2021
DOI: 10.1097/mao.0000000000003259
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The Role of Biofilms in Chronic Otitis Media-Active Squamosal Disease: An Evaluative Study

Abstract: Objectives:To study the presence of biofilms in patients of chronic otitis media (COM)-active squamosal disease and to evaluate the microflora and clinical impact of biofilms.Methods:A total of 35 patients suffering from COM – active squamosal disease was studied. Cholesteatoma sample was collected at the time of mastoid surgery and the same was used to image for biofilms by scanning electron microscope. The said sample was also analyzed microbiologically.Results:Biofilms were present in 25 (72%) patients incl… Show more

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Cited by 5 publications
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“…The biofilm structure allows bacteria to tolerate adverse environmental conditions, develop resistance to antimicrobial agents and the host immune system, and provides an optimal environment for the exchange of extracellular DNA [1][2][3]. Bacterial biofilms play an important role in the pathogenesis and persistence of many chronic and recurrent upper respiratory tract infections, including chronic rhinosinusitis, adenoiditis, and otitis media [4][5][6]. These conditions are the most common reason for the use of antimicrobials in children and adults worldwide and significantly affect the daily functioning and quality of life of the affected individuals [7].…”
Section: Introductionmentioning
confidence: 99%
“…The biofilm structure allows bacteria to tolerate adverse environmental conditions, develop resistance to antimicrobial agents and the host immune system, and provides an optimal environment for the exchange of extracellular DNA [1][2][3]. Bacterial biofilms play an important role in the pathogenesis and persistence of many chronic and recurrent upper respiratory tract infections, including chronic rhinosinusitis, adenoiditis, and otitis media [4][5][6]. These conditions are the most common reason for the use of antimicrobials in children and adults worldwide and significantly affect the daily functioning and quality of life of the affected individuals [7].…”
Section: Introductionmentioning
confidence: 99%