogeneity of AIS, different sets of genetic and non-genetic risk factors may exist and be related to the etiology and neurological burden of the disease in different populations. Among these factors, thrombophilia, hyperhomocysteinemia, dyslipidemia or MTHFR, FII, or FV gene polymorphisms can be distinguished [12][13][14]. Previous multicenter genetic studies, of 80 children Hemiparesis, seizures and other movement disorders 2 (2.60) 0 (0.00) 0 (0.00) 0 (0.00) 2 (10.00)…”

Section: Discussionmentioning

confidence: 99%

Risk factors, types and outcomes of arterial ischemic stroke in Polish pediatric patients: a retrospective single-center study

2021

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Introduction: Various neurological complications may occur as a consequence of arterial ischemic stroke (AIS) and have an impact on daily activity of the patients, costs of their medical care and rehabilitation. The aim of this study was to analyze risk factors, stroke symptoms and post-stroke consequences in Polish pediatric patients depending on stroke subtype. Material and methods: We retrospectively reviewed 77 children under the age of 18 years following their first AIS. Patients were white, Polish Caucasians, recruited in the Department of Pediatric Neurology at the Medical University of Silesia in Katowice (Poland). Statistical analysis was performed using Statistica 12.0. Results: Gender differed significantly between stroke subgroups (p = 0.030). The presence of focal cerebral arteriopathy (FCA) and chronic diseases was associated with type of AIS (p = 0.003 and p = 0.050, respectively). An outcome without neurological deterioration (normal outcome) was observed in 43% of children with lacunar anterior circulation infarct (LACI). Hemiparesis was present in almost all children with total anterior circulation infarct (TACI), in two thirds of children with partial anterior circulation infarct (PACI) and in almost 50% of children with LACI or posterior circulation infarct (POCI). In every child with hemiplegia the stroke symptom evolved into hemiparesis at follow-up. Additionally, patients with a normal outcome were older at the time of AIS than those with at least one neurological consequence (OR = 0.894, p = 0.034). Conclusions: The presence and number of neurological outcomes depend on stroke subtypes. A relation between the presence of post-stroke deficits and age at onset was observed. The odds of deficit after ischemic stroke decreases by an average of 10.6% if the child is 1 year older at the time of AIS.

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“…Stroke, a sudden loss of brain functions due to disturbance in the cerebral blood supply with symptoms lasting at least 24 h or leading to death, is the second leading cause of death worldwide (Lee et al 2014a;Kopyta et al 2015). It is also defined as a loss of neurological function of vascular origin, in which signs and symptoms may occcur suddenly (within seconds) or rapidly (within hours) (Guo et al 2013).…”

Section: Introductionmentioning

confidence: 99%

Astrocytic Response in the Striatum and Corpus Callosum of the Brain of Adult Wistar Rats with Global Ischaemia

Shokunbi¹,

Olopade²,

Femi-Akinlosotu³

et al. 2022

Nig J Neurosci

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Ischaemic stroke occurs when the blood supply to a part of the brain is suddenly interrupted. Astrocytes are known to maintain ionic homeostasis, scavenge free radicals and support neurogenesis. This study examined the astrocytic responses in the corpus callosum and striatum to global ischaemia with functional deficits in adult male rats. The common carotid artery (CCA) in adult rats was occluded temporarily (30 min) or permanently and then kept for 24 h or three days, while a sham operation was done for the control (n=10 per group). Neurobehavioural testing for motor deficits (square grid and pole tests) were carried out before sacrifice. The rats’ brains were stained with haematoxylin and eosin, and immunohistochemically with anti-glial fibrillary acidic protein for astrocytes. Quantitative data from behavioural tests were compared using analysis of variance, and significance was set at 0.05. The rats with permanent CCA occlusion had increased latency to turn and return to the base in the pole test, and reduced latency to fall in the square grid test compared to the temporary occlusion and control groups. Sections of the corpus callosum and striatum had increased proliferation and hypertrophy of the astrocytes in the permanent CCA occlusion, which was less obvious in the temporary occlusion group compared to the control. Global ischaemia caused neuronal degeneration and reactive astrogliosis in the corpus callosum and striatum, which were more pronounced in the group with permanent arterial occlusion than those that underwent reperfusion. Early reperfusion is crucial for structural and functional recovery following brain ischaemia in stroke management, and astrocytes play important roles in both the pathogenesis and recovery process.

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The role of biochemical risk factors in the etiology of AIS in children and adults

Cited by 3 publications

References 88 publications

Plasma homocysteine concentrations and risk of intracerebral hemorrhage: a systematic review and meta-analysis

Plasma homocysteine concentrations and risk of intracerebral hemorrhage: a systematic review and meta-analysis

Risk factors, types and outcomes of arterial ischemic stroke in Polish pediatric patients: a retrospective single-center study

Astrocytic Response in the Striatum and Corpus Callosum of the Brain of Adult Wistar Rats with Global Ischaemia

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